Synthesis and biological evaluation of pyrido[2,3-d]pyrimidine-2,4-dione derivatives as eEF-2K inhibitors.
about
Eukaryotic elongation factor 2 kinase as a drug target in cancer, and in cardiovascular and neurodegenerative diseasesStructure of the C-Terminal Helical Repeat Domain of Eukaryotic Elongation Factor 2 KinaseA high-throughput screening assay for eukaryotic elongation factor 2 kinase inhibitors.Using docking and alchemical free energy approach to determine the binding mechanism of eEF2K inhibitors and prioritizing the compound synthesis.Eukaryotic elongation factor 2 kinase mediates monocrotaline-induced pulmonary arterial hypertension via reactive oxygen species-dependent vascular remodeling.
P2860
Synthesis and biological evaluation of pyrido[2,3-d]pyrimidine-2,4-dione derivatives as eEF-2K inhibitors.
description
2014 nî lūn-bûn
@nan
2014 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Synthesis and biological evalu ...... ivatives as eEF-2K inhibitors.
@ast
Synthesis and biological evalu ...... ivatives as eEF-2K inhibitors.
@en
type
label
Synthesis and biological evalu ...... ivatives as eEF-2K inhibitors.
@ast
Synthesis and biological evalu ...... ivatives as eEF-2K inhibitors.
@en
prefLabel
Synthesis and biological evalu ...... ivatives as eEF-2K inhibitors.
@ast
Synthesis and biological evalu ...... ivatives as eEF-2K inhibitors.
@en
P2093
P1476
Synthesis and biological evalu ...... rivatives as eEF-2K inhibitors
@en
P2093
Catrina A Chitjian
Clint D J Tavares
Eric V Anslyn
James L Bachman
Qiantao Wang
Ramakrishna Edupuganti
P304
P356
10.1016/J.BMC.2014.06.050
P407
P577
2014-06-30T00:00:00Z