Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria. - Wikidata - wikimedia - TriplyDB

Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria.

Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria.

http://www.wikidata.org/entity/Q35215092

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Crystal structure of the FimD usher bound to its cognate FimC-FimH substrate Chaperone-usher pathways: diversity and pilus assembly mechanism The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation Adhesive Pili in UTI Pathogenesis and Drug Development Virulence and Fitness Determinants of Uropathogenic Escherichia coli Exceptionally widespread nanomachines composed of type IV pilins: the prokaryotic Swiss Army knives Chemical inhibitors of the type three secretion system: disarming bacterial pathogens Urinary tract infections: epidemiology, mechanisms of infection and treatment options Antibiotic alternatives: the substitution of antibiotics in animal husbandry?Adhesive fiber stratification in uropathogenic Escherichia coli biofilms unveils oxygen-mediated control of type 1 pili Crystal structure of the ternary FimC-FimF(t)-FimD(N) complex indicates conserved pilus chaperone-subunit complex recognition by the usher FimD Design and Synthesis of C-2 Substituted Thiazolo and Dihydrothiazolo Ring-Fused 2-Pyridones: Pilicides with Increased Antivirulence Activity Structural and Functional Characterization of Pseudomonas aeruginosa CupB Chaperones Comparative Sequence, Structure and Redox Analyses of Klebsiella pneumoniae DsbA Show That Anti-Virulence Target DsbA Enzymes Fall into Distinct Classes Nitazoxanide Inhibits Pilus Biogenesis by Interfering with Folding of the Usher Protein in the Outer Membrane A 2-pyridone-amide inhibitor targets the glucose metabolism pathway of Chlamydia trachomatis.Nitazoxanide inhibits biofilm production and hemagglutination by enteroaggregative Escherichia coli strains by blocking assembly of AafA fimbriae.Escherichia coli resistance to nonbiocidal antibiofilm polysaccharides is rare and mediated by multiple mutations leading to surface physicochemical modifications Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation.Novel strategies to combat bacterial virulence.Syntheses and biological evaluation of 2-amino-3-acyl-tetrahydrobenzothiophene derivatives; antibacterial agents with antivirulence activity QseC-mediated dephosphorylation of QseB is required for expression of genes associated with virulence in uropathogenic Escherichia coli.The influence of pH on the specific adhesion of P piliated Escherichia coli Recent advances in understanding enteric pathogenic Escherichia coli.Transposon mutagenesis identifies uropathogenic Escherichia coli biofilm factors.Pilicide ec240 disrupts virulence circuits in uropathogenic Escherichia coli.Chemical biology applied to the study of bacterial pathogens.N-substituted 2-aminoimidazole inhibitors of MRSA biofilm formation accessed through direct 1,3-bis(tert-butoxycarbonyl)guanidine cyclization.Pilicides inhibit the FGL chaperone/usher assisted biogenesis of the Dr fimbrial polyadhesin from uropathogenic Escherichia coli Structural biology of the chaperone-usher pathway of pilus biogenesis Targeting virulence not viability in the search for future antibacterials.Structure/function analysis of Neisseria meningitidis PilW, a conserved protein that plays multiple roles in type IV pilus biology Mechanisms of protein oligomerization: inhibitor of functional amyloids templates α-synuclein fibrillation.Structural Insight into Archaic and Alternative Chaperone-Usher Pathways Reveals a Novel Mechanism of Pilus Biogenesis.The Biology of the Escherichia coli Extracellular Matrix Peptidomimetic Small Molecules Disrupt Type IV Secretion System Activity in Diverse Bacterial Pathogens.Lead optimization studies on FimH antagonists: discovery of potent and orally bioavailable ortho-substituted biphenyl mannosides Combinatorial small-molecule therapy prevents uropathogenic Escherichia coli catheter-associated urinary tract infections in mice.Distinguishing the contribution of type 1 pili from that of other QseB-misregulated factors when QseC is absent during urinary tract infection.Structure, Function, and Assembly of Adhesive Organelles by Uropathogenic Bacteria

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P2860

Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria.

http://www.wikidata.org/entity/Q35215092

description

2006 nî lūn-bûn

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2006 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2006 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria.

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Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria.

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type

label

Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria.

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Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria.

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prefLabel

Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria.

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Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria.

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Proceedings of the National Academy of Sciences of the United States of America

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Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria

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Andreas Larsson

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Eric Miller

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Floris Buelens

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Gabriel Waksman

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Han Remaut

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Jerome S Pinkner

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Mattias Hedenström

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Patrick Seed

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Veronica Aberg

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P2860

Structural basis of chaperone-subunit complex recognition by the type 1 pilus assembly platform FimD.

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

Structural basis of chaperone function and pilus biogenesis

X-ray structure of the FimC-FimH chaperone-adhesin complex from uropathogenic Escherichia coli

Structural basis of the interaction of the pyelonephritic E. coli adhesin to its human kidney receptor

Chaperone priming of pilus subunits facilitates a topological transition that drives fiber formation

Structure and biogenesis of the capsular F1 antigen from Yersinia pestis: preserved folding energy drives fiber formation

Crystal structure of chaperone protein PapD reveals an immunoglobulin fold

Raster3D Version 2.0. A program for photorealistic molecular graphics

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103

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6698394

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