Large collective motions regulate the functional properties of glutamate transporter trimers.
about
Visualizing functional motions of membrane transporters with molecular dynamics simulationsMechanisms of glutamate transportMolecular dynamics simulations of the mammalian glutamate transporter EAAT3Exploring the conformational transitions of biomolecular systems using a simple two-state anisotropic network modelSubstrate transport and anion permeation proceed through distinct pathways in glutamate transporters.Blocking dynamics of the SMR transporter EmrE impairs efflux activityMicroseconds simulations reveal a new sodium-binding site and the mechanism of sodium-coupled substrate uptake by LeuTDifferential regulation of two isoforms of the glial glutamate transporter EAAT2 by DLG1 and CaMKIIConstraints imposed by the membrane selectively guide the alternating access dynamics of the glutamate transporter GltPh.Structural intermediates in a model of the substrate translocation path of the bacterial glutamate transporter homologue GltPh.Charge compensation mechanism of a Na+-coupled, secondary active glutamate transporter.A Mutation in Transmembrane Domain 7 (TM7) of Excitatory Amino Acid Transporters Disrupts the Substrate-dependent Gating of the Intrinsic Anion Conductance and Drives the Channel into a Constitutively Open State.Computational Studies of Glutamate TransportersCysteine cross-linking defines the extracellular gate for the Leishmania donovani nucleoside transporter 1.1 (LdNT1.1).Conformational ensemble of the sodium-coupled aspartate transporter.Revealing an outward-facing open conformational state in a CLC Cl(-)/H(+) exchange transporterIntracellular gating in an inward-facing state of aspartate transporter Glt(Ph) is regulated by the movements of the helical hairpin HP2Biomolecular dynamics: order-disorder transitions and energy landscapesInduced fit substrate binding to an archeal glutamate transporter homologueIdentification of Hot Spots in Protein Structures Using Gaussian Network Model and Gaussian Naive Bayes.SLC1 glutamate transportersSingle molecule analysis reveals coexistence of stable serotonin transporter monomers and oligomers in the live cell plasma membrane.Sequence-based Gaussian network model for protein dynamics.Structure-Encoded Global Motions and Their Role in Mediating Protein-Substrate Interactions.De novo active sites for resurrected Precambrian enzymes.Gaussian network model can be enhanced by combining solvent accessibility in proteins.Neutralizing aspartate 83 modifies substrate translocation of excitatory amino acid transporter 3 (EAAT3) glutamate transporters.Global motions exhibited by proteins in micro- to milliseconds simulations concur with anisotropic network model predictions.Allosteric modulation of human dopamine transporter activity under conditions promoting its dimerization.Dynamical differences of hemoglobin and the ionotropic glutamate receptor in different states revealed by a new dynamics alignment method.Large-scale analysis of the dynamics of enzymes.Dynamics alignment: comparison of protein dynamics in the SCOP database.Shared dynamics of LeuT superfamily members and allosteric differentiation by structural irregularities and multimerization.
P2860
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P2860
Large collective motions regulate the functional properties of glutamate transporter trimers.
description
2011 nî lūn-bûn
@nan
2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Large collective motions regul ...... glutamate transporter trimers.
@ast
Large collective motions regul ...... glutamate transporter trimers.
@en
type
label
Large collective motions regul ...... glutamate transporter trimers.
@ast
Large collective motions regul ...... glutamate transporter trimers.
@en
prefLabel
Large collective motions regul ...... glutamate transporter trimers.
@ast
Large collective motions regul ...... glutamate transporter trimers.
@en
P2093
P2860
P356
P1476
Large collective motions regul ...... glutamate transporter trimers.
@en
P2093
Indira H Shrivastava
Spencer D Watts
Susan G Amara
P2860
P304
15141-15146
P356
10.1073/PNAS.1112216108
P407
P50
P577
2011-08-29T00:00:00Z