Synthesis and characterization of conformationally preorganized, (R)-diethylene glycol-containing γ-peptide nucleic acids with superior hybridization properties and water solubility
about
In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle deliveryCooperative hybridization of γPNA miniprobes to a repeating sequence motif and application to telomere analysis.γ Sulphate PNA (PNA S): highly selective DNA binding molecule showing promising antigene activity.Expanding the scope of PNA-encoded synthesis (PES): Mtt-protected PNA fully orthogonal to fmoc chemistry and a broad array of robust diversity-generating reactions.DNA sequencing and bar-coding using solid-state nanoporesEvaluating the effect of ionic strength on duplex stability for PNA having negatively or positively charged side chains.Single-stranded γPNAs for in vivo site-specific genome editing via Watson-Crick recognition.MicroRNA silencing for cancer therapy targeted to the tumour microenvironment.Purification and assembly of thermostable Cy5 labeled γ-PNAs into a 3D DNA nanocage.Polyanionic Carboxyethyl Peptide Nucleic Acids (ce-PNAs): Synthesis and DNA BindingTargeting DNA G-quadruplex structures with peptide nucleic acids.Electronic barcoding of a viral gene at the single-molecule levelNanoparticle for delivery of antisense γPNA oligomers targeting CCR5Focus on PNA Flexibility and RNA Binding using Molecular Dynamics and Metadynamics.miRNA therapeutics: delivery and biological activity of peptide nucleic acids targeting miRNAs.Multivalent LKγ-PNA oligomers bind to a human telomere DNA G-rich sequence to form quadruplexesβ,γ-Bis-substituted PNA with configurational and conformational switch: preferred binding to cDNA/RNA and cell-uptake studies.Purification and assembly of thermostable Cy5 labeled γ-PNAs into a 3D DNA nanocage.Sequence-unrestricted, Watson-Crick recognition of double helical B-DNA by (R)-miniPEG-γPNAs.Nanotechnology for delivery of peptide nucleic acids (PNAs)Versatility of peptide nucleic acids (PNAs): role in chemical biology, drug discovery, and origins of life.Probing of miniPEGγ-PNA-DNA Hybrid Duplex Stability with AFM Force SpectroscopySequence-specific RNA cleavage by PNA conjugates of the metal-free artificial ribonuclease tris(2-aminobenzimidazole).Peptide nucleic acids tagged with four lysine residues for amperometric genosensors.Recent advances in chemical modification of Peptide nucleic acids.Anti-tumor Activity of miniPEG-γ-Modified PNAs to Inhibit MicroRNA-210 for Cancer Therapy.Synthesis of PNA oligoether conjugates.Design of a "Mini" Nucleic Acid Probe for Cooperative Binding of an RNA-Repeated Transcript Associated with Myotonic Dystrophy Type 1.γPNA FRET Pair Miniprobes for Quantitative Fluorescent In Situ Hybridization to Telomeric DNA in Cells and Tissue.Highly sensitive and robust linear probe for detection of mRNA in cells.Design of Bivalent Nucleic Acid Ligands for Recognition of RNA-Repeated Expansion Associated with Huntington's Disease.Peptide Nucleic Acids as a Tool for Site-Specific Gene Editing.Therapeutic Peptide Nucleic Acids: Principles, Limitations, and Opportunities.De novo design of functional oligonucleotides with acyclic scaffolds.Fluorogenic PNA probes.In vivo demonstration of an active tumor pretargeting approach with peptide nucleic acid bioconjugates as complementary system.DNA- and RNA-binding ability of oligoDapT, a nucleobase-decorated peptide, for biomedical applications.In utero nanoparticle delivery for site-specific genome editing.
P2860
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P2860
Synthesis and characterization of conformationally preorganized, (R)-diethylene glycol-containing γ-peptide nucleic acids with superior hybridization properties and water solubility
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Synthesis and characterization ...... roperties and water solubility
@ast
Synthesis and characterization ...... roperties and water solubility
@en
type
label
Synthesis and characterization ...... roperties and water solubility
@ast
Synthesis and characterization ...... roperties and water solubility
@en
prefLabel
Synthesis and characterization ...... roperties and water solubility
@ast
Synthesis and characterization ...... roperties and water solubility
@en
P2093
P2860
P356
P1476
Synthesis and characterization ...... roperties and water solubility
@en
P2093
Bichismita Sahu
Bruce A Armitage
Danith H Ly
Iulia Sacui
Kimberly J Zanotti
Raman Bahal
Srinivas Rapireddy
P2860
P304
P356
10.1021/JO200482D
P407
P577
2011-06-15T00:00:00Z