Inhibition of MDM2 homodimerization by XIAP IRES stabilizes MDM2, influencing cancer cell survival. - Wikidata - wikimedia - TriplyDB

Inhibition of MDM2 homodimerization by XIAP IRES stabilizes MDM2, influencing cancer cell survival.

Inhibition of MDM2 homodimerization by XIAP IRES stabilizes MDM2, influencing cancer cell survival.

http://www.wikidata.org/entity/Q35232862

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Discovery of Dual Inhibitors of MDM2 and XIAP for Cancer Treatment.Glioblastomas with copy number gains in EGFR and RNF139 show increased expressions of carbonic anhydrase genes transformed by ENO1.Gossypol has anti-cancer effects by dual-targeting MDM2 and VEGF in human breast cancer.FKBP12 enhances sensitivity to chemotherapy-induced cancer cell apoptosis by inhibiting MDM2.Identification of XBP1-u as a novel regulator of the MDM2/p53 axis using an shRNA library.WSB1 overcomes oncogene-induced senescence by targeting ATM for degradation.Inhibition of IAP's and activation of p53 leads to caspase-dependent apoptosis in gastric cancer cells treated with Scutellarein.Inhibition of IAP’s and activation of p53 leads to caspase-dependent apoptosis in gastric cancer cells treated with Scutellarein.

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P2860

Inhibition of MDM2 homodimerization by XIAP IRES stabilizes MDM2, influencing cancer cell survival.

http://www.wikidata.org/entity/Q35232862

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2015 nî lūn-bûn

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2015 թուականի Մարտին հրատարակուած գիտական յօդուած

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2015 թվականի մարտին հրատարակված գիտական հոդված

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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name

Inhibition of MDM2 homodimeriz ...... luencing cancer cell survival.

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Inhibition of MDM2 homodimeriz ...... luencing cancer cell survival.

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type

label

Inhibition of MDM2 homodimeriz ...... luencing cancer cell survival.

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Inhibition of MDM2 homodimeriz ...... luencing cancer cell survival.

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prefLabel

Inhibition of MDM2 homodimeriz ...... luencing cancer cell survival.

@ast

Inhibition of MDM2 homodimeriz ...... luencing cancer cell survival.

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Molecular Cancer

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Inhibition of MDM2 homodimeriz ...... luencing cancer cell survival.

@en

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Hailong Zhang

http://www.w3.org/2001/XMLSchema#string

Jing Xiong

http://www.w3.org/2001/XMLSchema#string

Lubing Gu

http://www.w3.org/2001/XMLSchema#string

Muxiang Zhou

http://www.w3.org/2001/XMLSchema#string

Sha Yi

http://www.w3.org/2001/XMLSchema#string

Tao Liu

http://www.w3.org/2001/XMLSchema#string

P2860

Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

Critical role for Daxx in regulating Mdm2

Regulation of XIAP translation and induction by MDM2 following irradiation

Mdm2 promotes the rapid degradation of p53

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans

Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

mdm2 expression is induced by wild type p53 activity

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