Small Molecule End Group of Linear Polymer Determines Cell-type Gene Delivery Efficacy
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The relationship between terminal functionalization and molecular weight of a gene delivery polymer and transfection efficacy in mammary epithelial 2-D cultures and 3-D organotypic culturesUptake and transfection with polymeric nanoparticles are dependent on polymer end-group structure, but largely independent of nanoparticle physical and chemical properties.A novel assay for quantifying the number of plasmids encapsulated by polymer nanoparticles.Differential polymer structure tunes mechanism of cellular uptake and transfection routes of poly(β-amino ester) polyplexes in human breast cancer cellsPoly(β-amino ester)-DNA complexes: time-resolved fluorescence and cellular transfection studiesMutant MCP-1 protein delivery from layer-by-layer coatings on orthopedic implants to modulate inflammatory response.Discovery of cationic polymers for non-viral gene delivery using combinatorial approaches.Effects of base polymer hydrophobicity and end-group modification on polymeric gene deliveryNiemann-Pick C1 affects the gene delivery efficacy of degradable polymeric nanoparticles.Gene delivery nanoparticles specific for human microvasculature and macrovasculature.2011 Rita Schaffer lecture: nanoparticles for intracellular nucleic acid delivery.Poly(β-amino ester)-nanoparticle mediated transfection of retinal pigment epithelial cells in vitro and in vivo.Development of poly(β-amino ester)-based biodegradable nanoparticles for nonviral delivery of minicircle DNA.Non-viral gene delivery nanoparticles based on poly(β-amino esters) for treatment of glioblastoma.Polymeric nanoparticles for nonviral gene therapy extend brain tumor survival in vivo.Synthetic poly(ester amine) and poly(amido amine) nanoparticles for efficient DNA and siRNA delivery to human endothelial cellsTransfecting the hard-to-transfect lymphoma/leukemia cells using a simple cationic polymer nanocomplex.Effect of molecular weight of amine end-modified poly(β-amino ester)s on gene delivery efficiency and toxicityCystamine-terminated poly(beta-amino ester)s for siRNA delivery to human mesenchymal stem cells and enhancement of osteogenic differentiation.Nanoparticle-mediated transcriptional modification enhances neuronal differentiation of human neural stem cells following transplantation in rat brain.Poly(β-amino ester) nanoparticle delivery of TP53 has activity against small cell lung cancer in vitro and in vivo.Nanoparticle-mediated conversion of primary human astrocytes into neurons and oligodendrocytesThe transition from linear to highly branched poly(β-amino ester)s: Branching matters for gene delivery.(3-aminopropyl)-4-methylpiperazine end-capped poly(1,4-butanediol diacrylate-co-4-amino-1-butanol)-based multilayer films for gene delivery.The effect and role of carbon atoms in poly(β-amino ester)s for DNA binding and gene delivery.Student award winner in the Ph.D. category for the 2013 society for biomaterials annual meeting and exposition, april 10-13, 2013, Boston, Massachusetts : biomaterial-mediated cancer-specific DNA delivery to liver cell cultures using synthetic poly(Programming stem cells for therapeutic angiogenesis using biodegradable polymeric nanoparticles.Drug delivery strategies for therapeutic angiogenesis and antiangiogenesis.Advances in polymeric and inorganic vectors for nonviral nucleic acid delivery.Smart chemistry in polymeric nanomedicine.Nanotherapeutic systems for local treatment of brain tumors.Non-virally engineered human adipose mesenchymal stem cells produce BMP4, target brain tumors, and extend survivalEvaluation of polymeric gene delivery nanoparticles by nanoparticle tracking analysis and high-throughput flow cytometry.A Triple-Fluorophore-Labeled Nucleic Acid pH Nanosensor to Investigate Non-viral Gene Delivery.Enhancing oligodendrocyte differentiation by transient transcription activation via DNA nanoparticle-mediated transfection.Scaffold-mediated BMP-2 minicircle DNA delivery accelerated bone repair in a mouse critical-size calvarial defect model.Non-viral gene delivery via membrane-penetrating, mannose-targeting supramolecular self-assembled nanocomplexes.Degradable terpolymers with alkyl side chains demonstrate enhanced gene delivery potency and nanoparticle stability.Biodegradable STING agonist nanoparticles for enhanced cancer immunotherapy.Polymeric nanoparticle-based delivery of TRAIL DNA for cancer-specific killing.
P2860
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P2860
Small Molecule End Group of Linear Polymer Determines Cell-type Gene Delivery Efficacy
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Small Molecule End Group of Linear Polymer Determines Cell-type Gene Delivery Efficacy
@ast
Small Molecule End Group of Linear Polymer Determines Cell-type Gene Delivery Efficacy
@en
type
label
Small Molecule End Group of Linear Polymer Determines Cell-type Gene Delivery Efficacy
@ast
Small Molecule End Group of Linear Polymer Determines Cell-type Gene Delivery Efficacy
@en
prefLabel
Small Molecule End Group of Linear Polymer Determines Cell-type Gene Delivery Efficacy
@ast
Small Molecule End Group of Linear Polymer Determines Cell-type Gene Delivery Efficacy
@en
P2093
P2860
P50
P356
P1433
P1476
Small Molecule End Group of Linear Polymer Determines Cell-type Gene Delivery Efficacy
@en
P2093
Ahmed A Eltoukhy
Daniel G Anderson
David N Nguyen
Kerry P Mahon
P2860
P304
P356
10.1002/ADMA.200901718
P407
P577
2009-12-01T00:00:00Z