Copper-free Sonogashira cross-coupling for functionalization of alkyne-encoded proteins in aqueous medium and in bacterial cells
about
Click chemistry in complex mixtures: bioorthogonal bioconjugationPyrrolysyl-tRNA synthetase: an ordinary enzyme but an outstanding genetic code expansion toolBioorthogonal chemistry: strategies and recent developmentsExtracellular palladium-catalysed dealkylation of 5-fluoro-1-propargyl-uracil as a bioorthogonally activated prodrug approach.Development and bioorthogonal activation of palladium-labile prodrugs of gemcitabine.Palladium-mediated dealkylation of N-propargyl-floxuridine as a bioorthogonal oxygen-independent prodrug strategyMetal-catalyzed uncaging of DNA-binding agents in living cells†Electronic supplementary information (ESI) available: Synthesis and characterization of the studied molecules and required precursors. NMR, UV, and fluorescence spectra, titrations, cont4R- and 4S-iodophenyl hydroxyproline, 4R-pentynoyl hydroxyproline, and S-propargyl-4-thiolphenylalanine: conformationally biased and tunable amino acids for bioorthogonal reactions.Nano-palladium is a cellular catalyst for in vivo chemistryStorable N-phenylcarbamate palladacycles for rapid functionalization of an alkyne-encoded proteinFast and sequence-specific palladium-mediated cross-coupling reaction identified from phage display.Protein-polymer conjugation via ligand affinity and photoactivation of glutathione S-transferaseA genetically encoded alkyne directs palladium-mediated protein labeling on live mammalian cell surfaceIntrinsic bioconjugation for site-specific protein PEGylation at N-terminal serine.Methods to Make Homogenous Antibody Drug Conjugates.Genetic incorporation of twelve meta-substituted phenylalanine derivatives using a single pyrrolysyl-tRNA synthetase mutantStorable palladacycles for selective functionalization of alkyne-containing proteinsBiochemical analysis with the expanded genetic lexicon.Metal complex catalysis in living biological systems.Bioorthogonal labelling of biomolecules: new functional handles and ligation methods.Transition metal-mediated bioorthogonal protein chemistry in living cells.Selective chemical protein modification.Current approaches for RNA labeling in vitro and in cells based on click reactions.Development of bioorthogonal reactions and their applications in bioconjugation.Fluorometric imaging methods for palladium and platinum and the use of palladium for imaging biomolecules.Selective chemical labeling of proteins.In cellulo protein labelling with Ru-conjugate for luminescence imaging and bioorthogonal photocatalysis.Metal-catalyzed uncaging of DNA-binding agents in living cells.Living GenoChemetics by hyphenating synthetic biology and synthetic chemistry in vivoIncorporation of Methionine Analogues Into Bombyx mori Silk Fibroin for Click Modifications.Gold-catalyzed direct alkynylation of tryptophan in peptides using TIPS-EBX.Synthesis and Incorporation of Unnatural Amino Acids To Probe and Optimize Protein Bioconjugations.Quantum Chemical Calculations and Experimental Validation of the Photoclick Reaction for Fluorescent Labeling of the 5' cap of Eukaryotic mRNAs.N-alkynyl derivatives of 5-fluorouracil: susceptibility to palladium-mediated dealkylation and toxigenicity in cancer cell culture.Proline editing: a general and practical approach to the synthesis of functionally and structurally diverse peptides. Analysis of steric versus stereoelectronic effects of 4-substituted prolines on conformation within peptides.Enhanced aqueous Suzuki-Miyaura coupling allows site-specific polypeptide 18F-labeling.Mild bioconjugation through the oxidative coupling of ortho-aminophenols and anilines with ferricyanide.Site-selective azide incorporation into endogenous RNase A via a "chemistry" approach.Self-liganded Suzuki-Miyaura coupling for site-selective protein PEGylation.Intracellular activation of acetyl-CoA by an artificial reaction promoter and its fluorescent detection.
P2860
Q26828895-E18C841F-6E7A-4A5A-9D43-1EDC92F8A5E3Q26850882-5E50576F-3BA2-472A-A49E-97374929AC39Q27025530-1804B22D-C497-4F87-9D81-1E0F0B0148B3Q30572329-54E3B6A0-4C4C-4B74-B9CA-45EBA5790E10Q30582495-3FA514B6-8715-43B1-A9E2-7704492EE3BDQ30629552-89A77B3D-BFDB-4574-B26A-91412F1862ECQ30886571-ECBFF5C1-4E6C-415B-9A58-DA2CD60A7B9BQ31039611-19F7FC53-D317-4719-82AC-91D53E232E3BQ33903811-8EC99985-2D8D-49CF-A1A0-D471B27799C4Q34160917-2A70F8F8-B302-4E80-9776-6896D7B33672Q34211551-76A9A0E7-F356-42FB-9E43-4D3CBD0EA3A0Q34380245-4F495FAC-6565-464A-8143-353BA55B9503Q35121099-DEB0290D-71B3-40DC-BACF-79E799AE8CB4Q35170741-57832A00-730B-428D-9BE5-403D6A0EB9E1Q35523479-8AC7B86C-CE67-4FF0-8118-2F2FE8F2211FQ36614988-5B7B622E-A775-4CD5-B6C4-F87E89B7B054Q37354543-C516BEEA-0675-4AE7-B6F6-3A5BDF700CD3Q37982944-F2BF0316-7D92-4DB9-9593-16554D341E14Q38068312-2E835590-5F7F-4EA1-B7A0-2BE8403C64BAQ38130840-AAE76616-CC21-4C50-9222-245CA988E443Q38215435-ADE2A347-F36F-49A3-B22A-9A6D7CA87E34Q38246195-9DF0BA20-4F0A-402B-96D3-30F350FC72B0Q38249946-C69C4067-97BD-43F6-91FB-699D40D52754Q38358962-5FCDA2A5-6E82-497B-A39F-3AFCFB780275Q38364149-27338A79-1541-4A50-BB38-170FAEB47D50Q38759843-477F8171-52DA-46AC-9EA9-F8A2FBD1FE40Q38831089-E46339B2-EC8A-4E12-BBD8-844A007FC8D7Q40912813-1659F597-DDA5-4E67-B9BF-CAC1911A7EB2Q41331494-88ED4310-78D2-44DF-8147-BA474CD5CDF8Q41490728-F256EB2D-14FC-4BD7-AB07-4C2A33BE1EAAQ42172529-08CAB0BC-1EC8-44F5-8B68-1BC9EA149FBBQ42227270-4ADD4F4A-CD55-476A-838A-7BABF861BDE1Q42410685-9A910DC0-238E-4D1F-B989-0587C1B048B4Q42754840-47B88047-2B56-43C1-BA24-13172FA8730CQ42928366-B143C4FB-F76D-4CB4-8301-B35D54CC264AQ42931069-62DC6A06-3F87-40B0-8322-25E180203C1DQ44215549-C2BD8161-DCB0-4F25-8FA1-8E1DB4F6C192Q44451075-E61FF345-9F2E-4665-8469-6D9D848EBDBFQ45211170-2C4047F2-457B-436F-A7F0-938E3BF53A75Q45733814-EF21A7DD-2593-449D-A6F4-4D1B0BA82666
P2860
Copper-free Sonogashira cross-coupling for functionalization of alkyne-encoded proteins in aqueous medium and in bacterial cells
description
2011 nî lūn-bûn
@nan
2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Copper-free Sonogashira cross- ...... medium and in bacterial cells
@ast
Copper-free Sonogashira cross- ...... medium and in bacterial cells
@en
type
label
Copper-free Sonogashira cross- ...... medium and in bacterial cells
@ast
Copper-free Sonogashira cross- ...... medium and in bacterial cells
@en
prefLabel
Copper-free Sonogashira cross- ...... medium and in bacterial cells
@ast
Copper-free Sonogashira cross- ...... medium and in bacterial cells
@en
P2093
P2860
P356
P1476
Copper-free Sonogashira cross- ...... medium and in bacterial cells
@en
P2093
Reyna K V Lim
Selvakumar Edwardraja
P2860
P304
15316-15319
P356
10.1021/JA2066913
P407
P577
2011-09-13T00:00:00Z