P-REX1 creates a positive feedback loop to activate growth factor receptor, PI3K/AKT and MEK/ERK signaling in breast cancer.
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Therapeutic sensitivity to Rac GTPase inhibition requires consequential suppression of mTORC1, AKT, and MEK signaling in breast cancerP-Rex1 Expression in Invasive Breast Cancer in relation to Receptor Status and Distant Metastatic Site.Histidine-rich calcium binding protein promotes growth of hepatocellular carcinoma in vitro and in vivo.Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanomaStrategically Timing Inhibition of Phosphatidylinositol 3-Kinase to Maximize Therapeutic Index in Estrogen Receptor Alpha-Positive, PIK3CA-Mutant Breast Cancer.Simultaneous dual targeting of Par-4 and G6PD: a promising new approach in cancer therapy? Quintessence of a literature review on survival requirements of tumor cells.Activated Microglia Induce Bone Marrow Mesenchymal Stem Cells to Produce Glial Cell-Derived Neurotrophic Factor and Protect Neurons Against Oxygen-Glucose Deprivation Injury.Characterization of a P-Rex1 gene signature in breast cancer cellsERK/MAPK Signaling Drives Overexpression of the Rac-GEF, PREX1, in BRAF- and NRAS-Mutant Melanoma.Heregulin/ErbB3 Signaling Enhances CXCR4-Driven Rac1 Activation and Breast Cancer Cell Motility via Hypoxia-Inducible Factor 1α.Interaction of insulin-like growth factor-I and insulin resistance-related genetic variants with lifestyle factors on postmenopausal breast cancer risk.Gβγ Pathways in Cell Polarity and Migration Linked to Oncogenic GPCR Signaling: Potential Relevance in Tumor Microenvironment.Interplay between PREX2 mutations and the PI3K pathway and its effect on epigenetic regulation of gene expression in NRAS-mutant melanomaPtdIns(3,4,5)P3-dependent Rac Exchanger 1 (PREX1) Rac-Guanine Nucleotide Exchange Factor (GEF) Activity Promotes Breast Cancer Cell Proliferation and Tumor Growth via Activation of Extracellular Signal-regulated Kinase 1/2 (ERK1/2) Signaling.The Function of Embryonic Stem Cell-expressed RAS (E-RAS), a Unique RAS Family Member, Correlates with Its Additional Motifs and Its Structural Properties.Fasting glucose and body mass index as predictors of activity in breast cancer patients treated with everolimus-exemestane: The EverExt studyAn anti-cancer WxxxE-containing azurin polypeptide inhibits Rac1-dependent STAT3 and ERK/GSK-3β signaling in breast cancer cells.Multisite phosphorylation of P-Rex1 by protein kinase C.The PREX1/Rac signaling axis: Potential as a biomarker and therapeutic target in breast cancer.Protein biomarkers for subtyping breast cancer and implications for future research.Autophagy promotes escape from phosphatidylinositol 3-kinase inhibition in estrogen receptor-positive breast cancer.Estrogen receptor alpha drives mTORC1 inhibitor-induced feedback activation of PI3K/AKT in ER+ breast cancer.P-Rex1 is dispensable for Erk activation and mitogenesis in breast cancer.Zeb1 potentiates genome-wide gene transcription with Lef1 to promote glioblastoma cell invasion
P2860
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P2860
P-REX1 creates a positive feedback loop to activate growth factor receptor, PI3K/AKT and MEK/ERK signaling in breast cancer.
description
2014 nî lūn-bûn
@nan
2014 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年學術文章
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name
P-REX1 creates a positive feed ...... RK signaling in breast cancer.
@ast
P-REX1 creates a positive feed ...... RK signaling in breast cancer.
@en
type
label
P-REX1 creates a positive feed ...... RK signaling in breast cancer.
@ast
P-REX1 creates a positive feed ...... RK signaling in breast cancer.
@en
prefLabel
P-REX1 creates a positive feed ...... RK signaling in breast cancer.
@ast
P-REX1 creates a positive feed ...... RK signaling in breast cancer.
@en
P2093
P2860
P356
P1433
P1476
P-REX1 creates a positive feed ...... ERK signaling in breast cancer
@en
P2093
A M Gonzalez-Angulo
C L Arteaga
L K Symonds
L M Dillon
T W Miller
P2860
P2888
P304
P356
10.1038/ONC.2014.328
P407
P577
2014-10-06T00:00:00Z