ATP potentiates competitive inhibition of guanylyl cyclase A and B by the staurosporine analog, Gö6976: reciprocal regulation of ATP and GTP binding
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Catalytically Active Guanylyl Cyclase B Requires Endoplasmic Reticulum-mediated Glycosylation, and Mutations That Inhibit This Process Cause DwarfismA functional screen provides evidence for a conserved, regulatory, juxtamembrane phosphorylation site in guanylyl cyclase a and B.Dephosphorylation and inactivation of NPR2 guanylyl cyclase in granulosa cells contributes to the LH-induced decrease in cGMP that causes resumption of meiosis in rat oocytes.Heterozygous mutations in natriuretic peptide receptor-B (NPR2) gene as a cause of short stature.Guanylyl cyclases A and B are asymmetric dimers that are allosterically activated by ATP binding to the catalytic domain.A human skeletal overgrowth mutation increases maximal velocity and blocks desensitization of guanylyl cyclase-B.Luteinizing hormone reduces the activity of the NPR2 guanylyl cyclase in mouse ovarian follicles, contributing to the cyclic GMP decrease that promotes resumption of meiosis in oocytes.Dephosphorylation of juxtamembrane serines and threonines of the NPR2 guanylyl cyclase is required for rapid resumption of oocyte meiosis in response to luteinizing hormone.
P2860
Q28116378-00E4271D-C355-48A6-A920-8EA2DDE4D291Q34270975-2C4F8532-A334-4F97-BA9B-2A2E950F1BF8Q34341855-123E138D-840D-4E7C-B3C4-DC7D44C8921BQ35243490-370F6DDE-692F-4FA3-AF1E-C10FF2DF7769Q35543592-690274AF-2B52-457E-A5FD-D896FAFDDFE5Q35548309-AE6B0FED-68C3-4D49-9D00-E6887A2A2D9FQ35981008-18DA5A1F-80D8-4DDF-AE0B-BDA45B438C97Q36882363-EDF09F0F-F84C-4673-BAA1-0ADC92DFDC87
P2860
ATP potentiates competitive inhibition of guanylyl cyclase A and B by the staurosporine analog, Gö6976: reciprocal regulation of ATP and GTP binding
description
2011 nî lūn-bûn
@nan
2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
ATP potentiates competitive in ...... ulation of ATP and GTP binding
@ast
ATP potentiates competitive in ...... ulation of ATP and GTP binding
@en
type
label
ATP potentiates competitive in ...... ulation of ATP and GTP binding
@ast
ATP potentiates competitive in ...... ulation of ATP and GTP binding
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prefLabel
ATP potentiates competitive in ...... ulation of ATP and GTP binding
@ast
ATP potentiates competitive in ...... ulation of ATP and GTP binding
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P2860
P356
P1476
ATP potentiates competitive in ...... ulation of ATP and GTP binding
@en
P2093
Jerid W Robinson
Lincoln R Potter
P2860
P304
33841-33844
P356
10.1074/JBC.M111.273565
P407
P577
2011-08-02T00:00:00Z