PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation. - Wikidata - wikimedia - TriplyDB

PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation.

PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation.

http://www.wikidata.org/entity/Q35311785

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Clinical significance of T cell metabolic reprogramming in cancer Intrinsic and Tumor Microenvironment-Induced Metabolism Adaptations of T Cells and Impact on Their Differentiation and Function Metabolic communication in tumors: a new layer of immunoregulation for immune evasion T Cells and Cancer: How Metabolism Shapes Immunity Starved and Asphyxiated: How Can CD8(+) T Cells within a Tumor Microenvironment Prevent Tumor Progression The anticancer immune response of anti-PD-1/PD-L1 and the genetic determinants of response to anti-PD-1/PD-L1 antibodies in cancer patients T cell metabolism drives immunity New immunotherapies targeting the PD-1 pathway The PD1:PD-L1/2 Pathway from Discovery to Clinical Implementation Immunometabolism of regulatory T cells Feeding an army: The metabolism of T cells in activation, anergy, and exhaustion Dynamic Metabolism in Immune Response Anti-CD3 treatment up-regulates programmed cell death protein-1 expression on activated effector T cells and severely impairs their inflammatory capacity Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma.Autophagic Mechanism in Anti-Cancer Immunity: Its Pros and Cons for Cancer Therapy.Early changes in the metabolic profile of activated CD8(+) T cells.Transcriptional regulation of T cell metabolism.Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation.AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival.Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family.Uncoupling protein 2 regulates metabolic reprogramming and fate of antigen-stimulated CD8+ T cells.Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality.Impact of Metabolism on T-Cell Differentiation and Function and Cross Talk with Tumor Microenvironment.T cell metabolic reprogramming and plasticity.Nivolumab in combination with ipilimumab for the treatment of melanoma.Immunometabolism: Cellular Metabolism Turns Immune Regulator Suppression of Glut1 and Glucose Metabolism by Decreased Akt/mTORC1 Signaling Drives T Cell Impairment in B Cell Leukemia.Cytokines and metabolic factors regulate tumoricidal T-cell function during cancer immunotherapy.Immune checkpoints and their inhibition in cancer and infectious diseases.Metabolic regulation of immune responses: therapeutic opportunities.Metabolic programming in chronically stimulated T cells: Lessons from cancer and viral infections.A guide to immunometabolism for immunologists.T-cell metabolism governing activation, proliferation and differentiation; a modular view.Inhibitory Receptors Induced by VSV Viroimmunotherapy Are Not Necessarily Targets for Improving Treatment Efficacy.PD-1 blockade in Hodgkin's lymphoma: learning new tricks from an old teacher.Nutrients and the microenvironment to feed a T cell army.The safety of anti PD-1 therapeutics for the treatment of melanoma.Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway.The Therapeutic Potential of T Cell Metabolism.Metabolic reprogramming and apoptosis sensitivity: defining the contours of a T cell response.

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P2860

PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation.

http://www.wikidata.org/entity/Q35311785

description

2015 nî lūn-bûn

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2015 թուականի Մարտին հրատարակուած գիտական յօդուած

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2015 թվականի մարտին հրատարակված գիտական հոդված

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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name

PD-1 alters T-cell metabolic r ...... ysis and fatty acid oxidation.

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PD-1 alters T-cell metabolic r ...... ysis and fatty acid oxidation.

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type

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PD-1 alters T-cell metabolic r ...... ysis and fatty acid oxidation.

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PD-1 alters T-cell metabolic r ...... ysis and fatty acid oxidation.

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PD-1 alters T-cell metabolic r ...... ysis and fatty acid oxidation.

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PD-1 alters T-cell metabolic r ...... ysis and fatty acid oxidation.

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Nature Communications

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PD-1 alters T-cell metabolic r ...... ysis and fatty acid oxidation.

@en

P2093

Bianling Liu

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Duygu Sari

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Edward D Karoly

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Gordon J Freeman

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Kankana Bardhan

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Lauren N Bell

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Lequn Li

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Nikolaos Patsoukis

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Pankaj Seth

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Pranam Chatterjee

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P2860

Induction of glucose metabolism in stimulated T lymphocytes is regulated by mitogen-activated protein kinase signaling

Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities

T cell activation is driven by an ADP-dependent glucokinase linking enhanced glycolysis with mitochondrial reactive oxygen species generation

CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms

ATGL has a key role in lipid droplet/adiposome degradation in mammalian cells

Posttranscriptional control of T cell effector function by aerobic glycolysis

The PD-1 pathway in tolerance and autoimmunity

mTOR regulates memory CD8 T-cell differentiation

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

Spare respiratory capacity, oxidative stress and excitotoxicity

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6692

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10.1038/NCOMMS7692

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6

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2015-03-26T00:00:00Z

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274092433

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25809635

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4389235

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