The non-canonical protein binding site at the monomer-monomer interface of yeast proliferating cell nuclear antigen (PCNA) regulates the Rev1-PCNA interaction and Polζ/Rev1-dependent translesion DNA synthesis.
about
Eukaryotic DNA polymerase ζNMR Structure and Dynamics of the C-Terminal Domain from Human Rev1 and Its Complex with Rev1 Interacting Region of DNA Polymerase ηDef1 promotes the degradation of Pol3 for polymerase exchange to occur during DNA-damage--induced mutagenesis in Saccharomyces cerevisiae.The vital role of polymerase ζ and REV1 in mutagenic, but not correct, DNA synthesis across benzo[a]pyrene-dG and recruitment of polymerase ζ by REV1 to replication-stalled siteYeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrationsMutations at the Subunit Interface of Yeast Proliferating Cell Nuclear Antigen Reveal a Versatile Regulatory DomainPCNA trimer instability inhibits translesion synthesis by DNA polymerase η and by DNA polymerase δ.Interaction between the Rev1 C-Terminal Domain and the PolD3 Subunit of Polζ Suggests a Mechanism of Polymerase Exchange upon Rev1/Polζ-Dependent Translesion Synthesis.DNA-damage tolerance mediated by PCNA*Ub fusions in human cells is dependent on Rev1 but not Polη.DNA polymerases ζ and Rev1 mediate error-prone bypass of non-B DNA structures.Modulation of mutagenesis in eukaryotes by DNA replication fork dynamics and quality of nucleotide pools.Readers of PCNA modificationsTranslesion synthesis mechanisms depend on the nature of DNA damage in UV-irradiated human cells.Translesion Synthesis: Insights into the Selection and Switching of DNA Polymerases.Avoidance of APOBEC3B-induced mutation by error-free lesion bypassA small molecule inhibitor of monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin.Rev1 recruits ung to switch regions and enhances du glycosylation for immunoglobulin class switch DNA recombinationStructural basis for the molecular interactions in DNA damage tolerances.
P2860
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P2860
The non-canonical protein binding site at the monomer-monomer interface of yeast proliferating cell nuclear antigen (PCNA) regulates the Rev1-PCNA interaction and Polζ/Rev1-dependent translesion DNA synthesis.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
The non-canonical protein bind ...... ent translesion DNA synthesis.
@ast
The non-canonical protein bind ...... ent translesion DNA synthesis.
@en
type
label
The non-canonical protein bind ...... ent translesion DNA synthesis.
@ast
The non-canonical protein bind ...... ent translesion DNA synthesis.
@en
prefLabel
The non-canonical protein bind ...... ent translesion DNA synthesis.
@ast
The non-canonical protein bind ...... ent translesion DNA synthesis.
@en
P2093
P2860
P356
P1476
The non-canonical protein bind ...... ent translesion DNA synthesis.
@en
P2093
Neeru M Sharma
Olga V Kochenova
Polina V Shcherbakova
P2860
P304
33557-33566
P356
10.1074/JBC.M110.206680
P407
P577
2011-07-28T00:00:00Z