L-serine and glycine serve as major astroglia-derived trophic factors for cerebellar Purkinje neurons.
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Characterization of human phosphoserine aminotransferase involved in the phosphorylated pathway of L-serine biosynthesisCharacterization of M. tuberculosis SerB2, an essential HAD-family phosphatase, reveals novel propertiesCorticotropin-releasing factor and urocortin differentially modulate rat Purkinje cell dendritic outgrowth and differentiation in vitroCharacterization of rapid and high-affinity uptake of L-serine in neurons and astrocytes in primary cultureReactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway.Neu-Laxova syndrome, an inborn error of serine metabolism, is caused by mutations in PHGDH.V490M, a common mutation in 3-phosphoglycerate dehydrogenase deficiency, causes enzyme deficiency by decreasing the yield of mature enzyme.Cytodifferentiation of Bergmann glia and its relationship with Purkinje cells.Brain-specific Phgdh deletion reveals a pivotal role for L-serine biosynthesis in controlling the level of D-serine, an N-methyl-D-aspartate receptor co-agonist, in adult brain.Cellular origin and regulation of D- and L-serine in in vitro and in vivo models of cerebral ischemia.Intracerebral transplantation of mesenchymal stem cells into acid sphingomyelinase-deficient mice delays the onset of neurological abnormalities and extends their life span.L-serine in disease and developmentA 90-day Feeding Toxicity Study of l-Serine in Male and Female Fischer 344 Rats.Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regionsSubstrate Availability of Mutant SPT Alters Neuronal Branching and Growth Cone Dynamics in Dorsal Root GangliaEpileptogenesis in organotypic hippocampal cultures has limited dependence on culture medium composition.D-serine as a gliotransmitter and its roles in brain development and disease.High-resolution magic angle spinning magnetic resonance spectroscopy detects glycine as a biomarker in brain tumors.D-serine in glia and neurons derives from 3-phosphoglycerate dehydrogenase.Comparison of alterations in amino acids content in cultured astrocytes or neurons exposed to methylmercury separately or in co-cultureSuppressing N-Acetyl-l-Aspartate Synthesis Prevents Loss of Neurons in a Murine Model of Canavan LeukodystrophyGenetic and functional analyses demonstrate a role for abnormal glycinergic signaling in autism.GABA(A) receptor and glycine receptor activation by paracrine/autocrine release of endogenous agonists: more than a simple communication pathway.A world of sphingolipids and glycolipids in the brain--novel functions of simple lipids modified with glucose.On the phenotypic spectrum of serine biosynthesis defects.High-Resolution Magic Angle Spinning Nuclear Magnetic Resonance of Intact Zebrafish Embryos Detects Metabolic Changes Following Exposure to Teratogenic Polymethoxyalkenes from Algae.A novel role of L-serine (L-Ser) for the expression of nuclear factor of activated T cells (NFAT)2 in receptor activator of nuclear factor kappa B ligand (RANKL)-induced osteoclastogenesis in vitro.A homozygous mutation in SLC1A4 in siblings with severe intellectual disability and microcephaly.The glycerophospho metabolome and its influence on amino acid homeostasis revealed by brain metabolomics of GDE1(-/-) mice.Novel Report of Phosphoserine Phosphatase Deficiency in an Adult with Myeloneuropathy and Limb Contractures.Effects of FAK ablation on cerebellar foliation, Bergmann glia positioning and climbing fiber territory on Purkinje cells.A phenotypic small-molecule screen identifies an orphan ligand-receptor pair that regulates neural stem cell differentiationFosB null mutant mice show enhanced methamphetamine neurotoxicity: potential involvement of FosB in intracellular feedback signaling and astroglial function.Glycine receptors and glycinergic synaptic transmission in the deep cerebellar nuclei of the rat: a patch-clamp study.Kinetic properties of the alpha2 homo-oligomeric glycine receptor impairs a proper synaptic functioning.Targeted disruption of the mouse 3-phosphoglycerate dehydrogenase gene causes severe neurodevelopmental defects and results in embryonic lethality.Distinct cellular expressions of creatine synthetic enzyme GAMT and creatine kinases uCK-Mi and CK-B suggest a novel neuron-glial relationship for brain energy homeostasis.Cerebellar pathology in transgenic mice expressing the pseudorabies virus immediate-early protein IE180.ATM deficiency induces oxidative stress and endoplasmic reticulum stress in astrocytes.Dietary L-serine modifies free amino acid composition of maternal milk and lowers the body weight of the offspring in mice.
P2860
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P2860
L-serine and glycine serve as major astroglia-derived trophic factors for cerebellar Purkinje neurons.
description
2000 nî lūn-bûn
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2000 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
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2000 թվականի հոտեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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name
L-serine and glycine serve as ...... r cerebellar Purkinje neurons.
@ast
L-serine and glycine serve as ...... r cerebellar Purkinje neurons.
@en
type
label
L-serine and glycine serve as ...... r cerebellar Purkinje neurons.
@ast
L-serine and glycine serve as ...... r cerebellar Purkinje neurons.
@en
prefLabel
L-serine and glycine serve as ...... r cerebellar Purkinje neurons.
@ast
L-serine and glycine serve as ...... r cerebellar Purkinje neurons.
@en
P2093
P2860
P356
P1476
L-serine and glycine serve as ...... r cerebellar Purkinje neurons.
@en
P2093
M Watanabe
M Yamasaki
T Yamamoto
Y Hirabayashi
P2860
P304
11528-11533
P356
10.1073/PNAS.200364497
P407
P577
2000-10-01T00:00:00Z