A phase II study of 2-methoxyestradiol nanocrystal colloidal dispersion alone and in combination with sunitinib malate in patients with metastatic renal cell carcinoma progressing on sunitinib malate.
about
Induction of the intrinsic apoptotic pathway via a new antimitotic agent in an esophageal carcinoma cell lineInvestigational cancer drugs targeting cell metabolism in clinical development.Targeted NF1 cancer therapeutics with multiple modes of action: small molecule hormone-like agents resembling the natural anticancer metabolite, 2-methoxyoestradiol.DNA strand breaks induced by nuclear hijacking of neuronal NOS as an anti-cancer effect of 2-methoxyestradiolA bis-sulphamoylated estradiol derivative induces ROS-dependent cell cycle abnormalities and subsequent apoptosis.Inclusion complexes of 2-methoxyestradiol with dimethylated and permethylated β-cyclodextrins: models for cyclodextrin-steroid interaction.Inhibition of hypoxia inducible factor-1α attenuates abdominal aortic aneurysm progression through the down-regulation of matrix metalloproteinases.Applications of nanoparticles in the detection and treatment of kidney diseasesPTEN status mediates 2ME2 anti-tumor efficacy in preclinical glioblastoma models: role of HIF1α suppression.Nanoparticles containing insoluble drug for cancer therapy.Small-molecule inhibitors of the HIF pathway and synthetic lethal interactions.Hypoxia inducible factor pathway inhibitors as anticancer therapeutics.Benefit, Risk, and Outcomes in Drug Development: A Systematic Review of Sunitinib.Design, synthesis, and structure-activity relationships of pyrimido[4,5-b]indole-4-amines as microtubule depolymerizing agents that are effective against multidrug resistant cells.2-Methoxyestradiol enhances radiosensitivity in radioresistant melanoma MDA-MB-435R cells by regulating glycolysis via HIF-1α/PDK1 axis.Design, Synthesis, and Preclinical Evaluation of 4-Substituted-5-methyl-furo[2,3-d]pyrimidines as Microtubule Targeting Agents That Are Effective against Multidrug Resistant Cancer Cells.Neuronal Nitric Oxide Synthase-Mediated Genotoxicity of 2-Methoxyestradiol in Hippocampal HT22 Cell Line.2-methoxyestradiol impacts on amino acids-mediated metabolic reprogramming in osteosarcoma cells by its interaction with NMDA receptor.Neuronal nitric oxide synthase induction in the antitumorigenic and neurotoxic effects of 2-methoxyestradiol.Sunitinib in kidney cancer: 10 years of experience and development.2-Methoxyestradiol Affects Mitochondrial Biogenesis Pathway and Succinate Dehydrogenase Complex Flavoprotein Subunit A in Osteosarcoma Cancer Cells.The in vitro effects of a novel estradiol analog on cell proliferation and morphology in human epithelial cervical carcinoma.2ME2 increase radiation-induced apoptosis of keloid fibroblasts by targeting HIF-1α in vitro.2-Methoxyestradiol Attenuates Testosterone-Induced Benign Prostate Hyperplasia in Rats through Inhibition of HIF-1/TGF-/Smad2 Axis
P2860
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P2860
A phase II study of 2-methoxyestradiol nanocrystal colloidal dispersion alone and in combination with sunitinib malate in patients with metastatic renal cell carcinoma progressing on sunitinib malate.
description
2010 nî lūn-bûn
@nan
2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
A phase II study of 2-methoxye ...... ogressing on sunitinib malate.
@ast
A phase II study of 2-methoxye ...... ogressing on sunitinib malate.
@en
type
label
A phase II study of 2-methoxye ...... ogressing on sunitinib malate.
@ast
A phase II study of 2-methoxye ...... ogressing on sunitinib malate.
@en
prefLabel
A phase II study of 2-methoxye ...... ogressing on sunitinib malate.
@ast
A phase II study of 2-methoxye ...... ogressing on sunitinib malate.
@en
P2093
P2860
P1476
A phase II study of 2-methoxye ...... ogressing on sunitinib malate.
@en
P2093
Anthony Treston
Jamie Arnott
Jens Eickhoff
Justine Yang Bruce
Michael Carducci
Roberto Pili
Theodore Logan
P2860
P2888
P304
P356
10.1007/S10637-010-9618-9
P577
2010-12-22T00:00:00Z