Conversion of human interleukin-4 into a high affinity antagonist by a single amino acid replacement.
about
Immune response induction and new effector mechanisms possibly involved in protection conferred by the Cuban anti-meningococcal BC vaccineInsights into cytokine-receptor interactions from cytokine engineeringComparative model building of interleukin-7 using interleukin-4 as a template: a structural hypothesis that displays atypical surface chemistry in helix D important for receptor activation.A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor.D1 cap region involved in the receptor recognition and neural cell survival activity of human ciliary neurotrophic factorSimilarities and differences in signal transduction by interleukin 4 and interleukin 13: analysis of Janus kinase activationInter-species chimeras of leukaemia inhibitory factor define a major human receptor-binding determinantIL-27 structural analysis demonstrates similarities with ciliary neurotrophic factor (CNTF) and leads to the identification of antagonistic variantsA mixed-charge pair in human interleukin 4 dominates high-affinity interaction with the receptor alpha chainDual effect of interleukin 4 on HIV-1 expression: implications for viral phenotypic switch and disease progression.An immune cell-selective interleukin 4 agonist.Hematopoietic cytokines: similarities and differences in the structures, with implications for receptor binding.Direct evidence of a heterotrimeric complex of human interleukin-4 with its receptors.Targeting IL4/IL4R for the treatment of epithelial cancer metastasis.Understanding cytokine and growth factor receptor activation mechanisms.The RgpA-Kgp proteinase-adhesin complexes of Porphyromonas gingivalis Inactivate the Th2 cytokines interleukin-4 and interleukin-5Pinellia ternata, Citrus reticulata, and their combinational prescription inhibit eosinophil infiltration and airway hyperresponsiveness by suppressing CCR3+ and Th2 cytokines production in the ovalbumin-induced asthma model.Multifarious determinants of cytokine receptor signaling specificity.Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transductionRegulation of 15-lipoxygenase expression in lung epithelial cells by interleukin-4.Display of passenger proteins on the surface of Escherichia coli K-12 by the enterohemorrhagic E. coli intimin EaeA.Rational design of interleukin-21 antagonist through selective elimination of the gammaC binding epitope.Soluble receptors for cytokines and growth factors: generation and biological function.Two distinct functional sites of human interleukin 4 are identified by variants impaired in either receptor binding or receptor activation.Receptor binding properties of four-helix-bundle growth factors deduced from electrostatic analysis.An interleukin 4 (IL-4) mutant protein inhibits both IL-4 or IL-13-induced human immunoglobulin G4 (IgG4) and IgE synthesis and B cell proliferation: support for a common component shared by IL-4 and IL-13 receptors
P2860
Q24548670-94445244-6C62-43A9-8D19-E1899E4C0ABBQ26852703-81E62722-DF5C-4409-80F3-7802C071CDB8Q30878481-2CC3130E-2E43-4C50-A448-296FFA38E5B0Q33241201-A77E3A6B-91F0-4010-A60F-5416F8BEFFB8Q33910844-9FB597DB-5EA5-4A83-B288-46F1F68E0EBDQ33998449-14238A77-4506-45CF-A95A-FAFAEA5D2AD3Q34059125-695C0338-C017-4AC0-9C3D-44C209BF9784Q34320238-B1BFCAE5-6752-402B-85AC-610B2306BB81Q36019141-672B2DEE-2661-43C5-90B3-A8E91FCC38E8Q36225692-5578D545-42F3-4F10-9804-434F59359549Q36261184-AD85E103-6A27-4650-8E93-6A9FDDD8B324Q36278179-5898E2CE-374E-4F4E-82E4-E3A049FBA14FQ36279052-54722FAE-ECA3-4320-B969-656ED1502B0DQ36296416-58C1A270-C714-458D-8EFA-8F7BB5543F0EQ36509470-13E0DBA0-7270-439F-9DD3-FA4990E5FF21Q37145018-0653075F-B74C-445B-8BFB-585FBEA32567Q37286252-F0DCA7A7-43BC-4D34-ADD8-962D0EF84971Q38175584-0ADE1175-EE2E-4542-8D0A-BFC9E4BE5085Q38317997-E7CF4ED7-D385-492E-A963-F7A802D4638FQ38354053-404297D1-0464-43BE-B7E9-8A04B3B1D211Q39505640-DFE8E6BE-1B5B-44C1-80CC-385309B930E9Q39737725-FD224134-D064-4B09-8EC9-42053D72BD04Q40656511-5D584481-633A-4356-8593-BF963C5B7C83Q40874531-53A642C8-A02E-48CF-92BA-485CD24CF65BQ41830979-C7433857-A8A7-42E8-924A-6D1F1CA92FF3Q41917400-0BF8E5DA-A04E-4370-A800-27F99F2F5031
P2860
Conversion of human interleukin-4 into a high affinity antagonist by a single amino acid replacement.
description
1992 nî lūn-bûn
@nan
1992 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
name
Conversion of human interleuki ...... single amino acid replacement.
@ast
Conversion of human interleuki ...... single amino acid replacement.
@en
type
label
Conversion of human interleuki ...... single amino acid replacement.
@ast
Conversion of human interleuki ...... single amino acid replacement.
@en
prefLabel
Conversion of human interleuki ...... single amino acid replacement.
@ast
Conversion of human interleuki ...... single amino acid replacement.
@en
P2093
P2860
P1433
P1476
Conversion of human interleuki ...... single amino acid replacement.
@en
P2093
P2860
P304
P407
P577
1992-09-01T00:00:00Z