Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance by a novel mechanism involving the hijacking of lysosomal P-glycoprotein (Pgp).
about
Targeting cancer by binding iron: Dissecting cellular signaling pathwaysThe Metastasis Suppressor, N-MYC Downstream-regulated Gene-1 (NDRG1), Down-regulates the ErbB Family of Receptors to Inhibit Downstream Oncogenic Signaling PathwaysDifferential targeting of the cyclin-dependent kinase inhibitor, p21CIP1/WAF1, by chelators with anti-proliferative activity in a range of tumor cell-types.Glucose Modulation Induces Lysosome Formation and Increases Lysosomotropic Drug Sequestration via the P-Glycoprotein Drug Transporter.Novel and potent anti-tumor and anti-metastatic di-2-pyridylketone thiosemicarbazones demonstrate marked differences in pharmacology between the first and second generation lead agents.Targeting the Metastasis Suppressor, N-Myc Downstream Regulated Gene-1, with Novel Di-2-Pyridylketone Thiosemicarbazones: Suppression of Tumor Cell Migration and Cell-Collagen Adhesion by Inhibiting Focal Adhesion Kinase/Paxillin Signaling.Impact of Stepwise NH2-Methylation of Triapine on the Physicochemical Properties, Anticancer Activity, and Resistance CircumventionThe novel thiosemicarbazone, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), inhibits neuroblastoma growth in vitro and in vivo via multiple mechanisms.The iron chelator Dp44mT suppresses osteosarcoma's proliferation, invasion and migration: in vitro and in vivoA mechanism for overcoming P-glycoprotein-mediated drug resistance: novel combination therapy that releases stored doxorubicin from lysosomes via lysosomal permeabilization using Dp44mT or DpC.Downregulation of hepatic multi-drug resistance protein 1 (MDR1) after copper exposure.Inhibition of paclitaxel resistance and apoptosis induction by cucurbitacin B in ovarian carcinoma cells.Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT), an anticancer agent, exerts an anti-inflammatory effect in activated human mast cells.Copper and conquer: copper complexes of di-2-pyridylketone thiosemicarbazones as novel anti-cancer therapeutics.Iron Chelators and Exogenic Photosensitizers. Synergy through Oxidative Stress Gene Expression.Proteomic analysis of extracellular vesicles from medullospheres reveals a role for iron in the cancer progression of medulloblastoma.Copper that cancer with lysosomal love!Troxerutin with copper generates oxidative stress in cancer cells: Its possible chemotherapeutic mechanism against hepatocellular carcinoma.Disulfide-masked iron prochelators: Effects on cell death, proliferation, and hemoglobin production.Tumor stressors induce two mechanisms of intracellular p-glycoprotein-mediated resistance that are overcome by lysosomal-targeted thiosemicarbazones.The role of oxidative stress in activity of anticancer thiosemicarbazones.
P2860
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P2860
Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance by a novel mechanism involving the hijacking of lysosomal P-glycoprotein (Pgp).
description
2015 nî lūn-bûn
@nan
2015 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Di-2-pyridylketone 4,4-dimethy ...... ysosomal P-glycoprotein (Pgp).
@ast
Di-2-pyridylketone 4,4-dimethy ...... ysosomal P-glycoprotein (Pgp).
@en
type
label
Di-2-pyridylketone 4,4-dimethy ...... ysosomal P-glycoprotein (Pgp).
@ast
Di-2-pyridylketone 4,4-dimethy ...... ysosomal P-glycoprotein (Pgp).
@en
prefLabel
Di-2-pyridylketone 4,4-dimethy ...... ysosomal P-glycoprotein (Pgp).
@ast
Di-2-pyridylketone 4,4-dimethy ...... ysosomal P-glycoprotein (Pgp).
@en
P2093
P2860
P50
P356
P1476
Di-2-pyridylketone 4,4-dimethy ...... ysosomal P-glycoprotein (Pgp).
@en
P2093
Akanksha Arvind
Alexandra Stacy
Danae Sharp
Elaine Gutierrez
Patric J Jansson
Sanaz Maleki
Tetsuo Yamagishi
P2860
P304
P356
10.1074/JBC.M114.631283
P407
P577
2015-02-26T00:00:00Z