Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy
about
Nuclear receptors and AMPK: can exercise mimetics cure diabetes?Dysregulated metabolism contributes to oncogenesisMetformin as a new anti-cancer drug in adrenocortical carcinomaDiscovery of Novel Insulin Sensitizers: Promising Approaches and Targets.Selective inhibition of deactivated mitochondrial complex I by biguanidesThe double trouble of metabolic diseases: the diabetes-cancer link.Molecular features of biguanides required for targeting of mitochondrial respiratory complex I and activation of AMP-kinase.Germline BRCA1 mutation reprograms breast epithelial cell metabolism towards mitochondrial-dependent biosynthesis: evidence for metformin-based "starvation" strategies in BRCA1 carriers.New insight for metformin against bladder cancer.Metabolic Modification in Gastrointestinal Cancer Stem Cells: Characteristics and Therapeutic Approaches.Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin.The emerging role of metformin in gestational diabetes mellitus.Protective effect of metformin in an aberrant crypt foci model induced by 1,2-dimethylhydrazine: Modulation of oxidative stress and inflammatory process.Natural alkaloid bouchardatine ameliorates metabolic disorders in high-fat diet-fed mice by stimulating the sirtuin 1/liver kinase B-1/AMPK axis.Metformin Mediates Protection against Legionella Pneumonia through Activation of AMPK and Mitochondrial Reactive Oxygen Species.Targeting Metabolism for Cancer Therapy.Metformin Has Positive Therapeutic Effects in Colon Cancer and Lung Cancer.Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin.Targeting Oxygen-Sensing Prolyl Hydroxylase for Metformin-Associated Lactic Acidosis Treatment.Propofol induces a metabolic switch to glycolysis and cell death in a mitochondrial electron transport chain-dependent manner.p53 and metabolism: from mechanism to therapeutics.Deciphering the Dichotomous Effects of PGC-1α on Tumorigenesis and Metastasis.Metabolic Profiles Associated With Metformin Efficacy in Cancer
P2860
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P2860
Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy
description
2014 nî lūn-bûn
@nan
2014 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Understanding the complex-I-ty ...... tion to improve cancer therapy
@ast
Understanding the complex-I-ty ...... tion to improve cancer therapy
@en
type
label
Understanding the complex-I-ty ...... tion to improve cancer therapy
@ast
Understanding the complex-I-ty ...... tion to improve cancer therapy
@en
prefLabel
Understanding the complex-I-ty ...... tion to improve cancer therapy
@ast
Understanding the complex-I-ty ...... tion to improve cancer therapy
@en
P2860
P1433
P1476
Understanding the complex-I-ty ...... tion to improve cancer therapy
@en
P2093
Matthew G Vander Heiden
P2860
P2888
P356
10.1186/S12915-014-0082-4
P577
2014-10-24T00:00:00Z
P5875
P6179
1000162666