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Signaling pathways underlying the rapid antidepressant actions of ketamine

Signaling pathways underlying the rapid antidepressant actions of ketamine

http://www.wikidata.org/entity/Q35375293

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Antidepressant effects of ketamine: mechanisms underlying fast-acting novel antidepressants Neuroplasticity and the next wave of antidepressant strategies Comorbidity Factors and Brain Mechanisms Linking Chronic Stress and Systemic Illness Potential of Glutamate-Based Drug Discovery for Next Generation Antidepressants Antidepressant effects of the muscarinic cholinergic receptor antagonist scopolamine: a review Targeting the glutamatergic system to treat major depressive disorder: rationale and progress to date Conversion of psychological stress into cellular stress response: roles of the sigma-1 receptor in the process Consolidation and translation regulation GLYX-13, an NMDA receptor glycine site functional partial agonist enhances cognition and produces antidepressant effects without the psychotomimetic side effects of NMDA receptor antagonists Regulation of fear extinction versus other affective behaviors by discrete cortical scaffolding complexes associated with NR2B and PKA signaling The atypical antidepressant and neurorestorative agent tianeptine is a μ-opioid receptor agonist Long-lasting antidepressant action of ketamine, but not glycogen synthase kinase-3 inhibitor SB216763, in the chronic mild stress model of mice Rapid antidepressants stimulate the decoupling of GABA(B) receptors from GIRK/Kir3 channels through increased protein stability of 14-3-3η Conceptual convergence: increased inflammation is associated with increased basal ganglia glutamate in patients with major depression Schizophrenia and Depression Co-Morbidity: What We have Learned from Animal Models.Glutamate and its receptors in the pathophysiology and treatment of major depressive disorder Negative Allosteric Modulators Selective for The NR2B Subtype of The NMDA Receptor Impair Cognition in Multiple Domains Disinhibition of somatostatin-positive GABAergic interneurons results in an anxiolytic and antidepressant-like brain state.S-Ketamine Rapidly Reverses Synaptic and Vascular Deficits of Hippocampus in Genetic Animal Model of Depression.Effects of ketamine and propofol on motor evoked potentials elicited by intracranial microstimulation during deep brain stimulation Erzhi Pill® Repairs Experimental Liver Injury via TSC/mTOR Signaling Pathway Inhibiting Excessive Apoptosis.MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes.Antidepressant effects of ketamine and the roles of AMPA glutamate receptors and other mechanisms beyond NMDA receptor antagonism Glutamate receptor antagonists as fast-acting therapeutic alternatives for the treatment of depression: ketamine and other compounds.Antidepressant Effects of Ketamine on Depression-like Behavior in Juvenile Mice after Neonatal Dexamethasone Exposure.Antidepressant effects of TrkB ligands on depression-like behavior and dendritic changes in mice after inflammation.Ketamine and other N-methyl-D-aspartate receptor antagonists in the treatment of depression: a perspective review.Ketamine and phencyclidine: the good, the bad and the unexpected.New targets for rapid antidepressant action.HCN Channel Targets for Novel Antidepressant Treatment.Next-generation treatments for mental disorders.GluN2B-containing NMDA receptors regulate depression-like behavior and are critical for the rapid antidepressant actions of ketamine Antidepressant-like activity of magnesium in the olfactory bulbectomy model is associated with the AMPA/BDNF pathway.Antidepressant-like effects of erythropoietin: a focus on behavioural and hippocampal processes.Clinical predictors of ketamine response in treatment-resistant major depression.Profiling of Proteins Regulated by Venlafaxine during Neural Differentiation of Human Cells NMDA receptor antagonist ketamine impairs feature integration in visual perception Expression of the 5-HT1A serotonin receptor in the hippocampus is required for social stress resilience and the antidepressant-like effects induced by the nicotinic partial agonist cytisine Genetic ablation of the GluK4 kainate receptor subunit causes anxiolytic and antidepressant-like behavior in mice.Tramadol pretreatment enhances ketamine-induced antidepressant effects and increases mammalian target of rapamycin in rat hippocampus and prefrontal cortex.

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Signaling pathways underlying the rapid antidepressant actions of ketamine

http://www.wikidata.org/entity/Q35375293

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2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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J.NEUROPHARM.2011.08.044

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Neuropharmacology

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Signaling pathways underlying the rapid antidepressant actions of ketamine

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George Aghajanian

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Nanxin Li

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Ronald S Duman

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Rong-Jian Liu

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Vanja Duric

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P2860

Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase

Synaptic AMPA receptor plasticity and behavior.

A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depression

mTOR signaling: at the crossroads of plasticity, memory and disease

Positive AMPA receptor modulation rapidly stimulates BDNF release and increases dendritic mRNA translation

The molecular neurobiology of depression

Stress blunts serotonin- and hypocretin-evoked EPSCs in prefrontal cortex: role of corticosterone-mediated apical dendritic atrophy

Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior

Effects of the potent ampakine CX614 on hippocampal and recombinant AMPA receptors: interactions with cyclothiazide and GYKI 52466

RNAi reveals doublecortin is required for radial migration in rat neocortex

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