Multiplexed metagenome mining using short DNA sequence tags facilitates targeted discovery of epoxyketone proteasome inhibitors
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Accessing Nature's diversity through metabolic engineering and synthetic biologyMetabolic network-guided binning of metagenomic sequence fragments.Mass spectrometry tools and workflows for revealing microbial chemistry.Yeast homologous recombination-based promoter engineering for the activation of silent natural product biosynthetic gene clusters.Use of Redundant Exclusion PCR To Identify a Novel Bacillus thuringiensis Cry8 Toxin Gene from Pooled Genomic DNA.Urban park soil microbiomes are a rich reservoir of natural product biosynthetic diversityUsing natural products for drug discovery: the impact of the genomics era.Natural product discovery from the human microbiome.Digitizing mass spectrometry data to explore the chemical diversity and distribution of marine cyanobacteria and algae.Identifying the Minimal Enzymes Required for Biosynthesis of Epoxyketone Proteasome Inhibitors.Culture-independent discovery of natural products from soil metagenomes.The evolution of genome mining in microbes - a review.Genomic and functional techniques to mine the microbiome for novel antimicrobials and antimicrobial resistance genes.Natural products, their derivatives, mimics and synthetic equivalents: role in agrochemical discovery.Biosynthesis of the β-Lactone Proteasome Inhibitors Belactosin and Cystargolide.Epoxomicin and Eponemycin Biosynthesis Involves gem-Dimethylation and an Acyl-CoA Dehydrogenase-Like Enzyme.Biotechnological potential of Actinobacteria from Canadian and Azorean volcanic caves.Filamentous fungi from extreme environments as a promising source of novel bioactive secondary metabolitesGenerate a bioactive natural product library by mining bacterial cytochrome P450 patterns.Discovery of the leinamycin family of natural products by mining actinobacterial genomes.Secondary metabolism in the lichen symbiosis.Bacterial natural product biosynthetic domain composition in soil correlates with changes in latitude on a continent-wide scale.Culture-independent discovery of the malacidins as calcium-dependent antibiotics with activity against multidrug-resistant Gram-positive pathogens.Discovery of the Tyrobetaine Natural Products and Their Biosynthetic Gene Cluster via Metabologenomics.Concepts and Methods to Access Novel Antibiotics from Actinomycetes.Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism
P2860
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P2860
Multiplexed metagenome mining using short DNA sequence tags facilitates targeted discovery of epoxyketone proteasome inhibitors
description
2015 nî lūn-bûn
@nan
2015 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի մարտին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Multiplexed metagenome mining ...... xyketone proteasome inhibitors
@ast
Multiplexed metagenome mining ...... xyketone proteasome inhibitors
@en
type
label
Multiplexed metagenome mining ...... xyketone proteasome inhibitors
@ast
Multiplexed metagenome mining ...... xyketone proteasome inhibitors
@en
prefLabel
Multiplexed metagenome mining ...... xyketone proteasome inhibitors
@ast
Multiplexed metagenome mining ...... xyketone proteasome inhibitors
@en
P2093
P2860
P356
P1476
Multiplexed metagenome mining ...... xyketone proteasome inhibitors
@en
P2093
Alexandra G Smith
Boojala Vijay B Reddy
Daniel Montiel
Jeremy G Owen
Melinda A Ternei
Paula Y Calle
Sean F Brady
Zachary Charlop-Powers
P2860
P304
P356
10.1073/PNAS.1501124112
P407
P577
2015-03-23T00:00:00Z