Loss of protease dimerization inhibition activity of darunavir is associated with the acquisition of resistance to darunavir by HIV-1.

Loss of protease dimerization inhibition activity of darunavir is associated with the acquisition of resistance to darunavir by HIV-1.

Item
http://www.wikidata.org/entity/Q35382383
Unique Flap Conformation in an HIV-1 Protease with High-Level Darunavir Resistance.Understanding HIV-1 protease autoprocessing for novel therapeutic development.Dimerization of HIV-1 protease occurs through two steps relating to the mechanism of protease dimerization inhibition by darunavir.Loss of the protease dimerization inhibition activity of tipranavir (TPV) and its association with the acquisition of resistance to TPV by HIV-1.Design of HIV-1 Protease Inhibitors with Amino-bis-tetrahydrofuran Derivatives as P2-Ligands to Enhance Backbone-Binding Interactions: Synthesis, Biological Evaluation, and Protein-Ligand X-ray StudiesC-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, including DarunavirSelection of drug-resistant feline immunodeficiency virus (FIV) encoding FIV/HIV chimeric protease in the presence of HIV-specific protease inhibitorsDarunavir: a review of its use in the management of HIV-1 infection.Darunavir: A Review in Pediatric HIV-1 Infection.Recent Progress in the Development of HIV-1 Protease Inhibitors for the Treatment of HIV/AIDSFlexible catalytic site conformations implicated in modulation of HIV-1 protease autoprocessing reactions.Evaluation of novel protease inhibitors against darunavir-resistant variants of HIV type 1.A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency.FRET analysis of HIV-1 Gag and GagPol interactions.Design of Highly Potent, Dual Acting and Central Nervous System Penetrating HIV-1 Protease Inhibitors with Excellent Potency against Multidrug-Resistant HIV-1 Variants.Mechanism of Darunavir (DRV)'s High Genetic Barrier to HIV-1 Resistance: A Key V32I Substitution in Protease Rarely Occurs, but Once It Occurs, It Predisposes HIV-1 To Develop DRV Resistance.
P2860

Loss of protease dimerization inhibition activity of darunavir is associated with the acquisition of resistance to darunavir by HIV-1.

Item
http://www.wikidata.org/entity/Q35382383
description
2011 nî lūn-bûn
@nan
2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
name
Loss of protease dimerization ...... istance to darunavir by HIV-1.
@ast
Loss of protease dimerization ...... istance to darunavir by HIV-1.
@en
type
label
Loss of protease dimerization ...... istance to darunavir by HIV-1.
@ast
Loss of protease dimerization ...... istance to darunavir by HIV-1.
@en
prefLabel
Loss of protease dimerization ...... istance to darunavir by HIV-1.
@ast
Loss of protease dimerization ...... istance to darunavir by HIV-1.
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698
P932
P356
P1433
P1476
Loss of protease dimerization ...... sistance to darunavir by HIV-1
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698
P932