Mapping of herpes simplex virus 1 genes with mutations which overcome host restrictions to infection
about
The ectodomain of a novel member of the immunoglobulin subfamily related to the poliovirus receptor has the attributes of a bona fide receptor for herpes simplex virus types 1 and 2 in human cellsNectin2alpha (PRR2alpha or HveB) and nectin2delta are low-efficiency mediators for entry of herpes simplex virus mutants carrying the Leu25Pro substitution in glycoprotein DThe V domain of herpesvirus Ig-like receptor (HIgR) contains a major functional region in herpes simplex virus-1 entry into cells and interacts physically with the viral glycoprotein DTrafficking to the plasma membrane of the seven-transmembrane protein encoded by human herpesvirus 6 U51 gene involves a cell-specific function present in T lymphocytes.A herpes simplex virus recombinant that exhibits a single-chain antibody to HER2/neu enters cells through the mammary tumor receptor, independently of the gD receptors.The domains of glycoprotein D required to block apoptosis induced by herpes simplex virus 1 are largely distinct from those involved in cell-cell fusion and binding to nectin1Cross talk among the glycoproteins involved in herpes simplex virus entry and fusion: the interaction between gB and gH/gL does not necessarily require gD.The murine homolog of human Nectin1delta serves as a species nonspecific mediator for entry of human and animal alpha herpesviruses in a pathway independent of a detectable binding to gDMutations in the N termini of herpes simplex virus type 1 and 2 gDs alter functional interactions with the entry/fusion receptors HVEM, nectin-2, and 3-O-sulfated heparan sulfate but not with nectin-1.Viral determinants of the variable sensitivity of herpes simplex virus strains to gD-mediated interferenceStructure-function analysis of soluble forms of herpes simplex virus glycoprotein D.Antigenic structure of soluble herpes simplex virus (HSV) glycoprotein D correlates with inhibition of HSV infectionCharacterization of a BHK(TK-) cell clone resistant to postattachment entry by herpes simplex virus types 1 and 2Anti-idiotypic antibodies mimicking glycoprotein D of herpes simplex virus identify a cellular protein required for virus spread from cell to cell and virus-induced polykaryocytosis.Herpes simplex virus infects most cell types in vitro: clues to its successMutations in herpes simplex virus glycoprotein D distinguish entry of free virus from cell-cell spread.Herpesvirus entry mediator HVEM mediates cell-cell spread in BHK(TK-) cell clones.Substitution in the murine nectin1 receptor of a single conserved amino acid at a position distal from the herpes simplex virus gD binding site confers high-affinity binding to gD.Herpes simplex virus glycoprotein K, but not its syncytial allele, inhibits cell-cell fusion mediated by the four fusogenic glycoproteins, gD, gB, gH, and gL.Generation of herpesvirus entry mediator (HVEM)-restricted herpes simplex virus type 1 mutant viruses: resistance of HVEM-expressing cells and identification of mutations that rescue nectin-1 recognitionDevelopment of pseudorabies virus strains expressing red fluorescent proteins: new tools for multisynaptic labeling applications.Coexpression of UL20p and gK inhibits cell-cell fusion mediated by herpes simplex virus glycoproteins gD, gH-gL, and wild-type gB or an endocytosis-defective gB mutant and downmodulates their cell surface expression.The herpes simplex virus JMP mutant enters receptor-negative J cells through a novel pathway independent of the known receptors nectin1, HveA, and nectin2.Herpes simplex virus gD forms distinct complexes with fusion executors gB and gH/gL in part through the C-terminal profusion domain.Spotlight on… Gabriella Campadelli-Fiume.
P2860
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P2860
Mapping of herpes simplex virus 1 genes with mutations which overcome host restrictions to infection
description
1994 nî lūn-bûn
@nan
1994 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Mapping of herpes simplex viru ...... host restrictions to infection
@ast
Mapping of herpes simplex viru ...... host restrictions to infection
@en
type
label
Mapping of herpes simplex viru ...... host restrictions to infection
@ast
Mapping of herpes simplex viru ...... host restrictions to infection
@en
prefLabel
Mapping of herpes simplex viru ...... host restrictions to infection
@ast
Mapping of herpes simplex viru ...... host restrictions to infection
@en
P2093
P2860
P356
P1476
Mapping of herpes simplex viru ...... host restrictions to infection
@en
P2093
G Campadelli-Fiume
R Brandimarti
P2860
P304
P356
10.1073/PNAS.91.12.5406
P407
P577
1994-06-01T00:00:00Z