Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice - Wikidata - wikimedia - TriplyDB

Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice

Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice

http://www.wikidata.org/entity/Q35483789

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Hemojuvelin and bone morphogenetic protein (BMP) signaling in iron homeostasis HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression Regulation of Iron Metabolism by Hepcidin under Conditions of Inflammation Hepcidin and iron homeostasis Murine mutants in the study of systemic iron metabolism and its disorders: an update on recent advances Mechanisms of mammalian iron homeostasis Modulation of hepcidin as therapy for primary and secondary iron overload disorders: preclinical models and approaches Bmp6 expression in murine liver non parenchymal cells: a mechanism to control their high iron exporter activity and protect hepatocytes from iron overload?Molecular basis of HFE-hemochromatosis.Iron regulation by hepcidin Identification of TMPRSS6 cleavage sites of hemojuvelin Pathophysiological consequences and benefits of HFE mutations: 20 years of research.MicroRNA-130a is up-regulated in mouse liver by iron deficiency and targets the bone morphogenetic protein (BMP) receptor ALK2 to attenuate BMP signaling and hepcidin transcription.BMP type II receptors have redundant roles in the regulation of hepatic hepcidin gene expression and iron metabolism Duodenal absorption and tissue utilization of dietary heme and nonheme iron differ in rats.Hepcidin regulation by BMP signaling in macrophages is lipopolysaccharide dependent.Repulsive guidance molecule (RGM) family proteins exhibit differential binding kinetics for bone morphogenetic proteins (BMPs)Bone Morphogenetic Protein (BMP) signaling in development and human diseases Specific activin receptor-like kinase 3 inhibitors enhance liver regeneration Increased iron loading induces Bmp6 expression in the non-parenchymal cells of the liver independent of the BMP-signaling pathway.Low intracellular iron increases the stability of matriptase-2.Relationship of Baseline Hemoglobin Level with Serum Ferritin, Postphlebotomy Hemoglobin Changes, and Phlebotomy Requirements among HFE C282Y Homozygotes Intravenous Iron Carboxymaltose as a Potential Therapeutic in Anemia of Inflammation.Impaired hepcidin expression in alpha-1-antitrypsin deficiency associated with iron overload and progressive liver disease.Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.CYBRD1 as a modifier gene that modulates iron phenotype in HFE p.C282Y homozygous patients.Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice.Identification and characterization of a novel murine allele of Tmprss6.A hepcidin lowering agent mobilizes iron for incorporation into red blood cells in an adenine-induced kidney disease model of anemia in rats.Transforming Growth Factor β1 (TGF-β1) Activates Hepcidin mRNA Expression in Hepatocytes Neogenin Facilitates the Induction of Hepcidin Expression by Hemojuvelin in the Liver.Out of balance--systemic iron homeostasis in iron-related disorders The liver: conductor of systemic iron balance.Development of an ALK2-biased BMP type I receptor kinase inhibitor.The iron cycle in chronic kidney disease (CKD): from genetics and experimental models to CKD patients.The Regulation of Iron Absorption and Homeostasis.Angiocrine Bmp2 signaling in murine liver controls normal iron homeostasis The type I BMP receptor Alk3 is required for the induction of hepatic hepcidin gene expression by interleukin-6.Targeting the hepcidin-ferroportin axis to develop new treatment strategies for anemia of chronic disease and anemia of inflammation.Repulsive guidance molecules (RGMs) and neogenin in bone morphogenetic protein (BMP) signaling.

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Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice

http://www.wikidata.org/entity/Q35483789

description

2011 nî lūn-bûn

@nan

2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2011年の論文

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2011年論文

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2011年論文

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2011年論文

@zh-hk

2011年論文

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2011年論文

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2011年论文

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name

Perturbation of hepcidin expre ...... induces iron overload in mice

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Perturbation of hepcidin expre ...... induces iron overload in mice

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type

label

Perturbation of hepcidin expre ...... induces iron overload in mice

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Perturbation of hepcidin expre ...... induces iron overload in mice

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Perturbation of hepcidin expre ...... induces iron overload in mice

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Perturbation of hepcidin expre ...... induces iron overload in mice

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Perturbation of hepcidin expre ...... induces iron overload in mice

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Alexandra E Pappas

http://www.w3.org/2001/XMLSchema#string

Andrea U Steinbicker

http://www.w3.org/2001/XMLSchema#string

Claire Mayeur

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Donald B Bloch

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Kenneth D Bloch

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Lisa K Lohmeyer

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Patricio Leyton

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Randall T Peterson

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Sonya M Kao

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Thomas B Bartnikas

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P2860

Signal transduction of bone morphogenetic protein receptors

Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

A mouse model of juvenile hemochromatosis.

Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis

The flatiron mutation in mouse ferroportin acts as a dominant negative to cause ferroportin disease

Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance

A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload

Iron regulatory proteins and the molecular control of mammalian iron metabolism

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4224-4230

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10.1182/BLOOD-2011-03-339952

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3204739

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