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Sphingosine kinase inhibitors and cancer: seeking the golden sword of Hercules

Sphingosine kinase inhibitors and cancer: seeking the golden sword of Hercules

http://www.wikidata.org/entity/Q35501532

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Sphingosine kinase 1 is a reliable prognostic factor and a novel therapeutic target for uterine cervical cancer.Metabolic profiling reveals sphingosine-1-phosphate kinase 2 and lyase as key targets of (phyto-) estrogen action in the breast cancer cell line MCF-7 and not in MCF-12A Biological characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a selective sphingosine kinase-2 inhibitor and anticancer agent Sphingosine 1-Phosphate Activation of EGFR As a Novel Target for Meningitic Escherichia coli Penetration of the Blood-Brain Barrier Effect of alkyl chain length on sphingosine kinase 2 selectivity.The impact of sphingosine kinase-1 in head and neck cancer.Sphingosine analog fingolimod (FTY720) increases radiation sensitivity of human breast cancer cells in vitro Sphingosine kinase 1 in cancer.Bringing balance by force: live cell extrusion controls epithelial cell numbers Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond.TGFβ-Mediated induction of SphK1 as a potential determinant in human MDA-MB-231 breast cancer cell bone metastasis.A sphingosine kinase inhibitor combined with temozolomide induces glioblastoma cell death through accumulation of dihydrosphingosine and dihydroceramide, endoplasmic reticulum stress and autophagy Targeting sphingosine kinase 2 (SphK2) by ABC294640 inhibits colorectal cancer cell growth in vitro and in vivo.Dengue Virus-Induced Inflammation of the Endothelium and the Potential Roles of Sphingosine Kinase-1 and MicroRNAs.The impact of sphingosine kinase inhibitor-loaded nanoparticles on bioelectrical and biomechanical properties of cancer cells.Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis.Essential role for SphK1/S1P signaling to regulate hypoxia-inducible factor 2α expression and activity in cancer.Targeting survival pathways in chronic myeloid leukaemia stem cells Sphingosine kinase 1 in viral infections.Major apoptotic mechanisms and genes involved in apoptosis.Impact of acetylation on tumor metabolism.Sphingosine 1-phosphate signaling impacts lymphocyte migration, inflammation and infection.Therapeutic Strategies and Pharmacological Tools Influencing S1P Signaling and Metabolism.Sphingosine kinase 1 as a potential therapeutic target in epithelial ovarian cancer.Involvement of vacuolar H(+)-ATPase in killing of human melanoma cells by the sphingosine kinase analogue FTY720.The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism.Synthesis of (S)-FTY720 vinylphosphonate analogues and evaluation of their potential as sphingosine kinase 1 inhibitors and activators.NMR metabolomics highlights sphingosine kinase-1 as a new molecular switch in the orchestration of aberrant metabolic phenotype in cancer cells.Pharmacokinetics of Jaspine B and Enhancement of Intestinal Absorption of Jaspine B in the Presence of Bile Acid in Rats.Inhibition of dihydroceramide desaturase activity by the sphingosine kinase inhibitor SKI II.Novel sphingosine-containing analogues selectively inhibit sphingosine kinase (SK) isozymes, induce SK1 proteasomal degradation and reduce DNA synthesis in human pulmonary arterial smooth muscle cells.Sphingosine kinase: a key to solving the 'French Paradox'?D-Glucosamine-derived synthons for assembly of L-threo-sphingoid bases. Total synthesis of rhizochalinin C.Regulation of cell survival by sphingosine-1-phosphate receptor S1P1 via reciprocal ERK-dependent suppression of Bim and PI-3-kinase/protein kinase C-mediated upregulation of Mcl-1.FTY720 (Fingolimod) sensitizes hepatocellular carcinoma cells to sorafenib-mediated cytotoxicity.Sphingosine kinase 1 enables communication between melanoma cells and fibroblasts that provides a new link to metastasis.Identification of novel functional and spatial associations between sphingosine kinase 1, sphingosine 1-phosphate receptors and other signaling proteins that affect prognostic outcome in estrogen receptor-positive breast cancer.The sphingosine kinase 2 inhibitor ABC294640 inhibits cervical carcinoma cell growth.LRIG1 modulates aggressiveness of head and neck cancers by regulating EGFR-MAPK-SPHK1 signaling and extracellular matrix remodeling.New extracellular factors in glioblastoma multiforme development: neurotensin, growth differentiation factor-15, sphingosine-1-phosphate and cytomegalovirus infection.

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P2860

Sphingosine kinase inhibitors and cancer: seeking the golden sword of Hercules

http://www.wikidata.org/entity/Q35501532

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2011 nî lūn-bûn

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2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Sphingosine kinase inhibitors and cancer: seeking the golden sword of Hercules

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Sphingosine kinase inhibitors and cancer: seeking the golden sword of Hercules

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Sphingosine kinase inhibitors and cancer: seeking the golden sword of Hercules

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Sphingosine kinase inhibitors and cancer: seeking the golden sword of Hercules

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Sphingosine kinase inhibitors and cancer: seeking the golden sword of Hercules

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0008-5472.CAN-11-2364

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Cancer Research

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Sphingosine kinase inhibitors and cancer: seeking the golden sword of Hercules

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P2093

Nigel J Pyne

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Robert Bittman

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Susan Pyne

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P2860

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

Progesterone-induced sphingosine kinase-1 expression in the rat uterus during pregnancy and signaling consequences

Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells.

Discovery and evaluation of inhibitors of human sphingosine kinase.

Pharmacological inhibition of sphingosine kinase isoforms alters estrogen receptor signaling in human breast cancer.

Pharmacology and antitumor activity of ABC294640, a selective inhibitor of sphingosine kinase-2

Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.

A novel sphingosine kinase inhibitor induces autophagy in tumor cells.

Sphingosine kinase 1 induces tolerance to human epidermal growth factor receptor 2 and prevents formation of a migratory phenotype in response to sphingosine 1-phosphate in estrogen receptor-positive breast cancer cells.

Sphingosine 1-phosphate and cancer.

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6576-6582

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scholarly article

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10.1158/0008-5472.CAN-11-2364

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21

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71

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2011-09-22T00:00:00Z

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3206172

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