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Targeting p97 to Disrupt Protein Homeostasis in CancerStructure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPaseCovalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell deathDendrimer-Based Selective Proteostasis-Inhibition Strategy to Control NSCLC Growth and ProgressionA non-canonical role of the p97 complex in RIG-I antiviral signalingSpecific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domainsEvaluating p97 inhibitor analogues for their domain selectivity and potency against the p97-p47 complex.Combined inhibition of p97 and the proteasome causes lethal disruption of the secretory apparatus in multiple myeloma cells.A novel UGGT1 and p97-dependent checkpoint for native ectodomains with ionizable intramembrane residueThe VCP/p97 and YOD1 Proteins Have Different Substrate-dependent Activities in Endoplasmic Reticulum-associated Degradation (ERAD)Inadequate fine-tuning of protein synthesis and failure of amino acid homeostasis following inhibition of the ATPase VCP/p97VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease.Cdc48: a swiss army knife of cell biology.Perturbations to the ubiquitin conjugate proteome in yeast δubx mutants identify Ubx2 as a regulator of membrane lipid composition.Targeting VCP enhances anticancer activity of oncolytic virus M1 in hepatocellular carcinoma.Valosin-containing protein (VCP)-Adaptor Interactions are Exceptionally Dynamic and Subject to Differential Modulation by a VCP Inhibitor.The drug diazaborine blocks ribosome biogenesis by inhibiting the AAA-ATPase Drg1.Ubiquitin turnover and endocytic trafficking in yeast are regulated by Ser57 phosphorylation of ubiquitin.An engineered, quantifiable in vitro model for analysing the effect of proteostasis-targeting drugs on tissue physical properties
P2860
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P2860
description
2011 nî lūn-bûn
@nan
2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Development of p97 AAA ATPase inhibitors.
@ast
Development of p97 AAA ATPase inhibitors.
@en
type
label
Development of p97 AAA ATPase inhibitors.
@ast
Development of p97 AAA ATPase inhibitors.
@en
prefLabel
Development of p97 AAA ATPase inhibitors.
@ast
Development of p97 AAA ATPase inhibitors.
@en
P356
P1433
P1476
Development of p97 AAA ATPase inhibitors.
@en
P2093
Raymond J Deshaies
Tsui-Fen Chou
P304
P356
10.4161/AUTO.7.9.16489
P577
2011-09-01T00:00:00Z