Mutations in the MutSalpha interaction interface of MLH1 can abolish DNA mismatch repair. - Wikidata - wikimedia - TriplyDB

Mutations in the MutSalpha interaction interface of MLH1 can abolish DNA mismatch repair.

Mutations in the MutSalpha interaction interface of MLH1 can abolish DNA mismatch repair.

http://www.wikidata.org/entity/Q35537125

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Refining the role of PMS2 in Lynch syndrome: germline mutational analysis improved by comprehensive assessment of variants DNA triplet repeat expansion and mismatch repair Structure of the endonuclease domain of MutL: unlicensed to cut.Postreplicative mismatch repair.DNA repair mechanisms and the bypass of DNA damage in Saccharomyces cerevisiae Chemical trapping of the dynamic MutS-MutL complex formed in DNA mismatch repair in Escherichia coli.A conserved MutS homolog connector domain interface interacts with MutL homologs.MutLalpha and proliferating cell nuclear antigen share binding sites on MutSbeta.C-terminal fluorescent labeling impairs functionality of DNA mismatch repair proteins.A novel and rapid method of determining the effect of unclassified MLH1 genetic variants on differential allelic expression DNA methyltransferases, DNA damage repair, and cancer Chimeric Saccharomyces cerevisiae Msh6 protein with an Msh3 mispair-binding domain combines properties of both proteins.The sliding clamp tethers the endonuclease domain of MutL to DNA Characterization of a highly conserved binding site of Mlh1 required for exonuclease I-dependent mismatch repair.Elucidating the clinical significance of two PMS2 missense variants coexisting in a family fulfilling hereditary cancer criteria.Functional testing strategy for coding genetic variants of unclear significance in MLH1 in Lynch syndrome diagnosis.Determining the functional significance of mismatch repair gene missense variants using biochemical and cellular assays.Rapid generation of rice mutants via the dominant negative suppression of the mismatch repair protein OsPMS1.Identification of Lynch syndrome mutations in the MLH1-PMS2 interface that disturb dimerization and mismatch repair.Evaluation of the MLH1 I219V alteration in DNA mismatch repair activity and ulcerative colitis.Single-molecule multiparameter fluorescence spectroscopy reveals directional MutS binding to mismatched bases in DNA Missense variants in hMLH1 identified in patients from the German HNPCC consortium and functional studies.Comprehensive functional assessment of MLH1 variants of unknown significance.Trapping and visualizing intermediate steps in the mismatch repair pathway in vivo.The MLH1 ATPase domain is needed for suppressing aberrant formation of interstitial telomeric sequences.

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Mutations in the MutSalpha interaction interface of MLH1 can abolish DNA mismatch repair.

http://www.wikidata.org/entity/Q35537125

description

2006 nî lūn-bûn

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2006 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

Mutations in the MutSalpha interaction interface of MLH1 can abolish DNA mismatch repair.

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Mutations in the MutSalpha interaction interface of MLH1 can abolish DNA mismatch repair.

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type

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Mutations in the MutSalpha interaction interface of MLH1 can abolish DNA mismatch repair.

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Mutations in the MutSalpha interaction interface of MLH1 can abolish DNA mismatch repair.

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Mutations in the MutSalpha interaction interface of MLH1 can abolish DNA mismatch repair.

@ast

Mutations in the MutSalpha interaction interface of MLH1 can abolish DNA mismatch repair.

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P1433

Nucleic Acids Research

P1476

Mutations in the MutSalpha interaction interface of MLH1 can abolish DNA mismatch repair.

@en

P2093

Christoph Welsch

http://www.w3.org/2001/XMLSchema#string

Guido Plotz

http://www.w3.org/2001/XMLSchema#string

Jochen Raedle

http://www.w3.org/2001/XMLSchema#string

Luis Giron-Monzon

http://www.w3.org/2001/XMLSchema#string

Mario Albrecht

http://www.w3.org/2001/XMLSchema#string

Peter Friedhoff

http://www.w3.org/2001/XMLSchema#string

Ricardo M Biondi

http://www.w3.org/2001/XMLSchema#string

P2860

MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability

hMutSalpha forms an ATP-dependent complex with hMutLalpha and hMutLbeta on DNA.

A defined human system that supports bidirectional mismatch-provoked excision

Mechanism of 5'-directed excision in human mismatch repair

Analysis of the human MutLalpha.MutSalpha complex

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

Multiple sequence alignment with the Clustal series of programs

N-terminus of hMLH1 confers interaction of hMutLalpha and hMutLbeta with hMutSalpha

ConSurf 2005: the projection of evolutionary conservation scores of residues on protein structures

Transformation of MutL by ATP binding and hydrolysis: a switch in DNA mismatch repair

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6574-6586

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scholarly article

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10.1093/NAR/GKL944

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22

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34

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Thomas Lengauer

Albrecht Piiper

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2006-11-28T00:00:00Z

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6663901

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1747184

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