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Distributing a metabolic pathway among a microbial consortium enhances production of natural products.

Distributing a metabolic pathway among a microbial consortium enhances production of natural products.

http://www.wikidata.org/entity/Q35537845

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Gas Fermentation-A Flexible Platform for Commercial Scale Production of Low-Carbon-Fuels and Chemicals from Waste and Renewable Feedstocks Accessing Nature's diversity through metabolic engineering and synthetic biology Utilization and control of ecological interactions in polymicrobial infections and community-based microbial cell factories Recent advances in biosynthesis of bioactive compounds in traditional Chinese medicinal plants Synthetic Ecology of Microbes: Mathematical Models and Applications Synthetic biology expands chemical control of microorganisms Engineering Escherichia coli coculture systems for the production of biochemical products.Engineered biosynthesis of natural products in heterologous hosts Reorganization of a synthetic microbial consortium for one-step vitamin C fermentation.High-throughput evaluation of synthetic metabolic pathways.New tools for reconstruction and heterologous expression of natural product biosynthetic gene clusters.Total biosynthesis of opiates by stepwise fermentation using engineered Escherichia coli.Overcoming heterologous protein interdependency to optimize P450-mediated Taxol precursor synthesis in Escherichia coli.Comparative genomics analysis of the companion mechanisms of Bacillus thuringiensis Bc601 and Bacillus endophyticus Hbe603 in bacterial consortium.Engineering biosynthesis of the anticancer alkaloid noscapine in yeast.Engineering microbial consortia for controllable outputs Photosynthetic conversion of CO2 to farnesyl diphosphate-derived phytochemicals (amorpha-4,11-diene and squalene) by engineered cyanobacteria.Novel co-culture plate enables growth dynamic-based assessment of contact-independent microbial interactions.Principles for designing synthetic microbial communities.Production of taxadiene by engineering of mevalonate pathway in Escherichia coli and endophytic fungus Alternaria alternata TPF6.Synthetic microbial ecology and the dynamic interplay between microbial genotypes.Cooperation in microbial communities and their biotechnological applications.Opportunities and challenges for the sustainable production of structurally complex diterpenoids in recombinant microbial systems.Maximizing the stability of metabolic engineering-derived whole-cell biocatalysts.Comparative analysis of L-sorbose dehydrogenase by docking strategy for 2-keto-L-gulonic acid production in Ketogulonicigenium vulgare and Bacillus endophyticus consortium.Transcriptome Assembly and Systematic Identification of Novel Cytochrome P450s in Taxus chinensis.Complete Biosynthesis of Anthocyanins Using E. coli Polycultures.Engineering E. coli-E. coli cocultures for production of muconic acid from glycerol.Total biosynthesis of the cyclic AMP booster forskolin from Coleus forskohlii.Design and construction of synthetic microbial consortia in China.Challenges and Advances for Genetic Engineering of Non-model Bacteria and Uses in Consolidated Bioprocessing.Yeast Creates a Niche for Symbiotic Lactic Acid Bacteria through Nitrogen Overflow.Constructing "quantized quorums" to guide emergent phenotypes through quorum quenching capsules.Design, analysis and application of synthetic microbial consortia.Metabolic characterization of anaerobic fungi provides a path forward for bioprocessing of crude lignocellulose.A bioarchitectonic approach to the modular engineering of metabolism.Versatile and on-demand biologics co-production in yeast.Diversifying Natural Products with Promiscuous Glycosyltransferase Enzymes via a Sustainable Microbial Fermentation Approach.Heterologous biosynthesis of natural product naringenin by co-culture engineering.Engineering Escherichia coli for malate production by integrating modular pathway characterization with CRISPRi-guided multiplexed metabolic tuning.

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P2860

Distributing a metabolic pathway among a microbial consortium enhances production of natural products.

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Nature Biotechnology

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Gregory Stephanopoulos

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Kang Zhou

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Kangjian Qiao

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Steven Edgar

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P2860

Five rules for the evolution of cooperation

Isoprenoid pathway optimization for Taxol precursor overproduction in Escherichia coli

Cloning and disruption of a gene required for growth on acetate but not on ethanol: the acetyl-coenzyme A synthetase gene of Saccharomyces cerevisiae.

Taxol biosynthesis: differential transformations of taxadien-5 alpha-ol and its acetate ester by cytochrome P450 hydroxylases from Taxus suspension cells

High-level semi-synthetic production of the potent antimalarial artemisinin

Cytochrome P450-catalyzed hydroxylation of taxa-4(5),11(12)-diene to taxa-4(20),11(12)-dien-5alpha-ol: the first oxygenation step in taxol biosynthesis

Enhancing isoprene production by genetic modification of the 1-deoxy-d-xylulose-5-phosphate pathway in Bacillus subtilis

Molecular cloning of a taxa-4(20),11(12)-dien-5alpha-ol-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coli.

Synthesis of methyl halides from biomass using engineered microbes.

Cytochrome p450 taxadiene 5alpha-hydroxylase, a mechanistically unusual monooxygenase catalyzing the first oxygenation step of taxol biosynthesis.

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377-383

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10.1038/NBT.3095

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4

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