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The mTOR inhibitor rapamycin suppresses DNA double-strand break repair

The mTOR inhibitor rapamycin suppresses DNA double-strand break repair

http://www.wikidata.org/entity/Q35545852

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Skin cancer in organ transplant recipients: effects of immunosuppressive medications on DNA repair Radiotherapy and "new" drugs-new side effects?Eukaryotic initiation factor 2α--a downstream effector of mammalian target of rapamycin--modulates DNA repair and cancer response to treatment Single molecule PCR reveals similar patterns of non-homologous DSB repair in tobacco and Arabidopsis.Role of radiation therapy in the management of renal cell cancer Concurrent versus sequential sorafenib therapy in combination with radiation for hepatocellular carcinoma.53BP1 promotes microhomology-mediated end-joining in G1-phase cells.Tumor cells switch to mitochondrial oxidative phosphorylation under radiation via mTOR-mediated hexokinase II inhibition--a Warburg-reversing effect The novel chemical entity YTR107 inhibits recruitment of nucleophosmin to sites of DNA damage, suppressing repair of DNA double-strand breaks and enhancing radiosensitization A dual role of BRCA1 in two distinct homologous recombination mediated repair in response to replication arrest.The TMPRSS2-ERG Gene Fusion Blocks XRCC4-Mediated Nonhomologous End-Joining Repair and Radiosensitizes Prostate Cancer Cells to PARP Inhibition Dual Targeting of Akt and mTORC1 Impairs Repair of DNA Double-Strand Breaks and Increases Radiation Sensitivity of Human Tumor Cells.Rapamycin-induced autophagy sensitizes A549 cells to radiation associated with DNA damage repair inhibition.DNA Damage Response Assessments in Human Tumor Samples Provide Functional Biomarkers of Radiosensitivity.[Role of Autophagy in the Radiosensitivity of Human Lung Adenocarcinoma A549 Cells].DNA damage checkpoint triggers autophagy to regulate the initiation of anaphase.RNF126 promotes homologous recombination via regulation of E2F1-mediated BRCA1 expression BRCA1 inhibits AR-mediated proliferation of breast cancer cells through the activation of SIRT1 Single-cell microarray enables high-throughput evaluation of DNA double-strand breaks and DNA repair inhibitors.Protein phosphatase 2A and DNA-dependent protein kinase are involved in mediating rapamycin-induced Akt phosphorylation.mTOR Inhibitors Suppress Homologous Recombination Repair and Synergize with PARP Inhibitors via Regulating SUV39H1 in BRCA-Proficient Triple-Negative Breast Cancer.Regulation of FANCD2 by the mTOR pathway contributes to the resistance of cancer cells to DNA double-strand breaks p53 suppresses hyper-recombination by modulating BRCA1 function.Targeting radioresistant breast cancer cells by single agent CHK1 inhibitor via enhancing replication stress.Doubling down on the PI3K-AKT-mTOR pathway enhances the antitumor efficacy of PARP inhibitor in triple negative breast cancer model beyond BRCA-ness Calories, carbohydrates, and cancer therapy with radiation: exploiting the five R's through dietary manipulation.The interplay between DNA repair and autophagy in cancer therapy Enhancement of mTOR signaling contributes to acquired X-ray and C-ion resistance in mouse squamous carcinoma cell line.Simultaneous perturbation of the MAPK and the PI3K/mTOR pathways does not lead to increased radiosensitization.The Akt inhibitor MK-2206 enhances the cytotoxicity of paclitaxel (Taxol) and cisplatin in ovarian cancer cells.mTOR inhibitors radiosensitize PTEN-deficient non-small-cell lung cancer cells harboring an EGFR activating mutation by inducing autophagy.Chronic modulation of AMP-Kinase, Akt and mTOR pathways by ionizing radiation in human lung cancer xenografts.Radiosensitization of Glioblastoma Cell Lines by the Dual PI3K and mTOR Inhibitor NVP-BEZ235 Depends on Drug-Irradiation Schedule.mTOR is a selective effector of the radiation therapy response in androgen receptor-positive prostate cancer Radiation-induced esophagitis exacerbated by everolimus.Rapamycin sensitizes cancer cells to growth inhibition by the PARP inhibitor olaparib.Synergy of WEE1 and mTOR Inhibition in Mutant KRAS-Driven Lung Cancers.Acquired resistance to tyrosine kinase inhibitors may be linked with the decreased sensitivity to X-ray irradiation.

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The mTOR inhibitor rapamycin suppresses DNA double-strand break repair

http://www.wikidata.org/entity/Q35545852

description

2010 nî lūn-bûn

@nan

2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

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2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

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2010年論文

@zh-tw

2010年论文

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name

The mTOR inhibitor rapamycin suppresses DNA double-strand break repair

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The mTOR inhibitor rapamycin suppresses DNA double-strand break repair

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type

label

The mTOR inhibitor rapamycin suppresses DNA double-strand break repair

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The mTOR inhibitor rapamycin suppresses DNA double-strand break repair

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prefLabel

The mTOR inhibitor rapamycin suppresses DNA double-strand break repair

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The mTOR inhibitor rapamycin suppresses DNA double-strand break repair

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P1433

Radiation Research

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The mTOR inhibitor rapamycin suppresses DNA double-strand break repair

@en

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Honghong Chen

http://www.w3.org/2001/XMLSchema#string

Ignacio Gonzalez-Suarez

http://www.w3.org/2001/XMLSchema#string

Jiuqin Zhang

http://www.w3.org/2001/XMLSchema#string

Joseph L Roti Roti

http://www.w3.org/2001/XMLSchema#string

Junran Zhang

http://www.w3.org/2001/XMLSchema#string

Robert P Vanderwaal

http://www.w3.org/2001/XMLSchema#string

Shenming Wang

http://www.w3.org/2001/XMLSchema#string

Susana Gonzalo

http://www.w3.org/2001/XMLSchema#string

Zhefu Ma

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Zhihui Feng

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DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes

XRCC3 promotes homology-directed repair of DNA damage in mammalian cells

Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair

Megabase chromatin domains involved in DNA double-strand breaks in vivo

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

Roles of BRCA1 and BRCA2 in homologous recombination, DNA replication fidelity and the cellular response to ionizing radiation

Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

Upstream and downstream of mTOR

A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells

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214-224

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scholarly article

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10.1667/RR2323.1

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2

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175

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2010-10-26T00:00:00Z

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21268715

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4412148

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