Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degeneration. - Wikidata - wikimedia - TriplyDB

Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degeneration.

Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degeneration.

http://www.wikidata.org/entity/Q35546888

about

Inflammation and its role in age-related macular degeneration The proteomics of drusen The Project MACULA Retinal Pigment Epithelium Grading System for Histology and Optical Coherence Tomography in Age-Related Macular Degeneration A novel antibody against human properdin inhibits the alternative complement system and specifically detects properdin from blood samples.Smoke exposure causes endoplasmic reticulum stress and lipid accumulation in retinal pigment epithelium through oxidative stress and complement activation.Cholesterol in the retina: the best is yet to come.Mutant Fibulin-3 Causes Proteoglycan Accumulation and Impaired Diffusion Across Bruch's Membrane.Complement-Mediated Regulation of Apolipoprotein E in Cultured Human RPE Cells.Complement system in pathogenesis of AMD: dual player in degeneration and protection of retinal tissue.Bioactive lysophospholipids generated by hepatic lipase degradation of lipoproteins lead to complement activation via the classical pathway Plasma proteome analysis on cynomolgus monkey (Macaca fascicularis) pedigrees with early onset drusen formation.The membrane attack complex in aging human choriocapillaris: relationship to macular degeneration and choroidal thinning.Oxidative stress sensitizes retinal pigmented epithelial (RPE) cells to complement-mediated injury in a natural antibody-, lectin pathway-, and phospholipid epitope-dependent manner.Subcellular distribution and activity of mechanistic target of rapamycin in aged retinal pigment epithelium.New compstatin peptides containing N-terminal extensions and non-natural amino acids exhibit potent complement inhibition and improved solubility characteristics Identification of hydroxyapatite spherules provides new insight into subretinal pigment epithelial deposit formation in the aging eye Apolipoprotein E promotes subretinal mononuclear phagocyte survival and chronic inflammation in age-related macular degeneration Complement activation and choriocapillaris loss in early AMD: implications for pathophysiology and therapy.Inhibition of APE1/Ref-1 redox activity rescues human retinal pigment epithelial cells from oxidative stress and reduces choroidal neovascularization.7-Ketocholesterol increases retinal microglial migration, activation, and angiogenicity: a potential pathogenic mechanism underlying age-related macular degeneration Cellular models and therapies for age-related macular degeneration.Complementing apolipoprotein secretion by cultured retinal pigment epithelium.A local complement response by RPE causes early-stage macular degeneration.Complement Factor H Binds to Human Serum Apolipoprotein E and Mediates Complement Regulation on High Density Lipoprotein Particles.A2E accumulation influences retinal microglial activation and complement regulation Chronic oxidative stress upregulates Drusen-related protein expression in adult human RPE stem cell-derived RPE cells: a novel culture model for dry AMD.Regression of Some High-risk Features of Age-related Macular Degeneration (AMD) in Patients Receiving Intensive Statin Treatment.Aryl hydrocarbon receptor deficiency causes dysregulated cellular matrix metabolism and age-related macular degeneration-like pathology.Aging is not a disease: distinguishing age-related macular degeneration from aging.Common coding variants in the HLA-DQB1 region confer susceptibility to age-related macular degeneration.Peptide redesign for inhibition of the complement system: Targeting age-related macular degeneration.SIRT1 negatively regulates amyloid-beta-induced inflammation via the NF-κB pathway.Mouse genetics and proteomic analyses demonstrate a critical role for complement in a model of DHRD/ML, an inherited macular degeneration.Dry age-related macular degeneration: mechanisms, therapeutic targets, and imaging.Subretinal drusenoid deposits in non-neovascular age-related macular degeneration: morphology, prevalence, topography, and biogenesis model.Immunology of age-related macular degeneration Subretinal Pigment Epithelial Deposition of Drusen Components Including Hydroxyapatite in a Primary Cell Culture Model.Bisretinoid-mediated complement activation on retinal pigment epithelial cells is dependent on complement factor H haplotype.Clusterin and complement activation in exfoliation glaucoma.Matrix metalloproteinase activity creates pro-angiogenic environment in primary human retinal pigment epithelial cells exposed to complement.

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P2860

Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degeneration.

http://www.wikidata.org/entity/Q35546888

description

2011 nî lūn-bûn

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2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Cell culture model that mimics ...... -related macular degeneration.

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Cell culture model that mimics ...... -related macular degeneration.

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Cell culture model that mimics ...... -related macular degeneration.

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Proceedings of the National Academy of Sciences of the United States of America

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Cell culture model that mimics ...... -related macular degeneration.

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P2093

Aimee M Walker

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Carolyn M Radeke

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Christine N Spencer

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Christopher D Banna

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David L Forest

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Dean Bok

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Don H Anderson

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Jane Hu

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Lincoln V Johnson

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Marlene S Tsie

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P2860

C1q binds phosphatidylserine and likely acts as a multiligand-bridging molecule in apoptotic cell recognition

An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration

Local cellular sources of apolipoprotein E in the human retina and retinal pigmented epithelium: implications for the process of drusen formation.

A cell culture medium that supports the differentiation of human retinal pigment epithelium into functionally polarized monolayers.

Characterization of beta amyloid assemblies in drusen: the deposits associated with aging and age-related macular degeneration.

Accumulation of cholesterol with age in human Bruch's membrane.

Structure and activation of the C1 complex of complement: unraveling the puzzle.

The spectrum of complement alternative pathway-mediated diseases.

Abundant lipid and protein components of drusen

Apolipoprotein B-containing lipoproteins in retinal aging and age-related macular degeneration.

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18277-18282

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10.1073/PNAS.1109703108

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21969589

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