CD47-signal regulatory protein-α (SIRPα) interactions form a barrier for antibody-mediated tumor cell destruction. - Wikidata - wikimedia - TriplyDB

CD47-signal regulatory protein-α (SIRPα) interactions form a barrier for antibody-mediated tumor cell destruction.

CD47-signal regulatory protein-α (SIRPα) interactions form a barrier for antibody-mediated tumor cell destruction.

http://www.wikidata.org/entity/Q35546950

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CD47: A Cell Surface Glycoprotein Which Regulates Multiple Functions of Hematopoietic Cells in Health and Disease The CD47-SIRPα pathway in cancer immune evasion and potential therapeutic implications Engineered SIRPα variants as immunotherapeutic adjuvants to anticancer antibodies.Therapeutic opportunities for targeting the ubiquitous cell surface receptor CD47 Thrombospondin-1 signaling through CD47 inhibits self-renewal by regulating c-Myc and other stem cell transcription factors Interplay between Cellular and Molecular Inflammatory Mediators in Lung Cancer Signalling pathways in UHRF1-dependent regulation of tumor suppressor genes in cancer Immunogenic versus tolerogenic phagocytosis during anticancer therapy: mechanisms and clinical translation Dissection of agonistic and blocking effects of CD200 receptor antibodies CD47 agonist peptides induce programmed cell death in refractory chronic lymphocytic leukemia B cells via PLCγ1 activation: evidence from mice and humans Plasmodium falciparum malaria and invasive bacterial co-infection in young African children: the dysfunctional spleen hypothesis.Silencing of CD47 and SIRPα by Polypurine reverse Hoogsteen hairpins to promote MCF-7 breast cancer cells death by PMA-differentiated THP-1 cells Engagement of SIRPα inhibits growth and induces programmed cell death in acute myeloid leukemia cells.CD47 in the tumor microenvironment limits cooperation between antitumor T-cell immunity and radiotherapy Therapeutic targeting of the thrombospondin-1 receptor CD47 to treat liver cancer."Velcro" engineering of high affinity CD47 ectodomain as signal regulatory protein α (SIRPα) antagonists that enhance antibody-dependent cellular phagocytosis CD47 Promotes Protective Innate and Adaptive Immunity in a Mouse Model of Disseminated Candidiasis.Pre-Clinical Development of a Humanized Anti-CD47 Antibody with Anti-Cancer Therapeutic Potential.Anti-CD47 Treatment Stimulates Phagocytosis of Glioblastoma by M1 and M2 Polarized Macrophages and Promotes M1 Polarized Macrophages In Vivo.CD47 is an adverse prognostic factor and a therapeutic target in gastric cancer.Molecular Pathways: Activating T Cells after Cancer Cell Phagocytosis from Blockade of CD47 "Don't Eat Me" Signals.Macrophages are critical effectors of antibody therapies for cancer Antibody-mediated phagocytosis contributes to the anti-tumor activity of the therapeutic antibody daratumumab in lymphoma and multiple myeloma A bispecific antibody targeting CD47 and CD20 selectively binds and eliminates dual antigen expressing lymphoma cells Original insights on thrombospondin-1-related antireceptor strategies in cancer.Disruption of SIRPα signaling in macrophages eliminates human acute myeloid leukemia stem cells in xenografts.Humanized Affinity-matured Monoclonal Antibody 8H9 Has Potent Antitumor Activity and Binds to FG Loop of Tumor Antigen B7-H3.Durable antitumor responses to CD47 blockade require adaptive immune stimulation.A function-blocking CD47 antibody suppresses stem cell and EGF signaling in triple-negative breast cancer.CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer.CD47 Promotes Tumor Invasion and Metastasis in Non-small Cell Lung Cancer.Autophagy proteins regulate cell engulfment mechanisms that participate in cancer.Cd47-Sirpα interaction and IL-10 constrain inflammation-induced macrophage phagocytosis of healthy self-cells.Myeloid Cell Origins, Differentiation, and Clinical Implications.Anti-SIRPα antibodies as a potential new tool for cancer immunotherapy.Targeting CD47: the achievements and concerns of current studies on cancer immunotherapy.Anti-leukemic activity and tolerability of anti-human CD47 monoclonal antibodies.Nanoparticles-mediated drug delivery approaches for cancer targeting: a review.Engineering antiphagocytic biomimetic drug carriers.The CD47-SIRPα signalling system: its physiological roles and therapeutic application.

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CD47-signal regulatory protein-α (SIRPα) interactions form a barrier for antibody-mediated tumor cell destruction.

http://www.wikidata.org/entity/Q35546950

description

2011 nî lūn-bûn

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2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2011 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

CD47-signal regulatory protein ...... diated tumor cell destruction.

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CD47-signal regulatory protein ...... diated tumor cell destruction.

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type

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CD47-signal regulatory protein ...... diated tumor cell destruction.

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CD47-signal regulatory protein ...... diated tumor cell destruction.

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CD47-signal regulatory protein ...... diated tumor cell destruction.

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CD47-signal regulatory protein ...... diated tumor cell destruction.

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PNAS.1106550108

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CD47-signal regulatory protein ...... diated tumor cell destruction.

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Andrea van Elsas

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Daniel Birnbaum

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Ellen M van Beek

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Francois Bertucci

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Georg Kraal

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Hans Van der Maaden

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Karin Schornagel

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Marielle A Otten

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Marjolein Van Egmond

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Michel Van Houdt

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P2860

A family of proteins that inhibit signalling through tyrosine kinase receptors

Identification of major binding proteins and substrates for the SH2-containing protein tyrosine phosphatase SHP-1 in macrophages

A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion

Structure of Signal-regulatory Protein : A LINK TO ANTIGEN RECEPTOR EVOLUTION

Role of CD47 as a marker of self on red blood cells

Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets

Bidirectional negative regulation of human T and dendritic cells by CD47 and its cognate receptor signal-regulator protein-alpha: down-regulation of IL-12 responsiveness and inhibition of dendritic cell activation

The SIRP family of receptors and immune regulation

Signal regulatory proteins in the immune system

Integrin-associated protein is a ligand for the P84 neural adhesion molecule

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108

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51760192

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