The methylerythritol phosphate pathway and its significance as a novel drug target.
about
Characterization of the Mycobacterium tuberculosis 4-diphosphocytidyl-2-C-methyl-D-erythritol synthase: potential for drug developmentBiosynthesis of isoprenoids in plants: Structure of the 2C-methyl-d-erithrytol 2,4-cyclodiphosphate synthase fromArabidopsis thaliana. Comparison with the bacterial enzymesStructures of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase/Lipophilic Phosphonate ComplexesInhibition of 1-Deoxy- d -Xylulose-5-Phosphate Reductoisomerase by Lipophilic Phosphonates: SAR, QSAR, and Crystallographic StudiesExpression and characterization of soluble 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase from bacterial pathogens.Synthetic Routes to Methylerythritol Phosphate Pathway Intermediates and Downstream Isoprenoids.N-O chemistry for antibiotics: discovery of N-alkyl-N-(pyridin-2-yl)hydroxylamine scaffolds as selective antibacterial agents using nitroso Diels-Alder and ene chemistry.Identification of novel small molecule inhibitors of 4-diphosphocytidyl-2-C-methyl-D-erythritol (CDP-ME) kinase of Gram-negative bacteria.Biosynthesis of Menaquinone (Vitamin K2) and Ubiquinone (Coenzyme Q)Semi-automated curation of metabolic models via flux balance analysis: a case study with Mycoplasma gallisepticumCrystallization and preliminary X-ray analysis of 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (IspE) from Mycobacterium tuberculosis.Sub-inhibitory fosmidomycin exposures elicits oxidative stress in Salmonella enterica serovar Typhimurium LT2.Antibacterial and antitubercular activity of fosmidomycin, FR900098, and their lipophilic analogs.A whole-cell phenotypic screening platform for identifying methylerythritol phosphate pathway-selective inhibitors as novel antibacterial agents.Thermodynamic Investigation of Inhibitor Binding to 1-Deoxy-D-Xylulose-5-Phosphate ReductoisomeraseDesign of Potential Bisubstrate Inhibitors against Mycobacterium tuberculosis (Mtb) 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase (Dxr)-Evidence of a Novel Binding Mode.DXP synthase-catalyzed C-N bond formation: nitroso substrate specificity studies guide selective inhibitor design.Molecular Mechanism of Action of Antimalarial Benzoisothiazolones: Species-Selective Inhibitors of the Plasmodium spp. MEP Pathway enzyme, IspDViable screening targets related to the bacterial cell wall.Revealing substrate promiscuity of 1-deoxy-D-xylulose 5-phosphate synthase.Optimization of the IPP Precursor Supply for the Production of Lycopene, Decaprenoxanthin and Astaxanthin by Corynebacterium glutamicum.
P2860
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P2860
The methylerythritol phosphate pathway and its significance as a novel drug target.
description
2003 nî lūn-bûn
@nan
2003 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
The methylerythritol phosphate pathway and its significance as a novel drug target.
@ast
The methylerythritol phosphate pathway and its significance as a novel drug target.
@en
type
label
The methylerythritol phosphate pathway and its significance as a novel drug target.
@ast
The methylerythritol phosphate pathway and its significance as a novel drug target.
@en
prefLabel
The methylerythritol phosphate pathway and its significance as a novel drug target.
@ast
The methylerythritol phosphate pathway and its significance as a novel drug target.
@en
P356
P1476
The methylerythritol phosphate pathway and its significance as a novel drug target.
@en
P2093
P304
P356
10.2174/1389201033489784
P577
2003-08-01T00:00:00Z