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Evolutionary Ecology of Prokaryotic Immune MechanismsThe Bacteriophage Carrier State of Campylobacter jejuni Features Changes in Host Non-coding RNAs and the Acquisition of New Host-derived CRISPR Spacer SequencesGenome Engineering with TALE and CRISPR Systems in NeuroscienceA Small RNA-Based Immune System Defends Germ Cells against Mobile Genetic ElementsDiversity of CRISPR-Cas immune systems and molecular machinesA new age in functional genomics using CRISPR/Cas9 in arrayed library screeningEnabling functional genomics with genome engineeringCurrent and future prospects for CRISPR-based tools in bacteriaUse of designer nucleases for targeted gene and genome editing in plantsMechanism of CRISPR-RNA guided recognition of DNA targets in Escherichia coli.Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavageExploiting the CRISPR/Cas9 PAM Constraint for Single-Nucleotide Resolution InterventionsIdentification of high-efficiency 3'GG gRNA motifs in indexed FASTA files with ngg2Striking Plasticity of CRISPR-Cas9 and Key Role of Non-target DNA, as Revealed by Molecular Simulations.Target DNA recognition and cleavage by a reconstituted Type I-G CRISPR-Cas immune effector complex.Structural and dynamic insights into the role of conformational switching in the nuclease activity of the Xanthomonas albilineans Cas2 in CRISPR-mediated adaptive immunity.Bacterial CRISPR: accomplishments and prospects.Applications of CRISPR technologies in research and beyond.Analysis of the type II-A CRISPR-Cas system of Streptococcus agalactiae reveals distinctive features according to genetic lineages.Structural requirements for protein-catalyzed annealing of U4 and U6 RNAs during di-snRNP assembly.A CRISPR Path to Engineering New Genetic Mouse Models for Cardiovascular ResearchThe dawn of active genetics.Multiple nucleic acid cleavage modes in divergent type III CRISPR systems.Probing the structural dynamics of the CRISPR-Cas9 RNA-guided DNA-cleavage system by coarse-grained modeling.Imaging Specific Genomic DNA in Living CellsRepurposing CRISPR System for Transcriptional Activation.Guide-bound structures of an RNA-targeting A-cleaving CRISPR-Cas13a enzyme.Alternate binding modes of anti-CRISPR viral suppressors AcrF1/2 to Csy surveillance complex revealed by cryo-EM structures.Bioinformatics comparisons of RNA-binding proteins of pathogenic and non-pathogenic Escherichia coli strains reveal novel virulence factors.Engineering and Application of Zinc Finger Proteins and TALEs for Biomedical Research.Programmable type III-A CRISPR-Cas DNA targeting modulesRegulatory and Scientific Advancements in Gene Therapy: State-of-the-Art of Clinical Applications and of the Supporting European Regulatory Framework.Nucleic Acid-Dependent Conformational Changes in CRISPR-Cas9 Revealed by Site-Directed Spin Labeling.Second-Shell Basic Residues Expand the Two-Metal-Ion Architecture of DNA and RNA Processing Enzymes.The initiation, propagation and dynamics of CRISPR-SpyCas9 R-loop complex.Role of free DNA ends and protospacer adjacent motifs for CRISPR DNA uptake in Pyrococcus furiosus.The Impact of DNA Topology and Guide Length on Target Selection by a Cytosine-Specific Cas9.CRISPR RNA and anti-CRISPR protein binding to the Xanthomonas albilineans Csy1-Csy2 heterodimer in the type I-F CRISPR-Cas system.Structure Basis for Directional R-loop Formation and Substrate Handover Mechanisms in Type I CRISPR-Cas System.Genome editing: The domestication of Cas9.
P2860
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P2860
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
The structural biology of CRISPR-Cas systems
@ast
The structural biology of CRISPR-Cas systems
@en
type
label
The structural biology of CRISPR-Cas systems
@ast
The structural biology of CRISPR-Cas systems
@en
prefLabel
The structural biology of CRISPR-Cas systems
@ast
The structural biology of CRISPR-Cas systems
@en
P2860
P1476
The structural biology of CRISPR-Cas systems
@en
P2093
Fuguo Jiang
P2860
P304
P356
10.1016/J.SBI.2015.02.002
P577
2015-02-24T00:00:00Z