Transcript level alterations reflect gene dosage effects across multiple tissues in a mouse model of down syndrome - Wikidata - wikimedia - TriplyDB

Transcript level alterations reflect gene dosage effects across multiple tissues in a mouse model of down syndrome

Transcript level alterations reflect gene dosage effects across multiple tissues in a mouse model of down syndrome

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Primary and secondary transcriptional effects in the developing human Down syndrome brain and heart Gene-dosage effects in Down syndrome and trisomic mouse models Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins Concise review: new paradigms for Down syndrome research using induced pluripotent stem cells: tackling complex human genetic disease Submicroscopic deletion in patients with Williams-Beuren syndrome influences expression levels of the nonhemizygous flanking genes Chromosomal instability and cancer: a complex relationship with therapeutic potential Aneuploidy: cells losing their balance Cross-species hybridisation of human and bovine orthologous genes on high density cDNA microarrays Hard-Wired Control of Bacterial Processes by Chromosomal Gene Location Mouse models of Down syndrome as a tool to unravel the causes of mental disabilities Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome Chromosome 21 and down syndrome: from genomics to pathophysiology Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down syndrome: activation of β1-adrenergic receptor by xamoterol as a potential cognitive enhancer.The use of mouse models to understand and improve cognitive deficits in Down syndrome.A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions.Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice.Expression evolution facilitated the convergent neofunctionalization of a sodium channel gene.Validation of microarray data in human lymphoblasts shows a role of the ubiquitin-proteasome system and NF-kB in the pathogenesis of Down syndrome.PCP4 (PEP19) overexpression induces premature neuronal differentiation associated with Ca(2+) /calmodulin-dependent kinase II-δ activation in mouse models of Down syndrome.Genetic dissection of the Down syndrome critical region.Discovery of novel serum biomarkers for prenatal Down syndrome screening by integrative data mining.Trisomy for the Down syndrome 'critical region' is necessary but not sufficient for brain phenotypes of trisomic mice.Cell type-specific over-expression of chromosome 21 genes in fibroblasts and fetal hearts with trisomy 21.Understanding the basis for Down syndrome phenotypes.Altered expression of mitochondrial and extracellular matrix genes in the heart of human fetuses with chromosome 21 trisomy Profiling expression changes caused by a segmental aneuploid in maize.Differential expression of genes mapping to recurrently abnormal chromosomal regions characterize neuroblastic tumours with distinct ploidy status A mouse embryonic stem cell bank for inducible overexpression of human chromosome 21 genes.Detection of Copy Number Alterations Using Single Cell Sequencing Meiotic behavior of aneuploid chromatin in mouse models of Down syndrome.Gene expression profiling in a mouse model identifies fetal liver- and placenta-derived potential biomarkers for Down Syndrome screening.Meta-analysis of heterogeneous Down Syndrome data reveals consistent genome-wide dosage effects related to neurological processes Ohnologs in the human genome are dosage balanced and frequently associated with disease.Segmental trisomy of chromosome 17: a mouse model of human aneuploidy syndromes Functional transcriptome analysis of the postnatal brain of the Ts1Cje mouse model for Down syndrome reveals global disruption of interferon-related molecular networks Transcriptome-wide survey of mouse CNS-derived cells reveals monoallelic expression within novel gene families.Single cell sequencing reveals low levels of aneuploidy across mammalian tissues.Abnormal microRNA expression in Ts65Dn hippocampus and whole blood: contributions to Down syndrome phenotypes.The App-Runx1 region is critical for birth defects and electrocardiographic dysfunctions observed in a Down syndrome mouse model.No Evidence for Mutations that Deregulate GARS-AIRS-GART Protein Levels in Children with Down Syndrome

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P2860

Astrocytosis and axonal proliferation in the hippocampus of S100b transgenic mice.

DSCAM: a novel member of the immunoglobulin superfamily maps in a Down syndrome region and is involved in the development of the nervous system

Identification of tissue-specific microRNAs from mouse

Global up-regulation of chromosome 21 gene expression in the developing Down syndrome brain

Purification and properties of cystathionine beta-synthase from human liver. Evidence for identical subunits

Mouse Col18a1 is expressed in a tissue-specific manner as three alternative variants and is localized in basement membrane zones

Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection

Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity

A gene expression map of human chromosome 21 orthologues in the mouse.

The mouse brain transcriptome by SAGE: differences in gene expression between P30 brains of the partial trisomy 16 mouse model of Down syndrome (Ts65Dn) and normals

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