The IL-15/IL-15Ralpha on cell surfaces enables sustained IL-15 activity and contributes to the long survival of CD8 memory T cells
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Antibody-mediated blockade of IL-15 reverses the autoimmune intestinal damage in transgenic mice that overexpress IL-15 in enterocytesProliferation-linked apoptosis of adoptively transferred T cells after IL-15 administration in macaquesCrystal Structure of the interleukin-15.interleukin-15 receptor alpha complex: insights into trans and cis presentationRole of secreted conjunctival mucosal cytokine and chemokine proteins in different stages of trachomatous diseaseSelected microRNAs define cell fate determination of murine central memory CD8 T cells.Plasmid-encoded interleukin-15 receptor alpha enhances specific immune responses induced by a DNA vaccine in vivo.Vaccines against human carcinomas: strategies to improve antitumor immune responses.Rapid release of cytoplasmic IL-15 from tumor-associated macrophages is an initial and critical event in IL-12-initiated tumor regression.Evidence of STAT5-dependent and -independent routes to CD8 memory formation and a preferential role for IL-7 over IL-15 in STAT5 activationMonocytes differentiated with IL-15 support Th17 and Th1 responses to wheat gliadin: implications for celiac disease.Expression of IL-15RA or an IL-15/IL-15RA fusion on CD8+ T cells modifies adoptively transferred T-cell function in cisA role for IL-15 in the migration of effector CD8 T cells to the lung airways following influenza infection.IL-15 complexes induce NK- and T-cell responses independent of type I IFN signaling during rhinovirus infectionDevelopment of an IL-15-autocrine CD8 T-cell leukemia in IL-15-transgenic mice requires the cis expression of IL-15Rα.Dendritic cell-derived interleukin-15 is crucial for therapeutic cancer vaccine potency.Mechanistic model of natural killer cell proliferative response to IL-15 receptor stimulationSafety (toxicity), pharmacokinetics, immunogenicity, and impact on elements of the normal immune system of recombinant human IL-15 in rhesus macaques.Determinants of successful CD8+ T-cell adoptive immunotherapy for large established tumors in mice.TLR-9 and IL-15 Synergy Promotes the In Vitro Clonal Expansion of Chronic Lymphocytic Leukemia B Cells.Adjuvants and myeloid-derived suppressor cells: enemies or allies in therapeutic cancer vaccination.Expression of interleukin-15 and interleukin-15Rα in monocytes of HIV type 1-infected patients with different courses of disease progression.The differential production of cytokines by human Langerhans cells and dermal CD14(+) DCs controls CTL primingCirculating IL-15 exists as heterodimeric complex with soluble IL-15Rα in human and mouse serum.Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primatesNK Cell Proliferation Induced by IL-15 Transpresentation Is Negatively Regulated by Inhibitory Receptors.Poxviral vectors for cancer immunotherapyIL-15Ralpha chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation.Regulatory and conventional CD4+ T cells show differential effects correlating with PD-1 and B7-H1 expression after immunotherapyIL-15 in tumor microenvironment causes rejection of large established tumors by T cells in a noncognate T cell receptor-dependent mannerConfiguration-dependent Presentation of Multivalent IL-15:IL-15Rα Enhances the Antigen-specific T Cell Response and Anti-tumor ImmunitySequential priming with simian immunodeficiency virus (SIV) DNA vaccines, with or without encoded cytokines, and a replicating adenovirus-SIV recombinant followed by protein boosting does not control a pathogenic SIVmac251 mucosal challengeInterleukin-15 and interleukin-15R alpha SNPs and associations with muscle, bone, and predictors of the metabolic syndromeOvarian hormone level alterations during rat post-reproductive life-span influence CD8 + T-cell homeostasis.T cell homeostasis.Exogenous IL-15 in combination with IL-15R alpha rescues natural killer cells from apoptosis induced by chronic alcohol consumption.Targeting poly(I:C) to the TLR3-independent pathway boosts effector CD8 T cell differentiation through IFN-alpha/betaInterleukin-15 combined with an anti-CD40 antibody provides enhanced therapeutic efficacy for murine models of colon cancerIL-15 expands unconventional CD8alphaalphaNK1.1+ T cells but not Valpha14Jalpha18+ NKT cellsIL-15 produced and trans-presented by DCs underlies homeostatic competition between CD8 and {gamma}{delta} T cells in vivoEffect of interleukin-15 on the course of myocarditis in Coxsackievirus B3-infected BALB/c mice.
P2860
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P2860
The IL-15/IL-15Ralpha on cell surfaces enables sustained IL-15 activity and contributes to the long survival of CD8 memory T cells
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
The IL-15/IL-15Ralpha on cell ...... survival of CD8 memory T cells
@ast
The IL-15/IL-15Ralpha on cell ...... survival of CD8 memory T cells
@en
type
label
The IL-15/IL-15Ralpha on cell ...... survival of CD8 memory T cells
@ast
The IL-15/IL-15Ralpha on cell ...... survival of CD8 memory T cells
@en
prefLabel
The IL-15/IL-15Ralpha on cell ...... survival of CD8 memory T cells
@ast
The IL-15/IL-15Ralpha on cell ...... survival of CD8 memory T cells
@en
P2093
P2860
P356
P1476
The IL-15/IL-15Ralpha on cell ...... survival of CD8 memory T cells
@en
P2093
Hiral J Patel
Noriko Sato
Thomas A Waldmann
Yutaka Tagaya
P2860
P304
P356
10.1073/PNAS.0610115104
P407
P577
2007-01-03T00:00:00Z