A transmembrane form of the prion protein contains an uncleaved signal peptide and is retained in the endoplasmic Reticulum.
about
Proteasomes and ubiquitin are involved in the turnover of the wild-type prion proteinEarly Vertebrate Evolution of the Host Restriction Factor TetherinCounteraction of the multifunctional restriction factor tetherinAlternative translation initiation generates cytoplasmic sheep prion protein.Antimicrobial activity of human prion protein is mediated by its N-terminal region.Perturbation of endoplasmic reticulum homeostasis facilitates prion replication.Prion protein misfolding affects calcium homeostasis and sensitizes cells to endoplasmic reticulum stress.Wild-type PrP and a mutant associated with prion disease are subject to retrograde transport and proteasome degradation.Neurotoxic mutants of the prion protein induce spontaneous ionic currents in cultured cellsCotranslational partitioning of nascent prion protein into multiple populations at the translocation channel.Topogenesis of membrane proteins: determinants and dynamics.Compartment-restricted biotinylation reveals novel features of prion protein metabolism in vivo.Cell-specific metabolism and pathogenesis of transmembrane prion protein.An uncleaved signal peptide directs the Malus xiaojinensis iron transporter protein Mx IRT1 into the ER for the PM secretory pathway.Existence of an operative pathway from the endoplasmic reticulum to the immature poxvirus membrane.Proteasomal dysfunction and endoplasmic reticulum stress enhance trafficking of prion protein aggregates through the secretory pathway and increase accumulation of pathologic prion proteinPrion diseases: from molecular biology to intervention strategies.Doppel induces degeneration of cerebellar Purkinje cells independently of BaxPathogenesis of prion diseases.Prion protein glycosylation.Versatility of the endoplasmic reticulum protein folding factory.Prion neurotoxicity: insights from prion protein mutantsNeurotoxic species in prion disease: a role for PrP isoforms?Cytosolic prion protein is the predominant anti-Bax prion protein form: exclusion of transmembrane and secreted prion protein forms in the anti-Bax functionPolar substitutions in helix 3 of the prion protein produce transmembrane isoforms that disturb vesicle trafficking.Intact signal peptide of CD18, the beta-subunit of beta2-integrins, renders ruminants susceptible to Mannheimia haemolytica leukotoxin.Prion protein-detergent micelle interactions studied by NMR in solution.Protection from cytosolic prion protein toxicity by modulation of protein translocation.Physiological Functions of the Cellular Prion Protein.Tetherin and its viral antagonists.The Protein-disulfide Isomerase ERp57 Regulates the Steady-state Levels of the Prion Protein.Failure of prion protein oxidative folding guides the formation of toxic transmembrane forms.Subclinical prion disease induced by oral inoculation.Prion protein region 23-32 interacts with tubulin and inhibits microtubule assembly.A deleted prion protein that is neurotoxic in vivo is localized normally in cultured cells.PrPC is sorted to the basolateral membrane of epithelial cells independently of its association with rafts.Mutant prion proteins are partially retained in the endoplasmic reticulum.Neonatal lethality in transgenic mice expressing prion protein with a deletion of residues 105-125.Cell surface accumulation of a truncated transmembrane prion protein in Gerstmann-Straussler-Scheinker disease P102L.Stimulation of PrP(C) retrograde transport toward the endoplasmic reticulum increases accumulation of PrP(Sc) in prion-infected cells.
P2860
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P2860
A transmembrane form of the prion protein contains an uncleaved signal peptide and is retained in the endoplasmic Reticulum.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
A transmembrane form of the pr ...... in the endoplasmic Reticulum.
@ast
A transmembrane form of the pr ...... in the endoplasmic Reticulum.
@en
type
label
A transmembrane form of the pr ...... in the endoplasmic Reticulum.
@ast
A transmembrane form of the pr ...... in the endoplasmic Reticulum.
@en
prefLabel
A transmembrane form of the pr ...... in the endoplasmic Reticulum.
@ast
A transmembrane form of the pr ...... in the endoplasmic Reticulum.
@en
P2860
P921
P356
P1476
A transmembrane form of the pr ...... d in the endoplasmic Reticulum
@en
P2093
B Drisaldi
R S Stewart
P2860
P304
P356
10.1091/MBC.12.4.881
P577
2001-04-01T00:00:00Z