Increase in dNTP pool size during the DNA damage response plays a key role in spontaneous and induced-mutagenesis in Escherichia coli
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Implications of genetic heterogeneity in cancerRole of Arginine 293 and Glutamine 288 in Communication between Catalytic and Allosteric Sites in Yeast Ribonucleotide ReductaseHug1 is an intrinsically disordered protein that inhibits ribonucleotide reductase activity by directly binding Rnr2 subunit.Yeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrationsA hybrid stochastic model of folate-mediated one-carbon metabolism: Effect of the common C677T MTHFR variant on de novo thymidylate biosynthesisPolymerase exchange on single DNA molecules reveals processivity clamp control of translesion synthesis.Differential control of dNTP biosynthesis and genome integrity maintenance by the dUTPase superfamily enzymes.Loss of the thioredoxin reductase Trr1 suppresses the genomic instability of peroxiredoxin tsa1 mutantsRedesigning human 2'-deoxycytidine kinase enantioselectivity for L-nucleoside analogues as reporters in positron emission tomographyStructural basis of cellular dNTP regulation by SAMHD1.Translesion DNA synthesis and mutagenesis in prokaryotes.Replisome-mediated translesion synthesis and leading strand template lesion skipping are competing bypass mechanismsSuppression of the E. coli SOS response by dNTP pool changes.Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelitydNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ε variants.Pools and Pols: Mechanism of a mutator phenotype.DNA replication fidelity in Escherichia coli: a multi-DNA polymerase affair.Effects of a mitochondrial mutator mutation in yeast POS5 NADH kinase on mitochondrial nucleotides.Development of potent in vivo mutagenesis plasmids with broad mutational spectra.Mutational consequences of dNTP pool imbalances in E. coli.Extreme dNTP pool changes and hypermutability in dcd ndk strains.Analysis of LexA binding sites and transcriptomics in response to genotoxic stress in Leptospira interrogans.Mutations for Worse or Better: Low-Fidelity DNA Synthesis by SOS DNA Polymerase V Is a Tightly Regulated Double-Edged SwordHeterozygous colon cancer-associated mutations of SAMHD1 have functional significanceTranscriptome Analysis of Escherichia coli during dGTP Starvation.The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells.Multiple strategies for translesion synthesis in bacteriaRisks at the DNA Replication Fork: Effects upon Carcinogenesis and Tumor HeterogeneityChronology in lesion tolerance gives priority to genetic variability.The prototypic class Ia ribonucleotide reductase from Escherichia coli: still surprising after all these years.Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies.Deoxyribonucleotides as genetic and metabolic regulatorsDeoxyribonucleotide metabolism, mutagenesis and cancer.Targeting nuclear thymidylate biosynthesis.A Critical Balance: dNTPs and the Maintenance of Genome StabilityThe mutagenic footprint of low-fidelity Pol I ColE1 plasmid replication in E. coli reveals an extensive interplay between Pol I and Pol III.Deoxycytidine deaminase-deficient Escherichia coli strains display acute sensitivity to cytidine, adenosine, and guanosine and increased sensitivity to a range of antibiotics, including vancomycin.Countermeasures to survive excessive chromosome replication in Escherichia coli.Spontaneous mutation rate is a plastic trait associated with population density across domains of life.Mutagen Synergy: Hypermutability Generated by Specific Pairs of Base Analogs.
P2860
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P2860
Increase in dNTP pool size during the DNA damage response plays a key role in spontaneous and induced-mutagenesis in Escherichia coli
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Increase in dNTP pool size dur ...... utagenesis in Escherichia coli
@ast
Increase in dNTP pool size dur ...... utagenesis in Escherichia coli
@en
type
label
Increase in dNTP pool size dur ...... utagenesis in Escherichia coli
@ast
Increase in dNTP pool size dur ...... utagenesis in Escherichia coli
@en
prefLabel
Increase in dNTP pool size dur ...... utagenesis in Escherichia coli
@ast
Increase in dNTP pool size dur ...... utagenesis in Escherichia coli
@en
P2093
P2860
P356
P1476
Increase in dNTP pool size dur ...... utagenesis in Escherichia coli
@en
P2093
Rita Napolitano
Robert P Fuchs
Stéphane Coulon
Walter Rocha
P2860
P304
19311-19316
P356
10.1073/PNAS.1113664108
P407
P577
2011-11-14T00:00:00Z