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Predicting Drug Extraction in the Human Gut Wall: Assessing Contributions from Drug Metabolizing Enzymes and Transporter Proteins using Preclinical ModelsInteractions between CYP3A4 and Dietary PolyphenolsMultiple NSAID-induced hits injure the small intestine: underlying mechanisms and novel strategiesAn update on the role of intestinal cytochrome P450 enzymes in drug dispositionOrgan data from the developing Göttingen minipig: first steps towards a juvenile PBPK model.Gene expression of transporters and phase I/II metabolic enzymes in murine small intestine during fasting.PPARalpha-mediated effects of dietary lipids on intestinal barrier gene expression.Dietary regulation of Keap1/Nrf2/ARE pathway: focus on plant-derived compounds and trace minerals.Early metabolism evaluation making traditional Chinese medicine effective and safe therapeutics.Bioavailability and risk assessment of orally ingested polycyclic aromatic hydrocarbons.Proteomic analysis of lipid droplets from Caco-2/TC7 enterocytes identifies novel modulators of lipid secretionFunctional interactions between P-glycoprotein and CYP3A in drug metabolism.Prediction of human pharmacokinetics--gut-wall metabolism.Role of intestinal cytochrome P450 (P450) in modulating the bioavailability of oral lovastatin: insights from studies on the intestinal epithelium-specific P450 reductase knockout mouse.Dietary phytochemicals regulate whole-body CYP1A1 expression through an arylhydrocarbon receptor nuclear translocator-dependent system in gut.Nonlinear transcriptomic response to dietary fat intake in the small intestine of C57BL/6J miceIntegrative Network-based Analysis of Colonic Detoxification Gene Expression in Ulcerative Colitis According to Smoking Status.The human intestinal cytochrome P450 "pie".Adipose triglyceride lipase is a TG hydrolase of the small intestine and regulates intestinal PPARα signalingDietary regulation of mouse intestinal P450 expression and drug metabolismThe influence of circadian rhythms on the kinetics of drugs in humans.An intestinal epithelium-specific cytochrome P450 (P450) reductase-knockout mouse model: direct evidence for a role of intestinal p450s in first-pass clearance of oral nifedipine.Pharmacokinetics of oltipraz in diabetic rats with liver cirrhosis.The effect of oral lipids and circulating lipoproteins on the metabolism of drugs.Effects of ticlopidine on pharmacokinetics of losartan and its main metabolite EXP-3174 in rats.Intestinal gene expression in pigs: effects of reduced feed intake during weaning and potential impact of dietary components.In vitro-in vivo extrapolation (IVIVE) for predicting human intestinal absorption and first-pass elimination of drugs: principles and applications.Vitamin E-drug interactions: molecular basis and clinical relevance.Dealing with the complex drug-drug interactions: towards mechanistic models.Aluminum enhances inflammation and decreases mucosal healing in experimental colitis in mice.Molecular and cellular studies on the absorption, function, and safety of food components in intestinal epithelial cells.Involvement of cytochrome P450 3A4 and P-glycoprotein in first-pass intestinal extraction of omeprazole in rabbits.Effects of long-term ethanol consumption and Aldh1b1 depletion on intestinal tumourigenesis in mice.Gastrointestinal interactions, absorption, splanchnic metabolism and pharmacokinetics of orally ingested phenolic compounds.Why oral opioids may not be effective in a subset of chronic pain patients.Pharmacokinetic and pharmacodynamic interaction between nifedipine and metformin in rats: competitive inhibition for metabolism of nifedipine and metformin by each other via CYP isozymes.Evaluation of the synergistic effect of Allium sativum, Eugenia jambolana, Momordica charantia, Ocimum sanctum, and Psidium guajava on hepatic and intestinal drug metabolizing enzymes in rats.Characterization of the transmembrane transport and absolute bioavailability of the HCV protease inhibitor danoprevir.Identification of the principal transcriptional regulators for low-fat and high-fat meal responsive genes in small intestinePharmacokinetics of mirodenafil and its two metabolites, SK3541 and SK3544, after intravenous and oral administration of mirodenafil to streptozotocin-induced diabetes mellitus rats.
P2860
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P2860
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
The small intestine as a xenobiotic-metabolizing organ.
@ast
The small intestine as a xenobiotic-metabolizing organ.
@en
type
label
The small intestine as a xenobiotic-metabolizing organ.
@ast
The small intestine as a xenobiotic-metabolizing organ.
@en
prefLabel
The small intestine as a xenobiotic-metabolizing organ.
@ast
The small intestine as a xenobiotic-metabolizing organ.
@en
P356
P1476
The small intestine as a xenobiotic-metabolizing organ.
@en
P2093
Laurence S Kaminsky
Qing-Yu Zhang
P304
P356
10.1124/DMD.31.12.1520
P577
2003-12-01T00:00:00Z