Improving both aqueous solubility and anti-cancer activity by assessing progressive lead optimization libraries.

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Novel Natural Product- and Privileged Scaffold-Based Tubulin Inhibitors Targeting the Colchicine Binding Site From fighting depression to conquering tumors: a novel tricyclic thiazepine compound as a tubulin polymerization inhibitor

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Improving both aqueous solubility and anti-cancer activity by assessing progressive lead optimization libraries.

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http://www.wikidata.org/entity/Q35591252

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2015 nî lūn-bûn

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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2015年论文

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2015年论文

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name

Improving both aqueous solubil ...... e lead optimization libraries.

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Improving both aqueous solubil ...... e lead optimization libraries.

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Improving both aqueous solubil ...... e lead optimization libraries.

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Improving both aqueous solubil ...... e lead optimization libraries.

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Improving both aqueous solubil ...... e lead optimization libraries.

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Improving both aqueous solubil ...... e lead optimization libraries.

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P1476

Improving both aqueous solubil ...... ve lead optimization libraries

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P2093

Bing Yan

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Fei Li

http://www.w3.org/2001/XMLSchema#string

Hao Zhu

http://www.w3.org/2001/XMLSchema#string

Qiu Zhang

http://www.w3.org/2001/XMLSchema#string

Wenyi Wang

http://www.w3.org/2001/XMLSchema#string

Yin Liu

http://www.w3.org/2001/XMLSchema#string

P2860

Drug-like properties and the causes of poor solubility and poor permeability.

Design, synthesis, cytoselective toxicity, structure-activity relationships, and pharmacophore of thiazolidinone derivatives targeting drug-resistant lung cancer cells.

Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy.

Antitumor activity of (2E,5Z)-5-(2-hydroxybenzylidene)-2-((4-phenoxyphenyl)imino) thiazolidin-4-one, a novel microtubule-depolymerizing agent, in U87MG human glioblastoma cells and corresponding mouse xenograft model.

Bridging solubility between drug discovery and development.

Anti-tumor selectivity of a novel tubulin and HSP90 dual-targeting inhibitor in non-small cell lung cancer models.

Functionalized indoleamines as potent, drug-like inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt).

Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States.

Amino derivatives of indole as potent inhibitors of isoprenylcysteine carboxyl methyltransferase.

Discovery of small molecule integrin alphavbeta3 antagonists as novel anticancer agents.

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1971-1975

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scholarly article

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10.1016/J.BMCL.2015.03.016

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English

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http://www.w3.org/2001/XMLSchema#string

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L Wu

Hongyu Zhou

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2015-03-14T00:00:00Z

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273578719

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25827524

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5586103

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Improving both aqueous solubility and anti-cancer activity by assessing progressive lead optimization libraries.

about

P2860

P2860

Improving both aqueous solubility and anti-cancer activity by assessing progressive lead optimization libraries.

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P5875

P698

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P5875

P698

P932