Mitotic recombination produces the majority of recessive fibroblast variants in heterozygous mice.
about
Embryonic stem cells and somatic cells differ in mutation frequency and typeTelomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice.Inflammation-induced cell proliferation potentiates DNA damage-induced mutations in vivoMechanisms and consequences of somatic mosaicism in humansModulation of DNA end joining by nuclear proteinsOncogenic potential of the DNA replication licensing protein CDT1DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouseMlh1 mediates tissue-specific regulation of mitotic recombinationMultinucleated giant cells from fibroblast cultures.Mutagenesis of diploid mammalian genes by gene entrapment.Rosa26-GFP direct repeat (RaDR-GFP) mice reveal tissue- and age-dependence of homologous recombination in mammals in vivo.Deleterious mutations and selection for sex in finite diploid populationsSimulated space radiation-induced mutants in the mouse kidney display widespread genomic changeReplication stress induces micronuclei comprising of aggregated DNA double-strand breaksProduction of alpha-1,3-galactosyltransferase null pigs by means of nuclear transfer with fibroblasts bearing loss of heterozygosity mutations.Identification of human preformed antibody targets in GTKO pigs.Oxidative stress preferentially induces a subtype of micronuclei and mediates the genomic instability caused by p53 dysfunction."Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normallySIRT7 promotes genome integrity and modulates non-homologous end joining DNA repair.Extensive loss of heterozygosity is suppressed during homologous repair of chromosomal breaksCarcinogens induce genome-wide loss of heterozygosity in normal stem cells without persistent chromosomal instability.Homologous recombination conserves DNA sequence integrity throughout the cell cycle in embryonic stem cellsSpontaneous mitotic homologous recombination at an enhanced yellow fluorescent protein (EYFP) cDNA direct repeat in transgenic mice.Chromosome instability contributes to loss of heterozygosity in mice lacking p53Genome instability, cancer and aging.Ameiotic recombination in asexual lineages of Daphnia.Chromosome microduplication in somatic cells decreases the genetic stability of human reprogrammed somatic cells and results in pluripotent stem cells.Interchromosomal crossover in human cells is associated with long gene conversion tracts.Prdx1 deficiency in mice promotes tissue specific loss of heterozygosity mediated by deficiency in DNA repair and increased oxidative stress.X-rays induce distinct patterns of somatic mutation in fetal versus adult hematopoietic cells.Chronic centrosome amplification without tumorigenesis.Mitotic Intragenic Recombination: A Mechanism of Survival for Several Congenital Disorders of GlycosylationRole of the mismatch repair gene, Msh6, in suppressing genome instability and radiation-induced mutations.Ionizing radiation is a potent inducer of mitotic recombination in mouse embryonic stem cells.Chemokine receptor CXCR2 is transactivated by p53 and induces p38-mediated cellular senescence in response to DNA damage.Somatic recombination in adult tissues: What is there to learn?Recombinant cells in the lung increase with age via de novo recombination events and clonal expansion.CEL-Seq2: sensitive highly-multiplexed single-cell RNA-Seq.Liver carcinogen aflatoxin B1 as an inducer of mitotic recombination in a human cell line.Spontaneously immortalized cell lines obtained from adult Atm null mice retain sensitivity to ionizing radiation and exhibit a mutational pattern suggestive of oxidative stress.
P2860
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P2860
Mitotic recombination produces the majority of recessive fibroblast variants in heterozygous mice.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Mitotic recombination produces ...... variants in heterozygous mice.
@ast
Mitotic recombination produces ...... variants in heterozygous mice.
@en
type
label
Mitotic recombination produces ...... variants in heterozygous mice.
@ast
Mitotic recombination produces ...... variants in heterozygous mice.
@en
prefLabel
Mitotic recombination produces ...... variants in heterozygous mice.
@ast
Mitotic recombination produces ...... variants in heterozygous mice.
@en
P2093
P2860
P356
P1476
Mitotic recombination produces ...... variants in heterozygous mice
@en
P2093
P2860
P304
P356
10.1073/PNAS.96.16.9230
P407
P577
1999-08-01T00:00:00Z