Protein-protein interactions in Cdk5 regulation and function.
about
Alpha-chimaerin exists in a functional complex with the Cdk5 kinase in brainGene expression pattern in PC12 cells with reduced PMCA2 or PMCA3 isoform: selective up-regulation of calmodulin and neuromodulinCdk5/p35 phosphorylates mSds3 and regulates mSds3-mediated repression of transcriptionActin interaction and regulation of cyclin-dependent kinase 5/p35 complex activityA 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation.TFP5, a Peptide Inhibitor of Aberrant and Hyperactive Cdk5/p25, Attenuates Pathological Phenotypes and Restores Synaptic Function in CK-p25Tg Mice.The Cdk5 activator P39 specifically links muskelin to myosin II and regulates stress fiber formation and actin organization in lens.Peptide TFP5/TP5 derived from Cdk5 activator P35 provides neuroprotection in the MPTP model of Parkinson's disease.Negative regulation of cyclin-dependent kinase 5 targets by protein kinase CThe atypical kinase Cdk5 is activated by insulin, regulates the association between GLUT4 and E-Syt1, and modulates glucose transport in 3T3-L1 adipocytesActivated cyclin-dependent kinase 5 promotes microglial phagocytosis of fibrillar β-amyloid by up-regulating lipoprotein lipase expressionTransient enhancement of proliferation of neural progenitors and impairment of their long-term survival in p25 transgenic mice.The interaction of Munc 18 (p67) with the p10 domain of p35 protects in vivo Cdk5/p35 activity from inhibition by TFP5, a peptide derived from p35.Calmodulin binding and Cdk5 phosphorylation of p35 regulate its effect on microtubules.Varicella-zoster virus IE63 protein phosphorylation by roscovitine-sensitive cyclin-dependent kinases modulates its cellular localization and activity.Protein kinase CK2 is an inhibitor of the neuronal Cdk5 kinase.CDK5-dependent phosphorylation of the Rho family GTPase TC10(alpha) regulates insulin-stimulated GLUT4 translocation.Characterization of the CDK5 gene in Apis cerana cerana (AccCDK5) and a preliminary identification of its activator gene, AccCDK5r1.Microtubule association of the neuronal p35 activator of Cdk5.Cyclin D1, cdk4, and Bim are involved in thrombin-induced apoptosis in cultured cortical neurons.Regulation of s6 kinase 1 activation by phosphorylation at ser-411.The neuronal p35 activator of Cdk5 is a novel F-actin binding and bundling protein.
P2860
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P2860
Protein-protein interactions in Cdk5 regulation and function.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Protein-protein interactions in Cdk5 regulation and function.
@ast
Protein-protein interactions in Cdk5 regulation and function.
@en
type
label
Protein-protein interactions in Cdk5 regulation and function.
@ast
Protein-protein interactions in Cdk5 regulation and function.
@en
prefLabel
Protein-protein interactions in Cdk5 regulation and function.
@ast
Protein-protein interactions in Cdk5 regulation and function.
@en
P2093
P356
P1433
P1476
Protein-protein interactions in Cdk5 regulation and function.
@en
P2093
Anthony C B Lim
Robert Z Qi
P304
P356
10.1159/000074625
P577
2003-09-01T00:00:00Z