Charge-mediated influence of the antibody variable domain on FcRn-dependent pharmacokinetics. - Wikidata - wikimedia - TriplyDB

Charge-mediated influence of the antibody variable domain on FcRn-dependent pharmacokinetics.

Charge-mediated influence of the antibody variable domain on FcRn-dependent pharmacokinetics.

http://www.wikidata.org/entity/Q35616449

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Key factors influencing ADME properties of therapeutic proteins: A need for ADME characterization in drug discovery and development Impact of SPR biosensor assay configuration on antibody: Neonatal Fc receptor binding data.Evaluating the Use of Antibody Variable Region (Fv) Charge as a Risk Assessment Tool for Predicting Typical Cynomolgus Monkey Pharmacokinetics Pharmacokinetic properties of IgG and various Fc fusion proteins in mice.Aberrant bispecific antibody pharmacokinetics linked to liver sinusoidal endothelium clearance mechanism in cynomolgus monkeys Biophysical properties of the clinical-stage antibody landscape.Half-life extended biotherapeutics.Biological therapy targeting the IL-23/IL-17 axis in inflammatory bowel disease.Pharmacokinetics of monoclonal antibodies and Fc-fusion proteins.Assessment of disulfide and hinge modifications in monoclonal antibodies Pharmacokinetic de-risking tools for selection of monoclonal antibody lead candidates.Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo.Target-independent variable region mediated effects on antibody clearance can be FcRn independent.The interplay of non-specific binding, target-mediated clearance and FcRn interactions on the pharmacokinetics of humanized antibodies.Conformational Destabilization of Immunoglobulin G Increases the Low pH Binding Affinity with the Neonatal Fc Receptor.Enrichment of high affinity subclasses and glycoforms from serum-derived IgG using FcγRs as affinity ligands.A role for macromolecular crowding in off-target binding of therapeutic antibodies.A Two-pronged Binding Mechanism of IgG to the Neonatal Fc Receptor Controls Complex Stability and IgG Serum Half-life.Evaluation of an FcRn affinity chromatographic method for IgG1-type antibodies and evaluation of IgG variants.A human endothelial cell-based recycling assay for screening of FcRn targeted molecules.Modulation of protein A binding allows single-step purification of mouse bispecific antibodies that retain FcRn binding.Changes in complementarity-determining regions significantly alter IgG binding to the neonatal Fc receptor (FcRn) and pharmacokinetics.

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P2860

Charge-mediated influence of the antibody variable domain on FcRn-dependent pharmacokinetics.

http://www.wikidata.org/entity/Q35616449

description

2015 nî lūn-bûn

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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2015年论文

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2015年论文

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Charge-mediated influence of t ...... Rn-dependent pharmacokinetics.

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Charge-mediated influence of t ...... Rn-dependent pharmacokinetics.

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type

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Charge-mediated influence of t ...... Rn-dependent pharmacokinetics.

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Charge-mediated influence of t ...... Rn-dependent pharmacokinetics.

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Charge-mediated influence of t ...... Rn-dependent pharmacokinetics.

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Charge-mediated influence of t ...... Rn-dependent pharmacokinetics.

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PNAS.1408766112

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Proceedings of the National Academy of Sciences of the United States of America

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Charge-mediated influence of t ...... cRn-dependent pharmacokinetics

@en

P2093

Angela Schoch

http://www.w3.org/2001/XMLSchema#string

Gerhard Winter

http://www.w3.org/2001/XMLSchema#string

Hubert Kettenberger

http://www.w3.org/2001/XMLSchema#string

Julia Engert

http://www.w3.org/2001/XMLSchema#string

Julia Heinrich

http://www.w3.org/2001/XMLSchema#string

Olaf Mundigl

http://www.w3.org/2001/XMLSchema#string

P2860

Neonatal Fc receptor mediates internalization of Fc in transfected human endothelial cells

The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan

Crystal structure at 2.8 A of an FcRn/heterodimeric Fc complex: mechanism of pH-dependent binding

Structural basis for the dual recognition of IL-12 and IL-23 by ustekinumab

An Fc receptor structurally related to MHC class I antigens

pH-dependent binding of immunoglobulins to intestinal cells of the neonatal rat.

From sorting endosomes to exocytosis: association of Rab4 and Rab11 GTPases with the Fc receptor, FcRn, during recycling.

Elucidation of intracellular recycling pathways leading to exocytosis of the Fc receptor, FcRn, by using multifocal plane microscopy.

The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity.

Analyses of the recycling receptor, FcRn, in live cells reveal novel pathways for lysosomal delivery.

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scholarly article

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10.1073/PNAS.1408766112

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112

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25918417

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4434771

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