Glycopeptide enkephalin analogues produce analgesia in mice: evidence for penetration of the blood-brain barrier.
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Supramolecular Complexation of Carbohydrates for the Bioavailability Enhancement of Poorly Soluble DrugsLipid- and sugar-modified endomorphins: novel targets for the treatment of neuropathic painCNS active O-linked glycopeptidesA drug delivery strategy: binding enkephalin to asialoglycoprotein receptor by enzymatic galactosylationDevelopment of neuropeptide drugs that cross the blood-brain barrier.Glycosylation, an effective synthetic strategy to improve the bioavailability of therapeutic peptides.Novel pentameric thiophene derivatives for in vitro and in vivo optical imaging of a plethora of protein aggregates in cerebral amyloidoses.Investigation of glucose-modified liposomes using polyethylene glycols with different chain lengths as the linkers for brain targeting.New potent biphalin analogues containing p-fluoro-L-phenylalanine at the 4,4' positions and non-hydrazine linkers.Evidence for P-glycoprotein-modulated penetration of morphine-6-glucuronide into brain capillary endothelium.Prodrug based optimal drug delivery via membrane transporter/receptor.Production of antinociception by peripheral administration of [Lys7]dermorphin, a naturally occurring peptide with high affinity for mu-opioid receptors.Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists.Functional loss of ABCA1 in mice causes severe placental malformation, aberrant lipid distribution, and kidney glomerulonephritis as well as high-density lipoprotein cholesterol deficiency.Opioid glycopeptide analgesics derived from endogenous enkephalins and endorphinsThe mixed-action delta/mu opioid agonist MMP-2200 does not produce conditioned place preference but does maintain drug self-administration in rats, and induces in vitro markers of tolerance and dependenceCNS drug delivery: opioid peptides and the blood-brain barrierImproving metabolic stability by glycosylation: bifunctional peptide derivatives that are opioid receptor agonists and neurokinin 1 receptor antagonistsDesign, synthesis, and biological evaluation of novel bifunctional C-terminal-modified peptides for delta/mu opioid receptor agonists and neurokinin-1 receptor antagonists.Polymeric nanoparticles for the drug delivery to the central nervous system.Formed and preformed metabolites: facts and comparisons.Endomorphins: potential roles and therapeutic indications in the development of opioid peptide analgesic drugs.Novel and emerging strategies in drug delivery for overcoming the blood-brain barrier.Shuttle-mediated drug delivery to the brain.Strategies for therapy of retinal diseases using systemic drug delivery: relevance of transporters at the blood-retinal barrier.Morphine metabolism, transport and brain disposition.Opioid receptor targeting ligands for pain management: a review and update.Advances in brain drug targeting and delivery: limitations and challenges of solid lipid nanoparticles.Transporter-Mediated Disposition of Opioids: Implications for Clinical Drug Interactions.Glucose Transporters at the Blood-Brain Barrier: Function, Regulation and Gateways for Drug Delivery.Combating malaria with nanotechnology-based targeted and combinatorial drug delivery strategies.The influence of active transport systems on morphine -6-glucuronide transport in MDCKII and MDCK-PGP cellsBrain-targeted polymeric nanoparticles: in vivo evidence of different routes of administration in rodents.Evidence of active transport involvement in morphine transport via MDCKII and MDCK-PGP cell lines.In Vitro Membrane Permeation Studies and in Vivo Antinociception of Glycosylated Dmt(1)-DALDA Analogues.Glycosylated cell-penetrating peptides and their conjugates to a proapoptotic peptide: preparation by click chemistry and cell viability studies.Assessment of stereoselectivity of trimethylphenylalanine analogues of delta-opioid [D-Pen(2),D-Pen(5)]-enkephalin.mRna expression and transport characterization of conditionally immortalized rat brain capillary endothelial cell lines; a new in vitro BBB model for drug targeting.The blood-brain barrier: principles for targeting peptides and drugs to the central nervous system.Novel cyclic biphalin analogue with improved antinociceptive properties.
P2860
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P2860
Glycopeptide enkephalin analogues produce analgesia in mice: evidence for penetration of the blood-brain barrier.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Glycopeptide enkephalin analog ...... on of the blood-brain barrier.
@ast
Glycopeptide enkephalin analog ...... on of the blood-brain barrier.
@en
type
label
Glycopeptide enkephalin analog ...... on of the blood-brain barrier.
@ast
Glycopeptide enkephalin analog ...... on of the blood-brain barrier.
@en
prefLabel
Glycopeptide enkephalin analog ...... on of the blood-brain barrier.
@ast
Glycopeptide enkephalin analog ...... on of the blood-brain barrier.
@en
P2093
P2860
P356
P1476
Glycopeptide enkephalin analog ...... ion of the blood-brain barrier
@en
P2093
H I Yamamura
T J Abbruscato
P2860
P304
P356
10.1073/PNAS.91.15.7114
P407
P577
1994-07-01T00:00:00Z