Recent development of multifunctional agents as potential drug candidates for the treatment of Alzheimer's disease.
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Multiple Targeting Approaches on Histamine H3 Receptor AntagonistsNavigating the Chemical Space of Multitarget-Directed Ligands: From Hybrids to Fragments in Alzheimer's DiseaseAn overview on therapeutics attenuating amyloid β level in Alzheimer's disease: targeting neurotransmission, inflammation, oxidative stress and enhanced cholesterol levelsMonoaminergic Mechanisms in Epilepsy May Offer Innovative Therapeutic Opportunity for Monoaminergic Multi-Target DrugsKey Targets for Multi-Target Ligands Designed to Combat NeurodegenerationTraditional Chinese Nootropic Medicine Radix Polygalae and Its Active Constituent Onjisaponin B Reduce β-Amyloid Production and Improve Cognitive ImpairmentsAlzhCPI: A knowledge base for predicting chemical-protein interactions towards Alzheimer's disease.Multigram synthesis and in vivo efficacy studies of a novel multitarget anti-Alzheimer's compound.Exploration of a Library of 3,4-(Methylenedioxy)aniline-Derived Semicarbazones as Dual Inhibitors of Monoamine Oxidase and Acetylcholinesterase: Design, Synthesis, and Evaluation.Structure-activity relationship studies of benzyl-, phenethyl-, and pyridyl-substituted tetrahydroacridin-9-amines as multitargeting agents to treat Alzheimer's disease.Conjugates of γ-Carbolines and Phenothiazine as new selective inhibitors of butyrylcholinesterase and blockers of NMDA receptors for Alzheimer DiseaseNovel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer's Agents: Design, Synthesis and Biological Evaluation.The Potential Roles of Aquaporin 4 in Alzheimer's Disease.Molecular insights into Aβ42 protofibril destabilization with a fluorinated compound D744: A molecular dynamics simulation study.Dual/multitargeted xanthone derivatives for Alzheimer's disease: where do we stand?Multitarget drug design strategy in Alzheimer's disease: focus on cholinergic transmission and amyloid-β aggregation.Natural Xanthones from Garcinia mangostana with Multifunctional Activities for the Therapy of Alzheimer's Disease.Recent progress in repositioning Alzheimer's disease drugs based on a multitarget strategy.Multitarget strategies in Alzheimer's disease: benefits and challenges on the road to therapeutics.Novel multitarget-directed tacrine derivatives as potential candidates for the treatment of Alzheimer's disease.MH84: A Novel γ-Secretase Modulator/PPARγ Agonist--Improves Mitochondrial Dysfunction in a Cellular Model of Alzheimer's Disease.Alzheimer Disease: Clues from traditional and complementary medicine.A Trishistidine Pseudopeptide with Ability to Remove Both CuΙ and CuΙΙ from the Amyloid-β Peptide and to Stop the Associated ROS Formation.Modulating Neurotrophin Receptor Signaling as a Therapeutic Strategy for Huntington's Disease.Advances toward multifunctional cholinesterase and β-amyloid aggregation inhibitors.Discovery of novel isoflavone derivatives as AChE/BuChE dual-targeted inhibitors: synthesis, biological evaluation and molecular modelling.Synthesis, molecular modeling, and biological evaluation of 4-[5-aryl-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl] benzenesulfonamides toward acetylcholinesterase, carbonic anhydrase I and II enzymes.Novel tetrahydroacridine derivatives with iodobenzoic acid moiety as multifunctional acetylcholinesterase inhibitors.Integrated Analysis of Alzheimer's Disease and Schizophrenia Dataset Revealed Different Expression Pattern in Learning and Memory.MH84 improves mitochondrial dysfunction in a mouse model of early Alzheimer's disease.Gene-gene interactions among coding genes of iron-homeostasis proteins and APOE-alleles in cognitive impairment diseases.Synthesis, Molecular Modelling and Biological Evaluation of Novel Heterodimeric, Multiple Ligands Targeting Cholinesterases and Amyloid Beta.Special Issue: "Molecules against Alzheimer".Application of Strep-Tactin XT for affinity purification of Twin-Strep-tagged CB2, a G protein-coupled cannabinoid receptor.Changing paradigm from one target one ligand towards multi target directed ligand design for key drug targets of Alzheimer disease: An important role of Insilco methods in multi target directed ligands design.Phthalimide-Derived N-Benzylpyridinium Halides Targeting Cholinesterases: Synthesis and Bioactivity of New Potential Anti-Alzheimer's Disease Agents.Naringin Dihydrochalcone Ameliorates Cognitive Deficits and Neuropathology in APP/PS1 Transgenic Mice.Computer-Aided Multi-Target Management of Emergent Alzheimer's Disease.Bis(9)-(-)-Meptazinol, a novel dual-binding AChE inhibitor, rescues cognitive deficits and pathological changes in APP/PS1 transgenic mice
P2860
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P2860
Recent development of multifunctional agents as potential drug candidates for the treatment of Alzheimer's disease.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Recent development of multifun ...... atment of Alzheimer's disease.
@ast
Recent development of multifun ...... atment of Alzheimer's disease.
@en
type
label
Recent development of multifun ...... atment of Alzheimer's disease.
@ast
Recent development of multifun ...... atment of Alzheimer's disease.
@en
prefLabel
Recent development of multifun ...... atment of Alzheimer's disease.
@ast
Recent development of multifun ...... atment of Alzheimer's disease.
@en
P2093
P2860
P1476
Recent development of multifun ...... eatment of Alzheimer's disease
@en
P2093
Barbara Malawska
Dawid Panek
Natalia Guzior
P2860
P304
P356
10.2174/0929867321666141106122628
P5008
P577
2015-01-01T00:00:00Z