Mechanisms of inactivation of mismatch repair genes in human colorectal cancer cell lines: the predominant role of hMLH1.
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The interaction of DNA mismatch repair proteins with human exonuclease IEpigenetic silencing of AXIN2 in colorectal carcinoma with microsatellite instabilityModulation of mismatch repair and genomic stability by miR-155A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell linesFrequent hypermethylation of the hMLH1 gene promoter in differentiated-type tumors of the stomach with the gastric foveolar phenotypeChfr inactivation is not associated to chromosomal instability in colon cancersElevated mutant frequencies and increased C : G-->T : A transitions in Mlh1-/- versus Pms2-/- murine small intestinal epithelial cellsDNA hypermethylation of tumor-related genes in gastric carcinomaInvolvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells.DNA mismatch repair genes and colorectal cancer.Pharmacogenetics research on chemotherapy resistance in colorectal cancer over the last 20 yearsDNA methyltransferases, DNA damage repair, and cancerSpectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement.APC mutations in sporadic colorectal tumors: A mutational "hotspot" and interdependence of the "two hits"The role of hypermethylation of the hMLH1 promoter region in HNPCC versus MSI+ sporadic colorectal cancersAn insight into the genetic pathway of adenocarcinoma of the small intestineEpigenomic analysis of aberrantly methylated genes in colorectal cancer identifies genes commonly affected by epigenetic alterations.Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes.Cell growth, global phosphotyrosine elevation, and c-Met phosphorylation through Src family kinases in colorectal cancer cellsMethylation of hMLH1 promoter correlates with the gene silencing with a region-specific manner in colorectal cancerImpairment of MLH1 and CDKN2A in oncogenesis of laryngeal cancer.Evolutionary dynamics of tumor suppressor gene inactivation.Predictive and prognostic factors in colorectal cancer: a personalized approach.Ellagitannin-rich cloudberry inhibits hepatocyte growth factor induced cell migration and phosphatidylinositol 3-kinase/AKT activation in colon carcinoma cells and tumors in Min mice.Multiple rare variants in different genes account for multifactorial inherited susceptibility to colorectal adenomas.Microsatellite instability in metastatic colorectal cancer: a review of pathology, response to chemotherapy and clinical outcome.Germline, somatic and epigenetic events underlying mismatch repair deficiency in colorectal and HNPCC-related cancers.Differential expression of CD133 based on microsatellite instability status in human colorectal cancer.S-phase-specific radiosensitization by gemcitabine for therapeutic carbon ion exposure in vitro.The Role of Stem Cell DNA Methylation in Colorectal Carcinogenesis.Biological validation that SF3b is a target of the antitumor macrolide pladienolide.S-phase cell-specific modification by gemcitabine of PFGE-analyzed radiation-induced DNA fragmentation and rejoining.Restoring mismatch repair does not stop the formation of reciprocal translocations in the colon cancer cell line HCA7 but further destabilizes chromosome number.Mutation frequency in coding and non-coding repeat sequences in mismatch repair deficient cells derived from normal human tissue.Identification and functional characterization of the promoter region of the human MSH6 gene.Hypermethylation of the promoter region of the E-cadherin gene (CDH1) in sporadic and ulcerative colitis associated colorectal cancer.Gene expression signatures for colorectal cancer microsatellite status and HNPCC.DUOX2 and DUOXA2 form the predominant enzyme system capable of producing the reactive oxygen species H2O2 in active ulcerative colitis and are modulated by 5-aminosalicylic acid.New insights into the molecular mechanism of Boletus edulis ribonucleic acid fraction (BE3) concerning antiproliferative activity on human colon cancer cells.Extensive characterization of genetic alterations in a series of human colorectal cancer cell lines.
P2860
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P2860
Mechanisms of inactivation of mismatch repair genes in human colorectal cancer cell lines: the predominant role of hMLH1.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Mechanisms of inactivation of ...... the predominant role of hMLH1.
@ast
Mechanisms of inactivation of ...... the predominant role of hMLH1.
@en
type
label
Mechanisms of inactivation of ...... the predominant role of hMLH1.
@ast
Mechanisms of inactivation of ...... the predominant role of hMLH1.
@en
prefLabel
Mechanisms of inactivation of ...... the predominant role of hMLH1.
@ast
Mechanisms of inactivation of ...... the predominant role of hMLH1.
@en
P2093
P2860
P356
P1476
Mechanisms of inactivation of ...... the predominant role of hMLH1.
@en
P2093
I P Tomlinson
J M Wheeler
N J Mortensen
P2860
P304
10296-10301
P356
10.1073/PNAS.96.18.10296
P407
P577
1999-08-01T00:00:00Z