Serum choline activates mutant acetylcholine receptors that cause slow channel congenital myasthenic syndromes
about
Activation of endplate nicotinic acetylcholine receptors by agonistsActivation of muscle nicotinic acetylcholine receptor channels by nicotinic and muscarinic agonistsMapping the agonist binding site of the nicotinic acetylcholine receptor. Orientation requirements for activation by covalent agonistPoint mutant mice with hypersensitive alpha 4 nicotinic receptors show dopaminergic deficits and increased anxiety.Dynamics of the acetylcholine receptor pore at the gating transition state.A speed limit for conformational change of an allosteric membrane protein.Acetylcholine receptors and myasthenia.Conserved allosteric hot spots in the transmembrane domains of cystic fibrosis transmembrane conductance regulator (CFTR) channels and multidrug resistance protein (MRP) pumps.Plasticity of acetylcholine receptor gating motions via rate-energy relationships.Design and control of acetylcholine receptor conformational changeGlycine hinges with opposing actions at the acetylcholine receptor-channel transmitter binding site.Life at the top: the transition state of AChR gating.Role of pairwise interactions between M1 and M2 domains of the nicotinic receptor in channel gatingThe intrinsic energy of the gating isomerization of a neuromuscular acetylcholine receptor channel.A mechanistic description of gating of the human cardiac ryanodine receptor in a regulated minimal environment.Block of muscle nicotinic receptors by choline suggests that the activation and desensitization gates act as distinct molecular entities.Acetylcholine receptor gating at extracellular transmembrane domain interface: the cys-loop and M2-M3 linker.Asymmetric and independent contribution of the second transmembrane segment 12' residues to diliganded gating of acetylcholine receptor channels: a single-channel study with choline as the agonistKinetic, mechanistic, and structural aspects of unliganded gating of acetylcholine receptor channels: a single-channel study of second transmembrane segment 12' mutants.The extracellular linker of muscle acetylcholine receptor channels is a gating control element.Action of nicotine and analogs on acetylcholine receptors having mutations of transmitter-binding site residue αG153Investigation of Congenital Myasthenia Reveals Functional Asymmetry of Invariant Acetylcholine Receptor (AChR) Cys-loop Aspartates.Energy for wild-type acetylcholine receptor channel gating from different choline derivativesFunction of interfacial prolines at the transmitter-binding sites of the neuromuscular acetylcholine receptor.Converting nonhydrolyzable nucleotides to strong cystic fibrosis transmembrane conductance regulator (CFTR) agonists by gain of function (GOF) mutationsUnliganded gating of acetylcholine receptor channelsThe gating isomerization of neuromuscular acetylcholine receptors.The energy and work of a ligand-gated ion channel.Activation and block of the adult muscle-type nicotinic receptor by physostigmine: single-channel studies.Activation of heteroliganded mouse muscle nicotinic receptors.The role of loop 5 in acetylcholine receptor channel gating.Properties of the human muscle nicotinic receptor, and of the slow-channel myasthenic syndrome mutant epsilonL221F, inferred from maximum likelihood fits.Arg-274 and Leu-277 of the gamma-aminobutyric acid type A receptor alpha 2 subunit define agonist efficacy and potency.Mapping the conformational wave of acetylcholine receptor channel gating.Mutations Causing Slow-Channel Myasthenia Reveal That a Valine Ring in the Channel Pore of Muscle AChR is Optimized for Stabilizing Channel Gating.Acetylcholine receptor gating in a zebrafish model for slow-channel syndrome.Activation and block of mouse muscle-type nicotinic receptors by tetraethylammonium.Mechanistic contributions of residues in the M1 transmembrane domain of the nicotinic receptor to channel gating.Gating dynamics of the acetylcholine receptor extracellular domain.Determinants of the anesthetic sensitivity of neuronal nicotinic acetylcholine receptors.
P2860
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P2860
Serum choline activates mutant acetylcholine receptors that cause slow channel congenital myasthenic syndromes
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Serum choline activates mutant ...... ongenital myasthenic syndromes
@ast
Serum choline activates mutant ...... ongenital myasthenic syndromes
@en
type
label
Serum choline activates mutant ...... ongenital myasthenic syndromes
@ast
Serum choline activates mutant ...... ongenital myasthenic syndromes
@en
prefLabel
Serum choline activates mutant ...... ongenital myasthenic syndromes
@ast
Serum choline activates mutant ...... ongenital myasthenic syndromes
@en
P2093
P2860
P356
P1476
Serum choline activates mutant ...... ongenital myasthenic syndromes
@en
P2093
P2860
P304
10466-10471
P356
10.1073/PNAS.96.18.10466
P407
P577
1999-08-01T00:00:00Z