Nuclear localization of de novo thymidylate biosynthesis pathway is required to prevent uracil accumulation in DNA
about
Modeling cellular compartmentation in one-carbon metabolismPhosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insightsThymidine kinase 1 regulatory fine-tuning through tetramer formationA hybrid stochastic model of folate-mediated one-carbon metabolism: Effect of the common C677T MTHFR variant on de novo thymidylate biosynthesisAzoxymethane-induced colon carcinogenesis in mice occurs independently of de novo thymidylate synthesis capacity.A novel role of the tumor suppressor GNMT in cellular defense against DNA damage.Transcriptional activation and cell cycle block are the keys for 5-fluorouracil induced up-regulation of human thymidylate synthase expression.SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation.Human mutations in methylenetetrahydrofolate dehydrogenase 1 impair nuclear de novo thymidylate biosynthesis.Maternal dietary uridine causes, and deoxyuridine prevents, neural tube closure defects in a mouse model of folate-responsive neural tube defects.Aldehyde dehydrogenase homologous folate enzymes: Evolutionary switch between cytoplasmic and mitochondrial localization.Serine hydroxymethyltransferase anchors de novo thymidylate synthesis pathway to nuclear lamina for DNA synthesis.Dietary folic acid protects against genotoxicity in the red blood cells of mice.Transcriptomic profiling of TK2 deficient human skeletal muscle suggests a role for the p53 signalling pathway and identifies growth and differentiation factor-15 as a potential novel biomarker for mitochondrial myopathies.Functional characterization of drim2, the Drosophila melanogaster homolog of the yeast mitochondrial deoxynucleotide transporter.Dynamics of re-constitution of the human nuclear proteome after cell division is regulated by NLS-adjacent phosphorylation.Deoxyribonucleotide metabolism, mutagenesis and cancer.One-carbon metabolism in cancer.Give it or take it: the flux of one-carbon in cancer cells.One-Carbon Metabolism in Health and Disease.Targeting nuclear thymidylate biosynthesis.The Roles of SUMO in Metabolic Regulation.Arsenic trioxide targets MTHFD1 and SUMO-dependent nuclear de novo thymidylate biosynthesis.Screening and in vitro testing of antifolate inhibitors of human cytosolic serine hydroxymethyltransferase.DNA replication and mismatch repair safeguard against metabolic imbalances.Folate rescues vitamin B12 depletion-induced inhibition of nuclear thymidylate biosynthesis and genome instability.Partitioning of One-Carbon Units in Folate and Methionine Metabolism Is Essential for Neural Tube Closure.Human dihydrofolate reductase and thymidylate synthase form a complex in vitro and co-localize in normal and cancer cells.
P2860
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P2860
Nuclear localization of de novo thymidylate biosynthesis pathway is required to prevent uracil accumulation in DNA
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Nuclear localization of de nov ...... ent uracil accumulation in DNA
@ast
Nuclear localization of de nov ...... ent uracil accumulation in DNA
@en
type
label
Nuclear localization of de nov ...... ent uracil accumulation in DNA
@ast
Nuclear localization of de nov ...... ent uracil accumulation in DNA
@en
prefLabel
Nuclear localization of de nov ...... ent uracil accumulation in DNA
@ast
Nuclear localization of de nov ...... ent uracil accumulation in DNA
@en
P2093
P2860
P356
P1476
Nuclear localization of de nov ...... ent uracil accumulation in DNA
@en
P2093
Amanda J MacFarlane
Cheryll A Perry
Donald D Anderson
Patrick J Stover
Per Flodby
Robert H Allen
Sally P Stabler
P2860
P304
44015-44022
P356
10.1074/JBC.M111.307629
P407
P577
2011-11-04T00:00:00Z