Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII(atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model.
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The Role of Cyclo(His-Pro) in NeurodegenerationCopper Homeostasis as a Therapeutic Target in Amyotrophic Lateral Sclerosis with SOD1 MutationsMechanisms of mutant SOD1 induced mitochondrial toxicity in amyotrophic lateral sclerosisCopper delivery to the CNS by CuATSM effectively treats motor neuron disease in SOD(G93A) mice co-expressing the Copper-Chaperone-for-SODA faulty interaction between SOD1 and hCCS in neurodegenerative diseaseParsing Disease-relevant Protein Modifications from Epiphenomena: Perspective on the Structural Basis of SOD1-Mediated ALS.Inhibition of TDP-43 accumulation by bis(thiosemicarbazonato)-copper complexes.Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorderThe potential for transition metal-mediated neurodegeneration in amyotrophic lateral sclerosisNeuroprotective copper bis(thiosemicarbazonato) complexes promote neurite elongation.Genotype-property patient-phenotype relations suggest that proteome exhaustion can cause amyotrophic lateral sclerosis.Metal-deficient SOD1 in amyotrophic lateral sclerosis.The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease.Copper-boosting compounds: a novel concept for antimycobacterial drug discovery.P2X7 receptor-induced death of motor neurons by a peroxynitrite/FAS-dependent pathway.Increased metal content in the TDP-43(A315T) transgenic mouse model of frontotemporal lobar degeneration and amyotrophic lateral sclerosis.CuII(atsm) improves the neurological phenotype and survival of SOD1G93A mice and selectively increases enzymatically active SOD1 in the spinal cordMitochondrial metals as a potential therapeutic target in neurodegeneration.Copper as a key regulator of cell signalling pathways.The ER mitochondria calcium cycle and ER stress response as therapeutic targets in amyotrophic lateral sclerosis.Targeting mitochondrial metal dyshomeostasis for the treatment of neurodegeneration.Amyotrophic lateral sclerosis-like superoxide dismutase 1 proteinopathy is associated with neuronal loss in Parkinson's disease brain.Peptidylprolyl isomerase A governs TARDBP function and assembly in heterogeneous nuclear ribonucleoprotein complexes.Positron emission tomography in amyotrophic lateral sclerosis: Towards targeting of molecular pathological hallmarks.Insights into the mechanisms of copper dyshomeostasis in amyotrophic lateral sclerosis.Improving the Delivery of SOD1 Antisense Oligonucleotides to Motor Neurons Using Calcium Phosphate-Lipid Nanoparticles.Are Astrocytes the Predominant Cell Type for Activation of Nrf2 in Aging and Neurodegeneration?Cardioprotective effects of Cu(II)ATSM in human vascular smooth muscle cells and cardiomyocytes mediated by Nrf2 and DJ-1.Copper modulates the large dense core vesicle secretory pathway in PC12 cells.Therapeutic effects of CuII(atsm) in the SOD1-G37R mouse model of amyotrophic lateral sclerosis.The Copper bis(thiosemicarbazone) Complex CuII(atsm) Is Protective Against Cerebral Ischemia Through Modulation of the Inflammatory Milieu.Endogenous Cu in the central nervous system fails to satiate the elevated requirement for Cu in a mutant SOD1 mouse model of ALS.Deregulation of biometal homeostasis: the missing link for neuronal ceroid lipofuscinoses?ALSUntangled 43: copper.Redox metals homeostasis in multiple sclerosis and amyotrophic lateral sclerosis: a review.Cu(atsm) Attenuates NeuroinflammationTHEME 11 THERAPEUTIC STRATEGIES
P2860
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P2860
Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII(atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Diacetylbis(N(4)-methylthiosem ...... lateral sclerosis mouse model.
@ast
Diacetylbis(N(4)-methylthiosem ...... lateral sclerosis mouse model.
@en
Diacetylbis(N(4)-methylthiosem ...... lateral sclerosis mouse model.
@en-gb
type
label
Diacetylbis(N(4)-methylthiosem ...... lateral sclerosis mouse model.
@ast
Diacetylbis(N(4)-methylthiosem ...... lateral sclerosis mouse model.
@en
Diacetylbis(N(4)-methylthiosem ...... lateral sclerosis mouse model.
@en-gb
prefLabel
Diacetylbis(N(4)-methylthiosem ...... lateral sclerosis mouse model.
@ast
Diacetylbis(N(4)-methylthiosem ...... lateral sclerosis mouse model.
@en
Diacetylbis(N(4)-methylthiosem ...... lateral sclerosis mouse model.
@en-gb
P2093
P2860
P50
P356
P1476
Diacetylbis(N(4)-methylthiosem ...... lateral sclerosis mouse model.
@en
P2093
Cynthia P W Soon
James L Hickey
Janetta G Culvenor
Jiang-Li Tan
Julia Morizzi
Kevin J Barnham
Laura Bica
Lin W Hung
Nastasia K-H Lim
P2860
P304
44035-44044
P356
10.1074/JBC.M111.274407
P407
P50
P577
2011-10-27T00:00:00Z