Modeling evolutionary landscapes: mutational stability, topology, and superfunnels in sequence space.
about
Genes confer similar robustness to environmental, stochastic, and genetic perturbations in yeastEvolution favors protein mutational robustness in sufficiently large populationsQuasispecies theory in the context of population geneticsProtein stability promotes evolvabilityOn the conservative nature of intragenic recombinationThermodynamic prediction of protein neutralityMolecular clock in neutral protein evolutionThe structurally constrained protein evolution model accounts for sequence patterns of the LbetaH superfamilyStructure-guided engineering of Lactococcus lactis alcohol dehydrogenase LlAdhA for improved conversion of isobutyraldehyde to isobutanolPlasticity, evolvability, and modularity in RNAThermodynamics of neutral protein evolutionDoes mutational robustness inhibit extinction by lethal mutagenesis in viral populations?Evolutionary innovations and the organization of protein functions in genotype spaceComparing folding codes in simple heteropolymer models of protein evolutionary landscape: robustness of the superfunnel paradigm.A nonadaptive origin of a beneficial trait: in silico selection for free energy of folding leads to the neutral emergence of mutational robustness in single domain proteins.Occurrence of protein structure elements in conserved sequence regions.Computationally mapping sequence space to understand evolutionary protein engineering.Evolution, energy landscapes and the paradoxes of protein folding.Protein dynamism and evolvability.Theoretical Insights into the Biophysics of Protein Bi-stability and Evolutionary Switches.Biophysical Models of Protein Evolution: Understanding the Patterns of Evolutionary Sequence Divergence.Evolutionary dynamics on protein bi-stability landscapes can potentially resolve adaptive conflicts.Escape from Adaptive Conflict follows from weak functional trade-offs and mutational robustnessIn silico genetic robustness analysis of microRNA secondary structures: potential evidence of congruent evolution in microRNAComparison of translation loads for standard and alternative genetic codesA protein evolution model with independent sites that reproduces site-specific amino acid distributions from the Protein Data Bank.A first-principles model of early evolution: emergence of gene families, species, and preferred protein folds.Neutral evolution of protein-protein interactions: a computational study using simple models.The ascent of the abundant: how mutational networks constrain evolution.Universal distribution of protein evolution rates as a consequence of protein folding physicsMutation bias favors protein folding stability in the evolution of small populationsRecombinatoric exploration of novel folded structures: a heteropolymer-based model of protein evolutionary landscapesRoles of mutation and recombination in the evolution of protein thermodynamicsCoevolutionary information, protein folding landscapes, and the thermodynamics of natural selection.Smooth functional transition along a mutational pathway with an abrupt protein fold switch.Stability and the evolvability of function in a model proteinVisualizing fitness landscapes.Correlation between evolutionary structural development and protein folding.Biophysics of protein evolution and evolutionary protein biophysicsPredicting the tolerance of proteins to random amino acid substitution.
P2860
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P2860
Modeling evolutionary landscapes: mutational stability, topology, and superfunnels in sequence space.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Modeling evolutionary landscap ...... uperfunnels in sequence space.
@ast
Modeling evolutionary landscap ...... uperfunnels in sequence space.
@en
type
label
Modeling evolutionary landscap ...... uperfunnels in sequence space.
@ast
Modeling evolutionary landscap ...... uperfunnels in sequence space.
@en
prefLabel
Modeling evolutionary landscap ...... uperfunnels in sequence space.
@ast
Modeling evolutionary landscap ...... uperfunnels in sequence space.
@en
P2860
P356
P1476
Modeling evolutionary landscap ...... uperfunnels in sequence space.
@en
P2093
P2860
P304
10689-10694
P356
10.1073/PNAS.96.19.10689
P407
P577
1999-09-01T00:00:00Z