A catalytically silent FAAH-1 variant drives anandamide transport in neurons.
about
Targeting fatty acid binding protein (FABP) anandamide transporters - a novel strategy for development of anti-inflammatory and anti-nociceptive drugsAnandamide externally added to lipid vesicles containing trapped fatty acid amide hydrolase (FAAH) is readily hydrolyzed in a sterol-modulated fashionWhy do cannabinoid receptors have more than one endogenous ligand?Chemical probes of endocannabinoid metabolismA lipid gate for the peripheral control of painThe thrifty lipids: endocannabinoids and the neural control of energy conservation"Redundancy" of endocannabinoid inactivation: new challenges and opportunities for pain controlEndocannabinoids as biomarkers of human reproductionCannabidiol as a Potential New Type of an Antipsychotic. A Critical Review of the EvidenceThe endocannabinoid system as a potential therapeutic target for pain modulationFatty acid amide hydrolase inhibitors: a patent review (2009-2014)Inhibition of FAAH and activation of PPAR: new approaches to the treatment of cognitive dysfunction and drug addictionKetoconazole inhibits the cellular uptake of anandamide via inhibition of FAAH at pharmacologically relevant concentrationsThe evolution and comparative neurobiology of endocannabinoid signallingThe dual FAAH/MAGL inhibitor JZL195 has enhanced effects on endocannabinoid transmission and motor behavior in rats as compared to those of the MAGL inhibitor JZL184Endocannabinoid signaling and synaptic function.Cannabinoids and hallucinogens for headache.The role of endocannabinoids in pain modulation.Metabolism of endocannabinoids and related N-acylethanolamines: canonical and alternative pathways.Endocannabinoid 2-Arachidonoylglycerol Self-Administration by Sprague-Dawley Rats and Stimulation of in vivo Dopamine Transmission in the Nucleus Accumbens Shell.β-Lactones Inhibit N-acylethanolamine Acid Amidase by S-Acylation of the Catalytic N-Terminal Cysteine.Therapeutic Opportunities through the Modulation of Endocannabinoid Transport.Role of FAAH-like anandamide transporter in anandamide inactivation.Involvement of fatty acid amide hydrolase and fatty acid binding protein 5 in the uptake of anandamide by cell lines with different levels of fatty acid amide hydrolase expression: a pharmacological study.Hydrogen-bonded His93 as a sensitive probe for identifying inhibitors of the endocannabinoid transport protein FABP7.Fatty acid-binding proteins transport N-acylethanolamines to nuclear receptors and are targets of endocannabinoid transport inhibitors.The endocannabinoid system: an overview.The endocannabinoid transport inhibitor AM404 differentially modulates recognition memory in rats depending on environmental aversiveness.Characterization of the effects of reuptake and hydrolysis inhibition on interstitial endocannabinoid levels in the brain: an in vivo microdialysis studyEvidence for bidirectional endocannabinoid transport across cell membranesNeurobiological Interactions Between Stress and the Endocannabinoid System.Drug design for neuropathic pain regulation from traditional Chinese medicineProgramming of neural cells by (endo)cannabinoids: from physiological rules to emerging therapies.Self-administration of the anandamide transport inhibitor AM404 by squirrel monkeysThe interaction of fatty acid amide hydrolase (FAAH) inhibitors with an anandamide carrier protein using (19)F-NMR.Modulating the endocannabinoid system in human health and disease--successes and failuresDiacylglycerol lipase α manipulation reveals developmental roles for intercellular endocannabinoid signalingThe Structure-Function Relationships of Classical Cannabinoids: CB1/CB2 Modulation.Increased anandamide uptake by sensory neurons contributes to hyperalgesia in a model of cancer painEndocannabinoids and endovanilloids: a possible balance in the regulation of the testicular GnRH signalling
P2860
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P2860
A catalytically silent FAAH-1 variant drives anandamide transport in neurons.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
A catalytically silent FAAH-1 variant drives anandamide transport in neurons.
@ast
A catalytically silent FAAH-1 variant drives anandamide transport in neurons.
@en
type
label
A catalytically silent FAAH-1 variant drives anandamide transport in neurons.
@ast
A catalytically silent FAAH-1 variant drives anandamide transport in neurons.
@en
prefLabel
A catalytically silent FAAH-1 variant drives anandamide transport in neurons.
@ast
A catalytically silent FAAH-1 variant drives anandamide transport in neurons.
@en
P2093
P2860
P356
P1433
P1476
A catalytically silent FAAH-1 variant drives anandamide transport in neurons.
@en
P2093
Alessio Lodola
Ana Guijarro
Andrea Armirotti
Andrea Cavalli
Angelo Reggiani
Daniele Piomelli
Gianpiero Garau
Giovanni Bottegoni
P2507
P2860
P2888
P356
10.1038/NN.2986
P407
P577
2011-11-20T00:00:00Z
P5875
P6179
1043233601