Adenovirus ubiquitin-protein ligase stimulates viral late mRNA nuclear export.
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Oncolytic Replication of E1b-Deleted AdenovirusesA role for E1B-AP5 in ATR signaling pathways during adenovirus infectionAdenovirus E1B 55-kilodalton protein is a p53-SUMO1 E3 ligase that represses p53 and stimulates its nuclear export through interactions with promyelocytic leukemia nuclear bodies.The human adenovirus type 5 E1B 55 kDa protein obstructs inhibition of viral replication by type I interferon in normal human cells.Export of adenoviral late mRNA from the nucleus requires the Nxf1/Tap export receptor.The repression domain of the E1B 55-kilodalton protein participates in countering interferon-induced inhibition of adenovirus replication.Insight into the mechanism of inhibition of adeno-associated virus by the Mre11/Rad50/Nbs1 complexIntranuclear targeting and nuclear export of the adenovirus E1B-55K protein are regulated by SUMO1 conjugation.Timely synthesis of the adenovirus type 5 E1B 55-kilodalton protein is required for efficient genome replication in normal human cells.Changing the ubiquitin landscape during viral manipulation of the DNA damage response.Downregulation of Mdm2 and Mdm4 enhances viral gene expression during adenovirus infection.Role of the RNA recognition motif of the E1B 55 kDa protein in the adenovirus type 5 infectious cycle.Biophysical and functional analyses suggest that adenovirus E4-ORF3 protein requires higher-order multimerization to function against promyelocytic leukemia protein nuclear bodiesControl of mRNA export by adenovirus E4orf6 and E1B55K proteins during productive infection requires E4orf6 ubiquitin ligase activityE4Orf6-E1B-55k-dependent degradation of de novo-generated adeno-associated virus type 5 Rep52 and capsid proteins employs a cullin 5-containing E3 ligase complex.De novo derivation of proteomes from transcriptomes for transcript and protein identification.Cdc34p ubiquitin-conjugating enzyme is a component of the tombusvirus replicase complex and ubiquitinates p33 replication proteinRUNX1 permits E4orf6-directed nuclear localization of the adenovirus E1B-55K protein and associates with centers of viral DNA and RNA synthesisE4orf1 limits the oncolytic potential of the E1B-55K deletion mutant adenovirusIdentification of integrin alpha3 as a new substrate of the adenovirus E4orf6/E1B 55-kilodalton E3 ubiquitin ligase complexThe adenovirus E1B 55-kilodalton and E4 open reading frame 6 proteins limit phosphorylation of eIF2alpha during the late phase of infection.Adenovirus E1B 55-kilodalton protein: multiple roles in viral infection and cell transformation.Extensive post-translational modification of active and inactivated forms of endogenous p53.A proteomic approach to identify candidate substrates of human adenovirus E4orf6-E1B55K and other viral cullin-based E3 ubiquitin ligases.Emerging roles for ubiquitin in adenovirus cell entry.Adenovirus degradation of cellular proteins.DNA virus replication compartments.Viral subversion of nucleocytoplasmic traffickingThe ubiquitin-conjugating system: multiple roles in viral replication and infection.Comparison of protein expression during wild-type, and E1B-55k-deletion, adenovirus infection using quantitative time-course proteomics.Functional cooperation between human adenovirus type 5 early region 4, open reading frame 6 protein, and cellular homeobox protein HoxB7.Adenovirus E4orf3 targets transcriptional intermediary factor 1γ for proteasome-dependent degradation during infection.Serotype-specific inactivation of the cellular DNA damage response during adenovirus infection.The E4orf6/E1B55K E3 ubiquitin ligase complexes of human adenoviruses exhibit heterogeneity in composition and substrate specificity.Adeno-associated virus small rep proteins are modified with at least two types of polyubiquitination.Temporal regulation of the Mre11-Rad50-Nbs1 complex during adenovirus infection.Distinct requirements of adenovirus E1b55K protein for degradation of cellular substrates.Differential requirements of the C terminus of Nbs1 in suppressing adenovirus DNA replication and promoting concatemer formationThe Mre11/Rad50/Nbs1 complex limits adeno-associated virus transduction and replication.Adenovirus E4-ORF3-dependent relocalization of TIF1α and TIF1γ relies on access to the Coiled-Coil motif.
P2860
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P2860
Adenovirus ubiquitin-protein ligase stimulates viral late mRNA nuclear export.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Adenovirus ubiquitin-protein ligase stimulates viral late mRNA nuclear export.
@ast
Adenovirus ubiquitin-protein ligase stimulates viral late mRNA nuclear export.
@en
type
label
Adenovirus ubiquitin-protein ligase stimulates viral late mRNA nuclear export.
@ast
Adenovirus ubiquitin-protein ligase stimulates viral late mRNA nuclear export.
@en
prefLabel
Adenovirus ubiquitin-protein ligase stimulates viral late mRNA nuclear export.
@ast
Adenovirus ubiquitin-protein ligase stimulates viral late mRNA nuclear export.
@en
P2860
P356
P1433
P1476
Adenovirus ubiquitin-protein ligase stimulates viral late mRNA nuclear export.
@en
P2093
Arnold J Berk
Jennifer L Woo
P2860
P304
P356
10.1128/JVI.01725-06
P407
P577
2006-11-01T00:00:00Z