Hypoxia-induced acidosis uncouples the STIM-Orai calcium signaling complex - Wikidata - wikimedia - TriplyDB

Hypoxia-induced acidosis uncouples the STIM-Orai calcium signaling complex

Hypoxia-induced acidosis uncouples the STIM-Orai calcium signaling complex

http://www.wikidata.org/entity/Q35639811

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STIM proteins: dynamic calcium signal transducers Multifaceted roles of STIM proteins Redox regulation of store-operated Ca2+ entry Platelet-derived growth factor maintains stored calcium through a nonclustering Orai1 mechanism but evokes clustering if the endoplasmic reticulum is stressed by store depletion Protective role of acidic pH-activated chloride channel in severe acidosis-induced contraction from the aorta of spontaneously hypertensive rats.Potent functional uncoupling between STIM1 and Orai1 by dimeric 2-aminodiphenyl borinate analogs.Novel Protein Kinase C-Mediated Control of Orai1 Function in Invasive Melanoma.Identification of key amino acid residues responsible for internal and external pH sensitivity of Orai1/STIM1 channels.Store-operated Ca2+ entry supports contractile function in hearts of hibernators.Blockade of NOX2 and STIM1 signaling limits lipopolysaccharide-induced vascular inflammation Targeted STIM deletion impairs calcium homeostasis, NFAT activation, and growth of smooth muscle.STIM1/Orai1-mediated SOCE: current perspectives and potential roles in cardiac function and pathology Real-time dynamics of methyl-CpG-binding domain protein 3 and its role in DNA demethylation by fluorescence correlation spectroscopy.Emerging roles of Orai3 in pathophysiology.ROS and SOCE: recent advances and controversies in the regulation of STIM and Orai.Ca(2+) release-activated Ca(2+) (CRAC) current, structure, and function.Loss of endoplasmic reticulum Ca2+ homeostasis: contribution to neuronal cell death during cerebral ischemia.Changing calcium: CRAC channel (STIM and Orai) expression, splicing, and posttranslational modifiers.Differential Redox Regulation of Ca²⁺ Signaling and Viability in Normal and Malignant Prostate Cells.Distinct Orai-coupling domains in STIM1 and STIM2 define the Orai-activating site.Extracellular acidosis impairs P2Y receptor-mediated Ca(2+) signalling and migration of microglia.An insert-based enzymatic cell culture system to rapidly and reversibly induce hypoxia: investigations of hypoxia-induced cell damage, protein expression and phosphorylation in neuronal IMR-32 cells.Crosstalk between calcium and reactive oxygen species signaling in cancer.Regulation of Orai1/STIM1 mediated ICRAC by intracellular pH.Regulation of endogenous and heterologous Ca²⁺ release-activated Ca²⁺ currents by pH.Intracellular carbonic anhydrase activity sensitizes cancer cell pH signaling to dynamic changes in CO2 partial pressure.Cross talk between increased intracellular zinc (Zn2+) and accumulation of reactive oxygen species in chemical ischemia.The STIM-Orai Pathway: Regulation of STIM and Orai by Thiol Modifications.The Orai1 Store-operated Calcium Channel Functions as a Hexamer.Store-Operated Calcium Channels.

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Hypoxia-induced acidosis uncouples the STIM-Orai calcium signaling complex

http://www.wikidata.org/entity/Q35639811

description

2011 nî lūn-bûn

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

@zh-tw

2011年论文

@wuu

2011年论文

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2011年论文

@zh-cn

name

Hypoxia-induced acidosis uncouples the STIM-Orai calcium signaling complex

@ast

Hypoxia-induced acidosis uncouples the STIM-Orai calcium signaling complex

@en

type

label

Hypoxia-induced acidosis uncouples the STIM-Orai calcium signaling complex

@ast

Hypoxia-induced acidosis uncouples the STIM-Orai calcium signaling complex

@en

prefLabel

Hypoxia-induced acidosis uncouples the STIM-Orai calcium signaling complex

@ast

Hypoxia-induced acidosis uncouples the STIM-Orai calcium signaling complex

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JBC.M111.303081

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Journal of Biological Chemistry

P1476

Hypoxia-induced acidosis uncouples the STIM-Orai calcium signaling complex

@en

P2093

Donald L Gill

http://www.w3.org/2001/XMLSchema#string

Gavin Landesberg

http://www.w3.org/2001/XMLSchema#string

Karthik Mallilankaraman

http://www.w3.org/2001/XMLSchema#string

Muniswamy Madesh

http://www.w3.org/2001/XMLSchema#string

Reynold A Panettieri

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Rosario Scalia

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Salvatore Mancarella

http://www.w3.org/2001/XMLSchema#string

Xiang D Tang

http://www.w3.org/2001/XMLSchema#string

Xiaoxiang Deng

http://www.w3.org/2001/XMLSchema#string

Youjun Wang

http://www.w3.org/2001/XMLSchema#string

P2860

Orai1 and STIM reconstitute store-operated calcium channel function

STIM2 is an inhibitor of STIM1-mediated store-operated Ca2+ Entry

STIM2 is a feedback regulator that stabilizes basal cytosolic and endoplasmic reticulum Ca2+ levels

STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1

Hypoxia-inducible factors and the response to hypoxic stress

Signal integration in the endoplasmic reticulum unfolded protein response

Ischemic cell death in brain neurons

Potentiation and inhibition of Ca(2+) release-activated Ca(2+) channels by 2-aminoethyldiphenyl borate (2-APB) occurs independently of IP(3) receptors

Molecular basis of calcium signaling in lymphocytes: STIM and ORAI

S-glutathionylation activates STIM1 and alters mitochondrial homeostasis.

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10.1074/JBC.M111.303081

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52

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2011-11-14T00:00:00Z

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