Ataxin-3 deubiquitination is coupled to Parkin ubiquitination via E2 ubiquitin-conjugating enzyme. - Wikidata - wikimedia - TriplyDB

Ataxin-3 deubiquitination is coupled to Parkin ubiquitination via E2 ubiquitin-conjugating enzyme.

Ataxin-3 deubiquitination is coupled to Parkin ubiquitination via E2 ubiquitin-conjugating enzyme.

http://www.wikidata.org/entity/Q35643769

about

Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis Ataxin-3 is a multivalent ligand for the parkin Ubl domain Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection Ubiquitin modifications The business of deubiquitination - location, location, location RBR E3 ubiquitin ligases: new structures, new insights, new questions The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications Ataxia, dementia, and hypogonadotropism caused by disordered ubiquitination Trinucleotide repeats: a structural perspective Small, N-terminal tags activate Parkin E3 ubiquitin ligase activity by disrupting its autoinhibited conformation.USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin The emerging role of proteolysis in mitochondrial quality control and the etiology of Parkinson's disease.Opposing actions of heat shock protein 90 and 70 regulate nicotinamide adenine dinucleotide phosphate oxidase stability and reactive oxygen species production.Far-infrared radiation protects viability in a cell model of Spinocerebellar Ataxia by preventing polyQ protein accumulation and improving mitochondrial function The emerging role of deubiquitinating enzymes in genomic integrity, diseases, and therapeutics Regulation of Parkin E3 ubiquitin ligase activity.Posttranslational modification and quality control.Specificity and regulation of the endoplasmic reticulum-associated degradation machinery.Ataxin-3 and its e3 partners: implications for machado-joseph disease.Regulation of proteolysis by human deubiquitinating enzymes.Ataxin-3 protein and RNA toxicity in spinocerebellar ataxia type 3: current insights and emerging therapeutic strategies.From pathways to targets: understanding the mechanisms behind polyglutamine disease.DUBs, the regulation of cell identity and disease.Counteracting PINK/Parkin Deficiency in the Activation of Mitophagy: A Potential Therapeutic Intervention for Parkinson's Disease.Post translational modification of Parkin.Trumping neurodegeneration: Targeting common pathways regulated by autosomal recessive Parkinson's disease genes.Deubiquitylating enzymes and drug discovery: emerging opportunities.Impact of altered phosphorylation on loss of function of juvenile Parkinsonism-associated genetic variants of the E3 ligase parkin.

P2860

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P2860

Ataxin-3 deubiquitination is coupled to Parkin ubiquitination via E2 ubiquitin-conjugating enzyme.

http://www.wikidata.org/entity/Q35643769

description

2011 nî lūn-bûn

@nan

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

2011年论文

@zh

2011年论文

@zh-cn

name

Ataxin-3 deubiquitination is c ...... ubiquitin-conjugating enzyme.

@ast

Ataxin-3 deubiquitination is c ...... ubiquitin-conjugating enzyme.

@en

type

label

Ataxin-3 deubiquitination is c ...... ubiquitin-conjugating enzyme.

@ast

Ataxin-3 deubiquitination is c ...... ubiquitin-conjugating enzyme.

@en

prefLabel

Ataxin-3 deubiquitination is c ...... ubiquitin-conjugating enzyme.

@ast

Ataxin-3 deubiquitination is c ...... ubiquitin-conjugating enzyme.

@en

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P356

JBC.M111.288449

P1433

Journal of Biological Chemistry

P1476

Ataxin-3 deubiquitination is c ...... ubiquitin-conjugating enzyme.

@en

P2093

Maria Kontogiannea

http://www.w3.org/2001/XMLSchema#string

Nathalie Bedard

http://www.w3.org/2001/XMLSchema#string

Simon S Wing

http://www.w3.org/2001/XMLSchema#string

Thomas M Durcan

http://www.w3.org/2001/XMLSchema#string

P2860

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines

Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids

USP13 enzyme regulates Siah2 ligase stability and activity via noncatalytic ubiquitin-binding domains

Autoregulation of Parkin activity through its ubiquitin-like domain

The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

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531-541

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scholarly article

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10.1074/JBC.M111.288449

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1

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287

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2011-11-11T00:00:00Z

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22081612

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P921

protein ubiquitination

P932

3249107

http://www.w3.org/2001/XMLSchema#string